Vitamin D : A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994
1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Pho...
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| Autor*in: |
Norman, Anthony W [herausgeberIn] Thomasset, Monique [herausgeberIn] Bouillon, Roger [herausgeberIn] |
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| Format: |
E-Book |
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| Sprache: |
Englisch |
| Erschienen: |
Berlin Boston: De Gruyter ; 2020 |
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| Ausgabe: |
Reprint 2020 |
| Rechteinformationen: |
Restricted Access |
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| Schlagwörter: |
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| Umfang: |
1 Online-Ressource (966 p) |
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| Beschreibung: |
Mode of access: Internet via World Wide Web. |
| Reproduktion: |
[Online-Ausgabe] |
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| Links: | |
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| ISBN: |
978-3-11-088251-3 |
| DOI / URN: |
10.1515/9783110882513 |
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| Katalog-ID: |
1738075443 |
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| 245 | 1 | 0 | |a Vitamin D |b A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994 |c Anthony W. Norman, Monique Thomasset, Roger Bouillon |
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| 520 | |a 1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition -- | ||
| 520 | |a Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of | ||
| 533 | |a [Online-Ausgabe] | ||
| 538 | |a Mode of access: Internet via World Wide Web. | ||
| 546 | |a In English | ||
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| 700 | 1 | |a Thomasset, Monique |e herausgeberin |4 edt | |
| 700 | 1 | |a Bouillon, Roger |e herausgeberin |4 edt | |
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9783110882513 978-3-11-088251-3 10.1515/9783110882513 doi (DE-627)1738075443 (DE-599)KEP059273666 (DE-B1597)40064 (EBP)059273666 DE-627 eng DE-627 rda eng XA-DE SCI000000 bisacsh Vitamin D A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994 Anthony W. Norman, Monique Thomasset, Roger Bouillon Reprint 2020 Berlin Boston De Gruyter [2020] 1 Online-Ressource (966 p) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Restricted Access Controlled Vocabulary for Access Rights http://purl.org/coar/access_right/c_16ec 1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition -- Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of [Online-Ausgabe] Mode of access: Internet via World Wide Web. 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| spelling |
9783110882513 978-3-11-088251-3 10.1515/9783110882513 doi (DE-627)1738075443 (DE-599)KEP059273666 (DE-B1597)40064 (EBP)059273666 DE-627 eng DE-627 rda eng XA-DE SCI000000 bisacsh Vitamin D A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994 Anthony W. Norman, Monique Thomasset, Roger Bouillon Reprint 2020 Berlin Boston De Gruyter [2020] 1 Online-Ressource (966 p) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Restricted Access Controlled Vocabulary for Access Rights http://purl.org/coar/access_right/c_16ec 1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition -- Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of [Online-Ausgabe] Mode of access: Internet via World Wide Web. 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9783110882513 978-3-11-088251-3 10.1515/9783110882513 doi (DE-627)1738075443 (DE-599)KEP059273666 (DE-B1597)40064 (EBP)059273666 DE-627 eng DE-627 rda eng XA-DE SCI000000 bisacsh Vitamin D A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994 Anthony W. Norman, Monique Thomasset, Roger Bouillon Reprint 2020 Berlin Boston De Gruyter [2020] 1 Online-Ressource (966 p) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Restricted Access Controlled Vocabulary for Access Rights http://purl.org/coar/access_right/c_16ec 1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition -- Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of [Online-Ausgabe] Mode of access: Internet via World Wide Web. In English SCIENCE / General Norman, Anthony W herausgeberin edt Thomasset, Monique herausgeberin edt Bouillon, Roger herausgeberin edt 9783110141573 Erscheint auch als print 9783110141573 https://doi.org/10.1515/9783110882513 X:GRUY Resolving-System lizenzpflichtig https://www.degruyter.com/isbn/9783110882513 X:GRUY Verlag lizenzpflichtig https://www.degruyter.com/cover/covers/9783110882513.jpg X:GRUY Verlag Cover https://www.degruyter.com/document/cover/isbn/9783110882513/original X:GRUY Verlag Cover EBA-BACKALL EBA-DGALL EBA-EBACKALL EBA-EBKALL EBA-EEBKALL EBA-ESTMALL EBA-STMALL GBV-deGruyter-alles ZDB-23-GBA ZDB-23-GRW GBV_ILN_20 ISIL_DE-84 SYSFLAG_1 GBV_KXP GBV_ILN_21 ISIL_DE-46 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_34 ISIL_DE-18-302 GBV_ILN_60 ISIL_DE-705 GBV_ILN_65 ISIL_DE-3 GBV_ILN_69 ISIL_DE-9 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_120 ISIL_DE-715 GBV_ILN_122 ISIL_DE-897 GBV_ILN_130 ISIL_DE-700 GBV_ILN_140 ISIL_DE-839 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_264 ISIL_DE-897-1 GBV_ILN_285 ISIL_DE-517 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_736 GBV_ILN_2001 ISIL_DE-21 GBV_ILN_2006 ISIL_DE-14 GBV_ILN_2010 ISIL_DE-15 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2020 ISIL_DE-Ch1 GBV_ILN_2027 ISIL_DE-105 GBV_ILN_2044 ISIL_DE-751 GBV_ILN_2045 ISIL_DE-Mit1 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2063 ISIL_DE-951 GBV_ILN_2118 ISIL_DE-Mh35 BO 20 01 0084 4022324309 CATDESC_DGR-EB CATDESC_DGR-EB z 18-12-21 21 01 0046 4132257487 ebook_2023_degruyter_ebs Freie Nutzung im <a href="http://nbn-resolving.de/urn:nbn:de:gbv:46-campusnetz9" Target="_blank">Campusnetz</a> der Universitaet und der Hochschulen im Lande Bremen zza 11-05-22 22 01 0018 4110409969 00 --%%-- --%%-- s --%%-- SUBedegebs zu 02-04-22 23 01 0830 3809729698 olr-degruyter3 i z 20-11-20 24 01 0008 3805485425 00 --%%-- --%%-- s --%%-- olr-dgebs Vervielfältigungen (z.B. 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| allfieldsGer |
9783110882513 978-3-11-088251-3 10.1515/9783110882513 doi (DE-627)1738075443 (DE-599)KEP059273666 (DE-B1597)40064 (EBP)059273666 DE-627 eng DE-627 rda eng XA-DE SCI000000 bisacsh Vitamin D A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994 Anthony W. Norman, Monique Thomasset, Roger Bouillon Reprint 2020 Berlin Boston De Gruyter [2020] 1 Online-Ressource (966 p) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Restricted Access Controlled Vocabulary for Access Rights http://purl.org/coar/access_right/c_16ec 1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition -- Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of [Online-Ausgabe] Mode of access: Internet via World Wide Web. 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9783110882513 978-3-11-088251-3 10.1515/9783110882513 doi (DE-627)1738075443 (DE-599)KEP059273666 (DE-B1597)40064 (EBP)059273666 DE-627 eng DE-627 rda eng XA-DE SCI000000 bisacsh Vitamin D A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994 Anthony W. Norman, Monique Thomasset, Roger Bouillon Reprint 2020 Berlin Boston De Gruyter [2020] 1 Online-Ressource (966 p) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Restricted Access Controlled Vocabulary for Access Rights http://purl.org/coar/access_right/c_16ec 1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition -- Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of [Online-Ausgabe] Mode of access: Internet via World Wide Web. 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Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994</subfield><subfield code="c">Anthony W. Norman, Monique Thomasset, Roger Bouillon</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">Reprint 2020</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin</subfield><subfield code="a">Boston</subfield><subfield code="b">De Gruyter</subfield><subfield code="c">[2020]</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (966 p)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="506" ind1="1" ind2=" "><subfield code="a">Restricted Access</subfield><subfield code="e">Controlled Vocabulary for Access Rights</subfield><subfield code="u">http://purl.org/coar/access_right/c_16ec</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition --</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of</subfield></datafield><datafield tag="533" ind1=" " ind2=" "><subfield code="a">[Online-Ausgabe]</subfield></datafield><datafield tag="538" ind1=" " ind2=" "><subfield code="a">Mode of access: Internet via World Wide Web.</subfield></datafield><datafield tag="546" ind1=" " ind2=" 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Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="k">Zugriff auf den Volltext nur für Universitätsangehörige innerhalb des Netzes der Universität Kiel (Campuslizenz).</subfield><subfield code="y">z</subfield><subfield code="z">17-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">34</subfield><subfield code="1">01</subfield><subfield code="x">3551</subfield><subfield code="b">4080496672</subfield><subfield code="h">OLR-EBAKALL-EBS</subfield><subfield code="k">Zugriff nur im Netz der HAW Hamburg</subfield><subfield code="y">z</subfield><subfield code="z">05-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">60</subfield><subfield code="1">01</subfield><subfield code="x">0705</subfield><subfield code="b">4230810075</subfield><subfield code="h">DeGruyterArchiv</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots.</subfield><subfield code="k">Nur für Angehörige der HSU: Volltextzugang von außerhalb des Campus mit Anmeldung über Shibboleth mit Ihrer Bibliothekskennung</subfield><subfield code="y">z</subfield><subfield code="z">14-12-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">65</subfield><subfield code="1">01</subfield><subfield code="x">0003</subfield><subfield code="b">4420163887</subfield><subfield code="c">03</subfield><subfield code="f">--%%--</subfield><subfield code="d">ebook</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="h">DeGruyter-EBA</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">k3o</subfield><subfield code="z">14-12-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">69</subfield><subfield code="1">01</subfield><subfield code="x">0009</subfield><subfield code="b">390878073X</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="u">BF_dG</subfield><subfield code="y">z</subfield><subfield code="z">13-04-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">90</subfield><subfield code="1">01</subfield><subfield code="x">3090</subfield><subfield code="b">3809760366</subfield><subfield code="h">OLR-HILdegruyter</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">20-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">110</subfield><subfield code="1">01</subfield><subfield code="x">3110</subfield><subfield code="b">3809775118</subfield><subfield code="h">OLR-DEGRUYTER-EBS-2018</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="k">Volltextzugriff nur für berechtigte Personen über das Campusnetz</subfield><subfield code="y">z</subfield><subfield code="z">20-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">120</subfield><subfield code="1">01</subfield><subfield code="x">0715</subfield><subfield code="b">3814176685</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">g</subfield><subfield code="j">--%%--</subfield><subfield code="h">alma</subfield><subfield code="y">z</subfield><subfield code="z">27-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">122</subfield><subfield code="1">01</subfield><subfield code="x">0897</subfield><subfield code="b">3809658324</subfield><subfield code="h">OLR-deGruyter-EBS</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots</subfield><subfield code="y">z</subfield><subfield code="z">20-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">130</subfield><subfield code="1">01</subfield><subfield code="x">0700</subfield><subfield code="b">3986908110</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">s</subfield><subfield code="j">--%%--</subfield><subfield code="h">OLR-deGruyter-EBA-EBKALL</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">10-10-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">140</subfield><subfield code="1">01</subfield><subfield code="x">0839</subfield><subfield code="b">3809682829</subfield><subfield code="h">OLR-deGruyter-EBS</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots</subfield><subfield code="y">z</subfield><subfield code="z">20-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">147</subfield><subfield code="1">01</subfield><subfield code="x">3528</subfield><subfield code="b">3908937973</subfield><subfield code="h">OLR-EBS-DG</subfield><subfield code="k">Multiuser | freigeschaltet für Europa-Universität Flensburg, Hochschule Flensburg und Zentrale Hochschulbibliothek</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">13-04-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">264</subfield><subfield code="1">01</subfield><subfield code="x">3264</subfield><subfield code="b">3809698032</subfield><subfield code="h">OLR-deGruyter-EBS</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots</subfield><subfield code="y">z</subfield><subfield code="z">20-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">285</subfield><subfield code="1">01</subfield><subfield code="x">0517</subfield><subfield code="b">4590251078</subfield><subfield code="h">OLR-GRUY-TEST</subfield><subfield code="k">Zugriff zeitlich begrenzt (EBS)</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">10-10-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">370</subfield><subfield code="1">01</subfield><subfield code="x">4370</subfield><subfield code="b">408758545X</subfield><subfield code="h">EBS deGruyter</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. 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--%%-- |
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| format |
eBook |
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keep |
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KXP GVK SWB |
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Berlin Boston |
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true |
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vitamin da pluripotent steroid hormone: structural studies, molecular endocrinology and clinical applications. proceedings of the ninth workshop on vitamin d, orlando, florida, usa, may 28–june 2, 1994 |
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Vitamin D A Pluripotent Steroid Hormone: Structural Studies, Molecular Endocrinology and Clinical Applications. Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994 |
| abstract |
1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition -- Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of |
| abstractGer |
1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition -- Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of |
| abstract_unstemmed |
1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition -- Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- Receptor Mediated Genomic Actions of 1,25(OH)2D3: Modulation by Phosphorylation -- Modulation of Vitamin D3 Target Gene Selectivity by Receptor Dimerization -- The Molecular Basis for the Genomic Actions of the Vitamin D3 Hormone -- Expression of RXRa in Human Leukemic Cells During Differentiation Induced by All-Trans Retinoic Acid and 1a,25-Dihydroxyvitamin D -- Differential Activation of the Vitamin D Receptor (VDR) by 1,25(OH)2- Vitamin D3 and its 20-Epimers -- Dopamine Activates Vitamin D Receptor But Not Retinoid Receptor Mediated Transcription -- Ordered Binding of Human Vitamin D and Retinoid-X Receptor Complexes to Asymmetric Vitamin D-Responsive Elements -- Immunohistochemical Localization of |
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Vitamin D |
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Proceedings of the Ninth Workshop on Vitamin D, Orlando, Florida, USA, May 28–June 2, 1994</subfield><subfield code="c">Anthony W. Norman, Monique Thomasset, Roger Bouillon</subfield></datafield><datafield tag="250" ind1=" " ind2=" "><subfield code="a">Reprint 2020</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">Berlin</subfield><subfield code="a">Boston</subfield><subfield code="b">De Gruyter</subfield><subfield code="c">[2020]</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (966 p)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="506" ind1="1" ind2=" "><subfield code="a">Restricted Access</subfield><subfield code="e">Controlled Vocabulary for Access Rights</subfield><subfield code="u">http://purl.org/coar/access_right/c_16ec</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">1,25-Dihydroxy vitamin D3 [1,25(OH)2D3] Receptors (VDR) in Human and Rat Pancreas -- Structure-Function Relationship of Human Parathyroid Hormone on Vitamin D Receptor Regulation in Osteoblast-Like Cells (ROS 17/2.8) -- Insulin-Like Growth Factor I Up-Regulates Intestinal 1,25(OH)2D3 Receptor in Phosphorus Restricted Rats -- A Peptide C-Terminal to the Second Zn-Finger of Human Vitamin D Receptor is Able to Specify Nuclear Localization -- Molecular Cloning and Sequencing of a Novel cDNA Related to the Steroid/Thyroid/Vitamin Family of Nuclear Receptors from a Vitamin DDeficient Chick Intestinal cDNA Library -- Isolation and Analysis of cDNA Encoding a Naturally-Occurring Truncated Form of the Human Vitamin D Receptor -- EB 1089, a Vitamin D Analogue, Induces the Vitamin D Receptor to Form Selective Receptor Complexes Depending on Cell Type -- Gene Regulation -- 1,25(OH)2D3 Response Elements: Is There an Order? -- Vitamin D Regulation of Osteocalcin Gene Transcription: A Model for Defining Molecular Mechanisms of 1,25(OH)2D3 Control of Osteoblast Growth and Differentiation -- Regulation of Integrin Expression by 1,25 Dihydroxyvitamin D3 -- Identification of a Chicken Intestinal DNA Binding Activity Not Related to the Vitamin D Receptor, but Capable of Specific Binding to Vitamin D Response Elements -- Transcriptional Regulation of the Avian Mitochondrial Genome by Altered Dietary Vitamin D3 Status: A Comparison of Intestinal and Kidney Responses -- A Novel Vitamin D Response Element in the Murine c-fos Promoter -- 1,25(OH)2-Vitamin D3 (D3) Interactions with 3,5,3'-Triiodothyronine (T3) Signaling in 3 Osteosarcoma Cell Lines -- 1,25(OH)2-Vitamin D3 (D3) Signaling in HT-29 Cells: Interactions with 9-eis Retinoic Acid (9-eis RA) -- Protein Inhibitor of Cyclic AMP-Dependent Protein Kinase: Genomic Cloning of a 1,25(OH)2D3 Down-Regulated Protein -- Lack of 9-eis Retinoic Acid Effect on Renal 24-Hydroxylase mRNA Expression by 1,25-Dihydroxyvitamin D3 In Vivo -- Regulation of Osteopontin Expression by Calcitriol in Mouse Epidermal JB6 Cells -- Dissociation between Regulation of Growth and C-myc Oncogen Expression by Vitamin D in Caco-2 Cells -- TGF-ßl Inhibits the Induction of Osteocalcin Gene by 1,25(OH)2D3 at the Level of Transcription -- Mechanism of Action of 1,25-Dihydroxyvitamin D Differs in Kidney, Intestine, and Bone Cell Lines -- mRNA Levels of the Inhibitor Protein of cAMP-Dependent Protein Kinase are Regulated by 1,25(OH)2D3 and Forskolin -- Vitamin D Receptor (VDR) Interactions with Vitamin D3 Response Elements (VDRE) in the Parathyroid Hormone (PTH) and Osteocalcin Genes are Different -- Coordinate Regulation of Rat Parathyroid Gland Function by Calcium and 1,25- Dihydroxyvitamin D3 -- Phosphorylation Pathways Affect Binding of AP-1 and Vitamin D Receptor to their Combined Response Element in the Promoter Region of Human Osteocalcin Gene -- Rapid Actions of Vitamin D Steroids -- Transmembrane Signal Pathways Induced by Calcitriol, Estradiol, Testosterone and Progesterone in Osteoblasts -- Non-Nuclear Actions of 1a,25(OH)2D3 and 24R,25(OH)2D3 in Mediating Intestinal Calcium Transport: The Use of Analogs to Study Membrane Receptors for Vitamin D Metabolites and to Determine Receptor Ligand Conformational Preferences -- Nongenomic Effects of Vitamin D -- Binding of the Occupied Vitamin D Receptor (VDR) to Extra-Nuclear Sites: A Potential Mechanism of Nongenomic Actions of 1a,25(OH)2D3 -- A Common Mechanism for the Vitamin D Reeeptor Activation and for the Nongenomic Actions of Calcitriol -- The Calciotropic Hormone 1,25(OH)2-Vitamin D3 Stimulates Phospholipase D Activity in Cultured Muscle Cells -- Rapid Non-Genomic Effect of 1a,25-Dihydroxyvitamin D3 on Osteoblast Nuclei -- 1a,25-Dìhydroxyvitamin D3 Induces a Rapid and Sustained Increase in Cytosolic Calcium in Cultured Human Keratinocytes -- Aged-Related Changes in the Non-Genomic Response of Intestinal Mammalian Cells to 1,25-Dihydroxy-Vitamin D3 -- Video Imaging of Intracellular Calcium in Insulinoma Cells: Effects of 1,25(OH)2D3 -- Cellular Signalling Responses Mediated by 1,25(OH)2-Vitamin D3 in Rat and Chick Myoblasts -- Involvement of Adenylate Cyclase System in 1,25-Dihydroxyvitamin D3 Rapid Stimulation of Ca2 + Uptake by Heart Cells -- Specific Binding of 1,25-Dihydroxyvitamin D3 to Rat Colonocyte Basolateral Membranes -- Protein Kinase C Participates in the Signal Transduction Pathway Triggered by 1,25-Dihydroxyvitamin D3 in Myocytes -- Calbindins D—Function and Gene Regulation: Calcium Transport -- Mechanistic Studies on Intestinal Ca2 + Transport -- Vitamin D, the Intestinal Plasma Membrane Calcium Pump Gene Expression and the Calbindins -- Tissue Specific Calbindin-D9K Gene Regulation by Calcitriol and Sexual Hormones -- Proteins that Bind to the Calbindin-D9K Promoter: Known Factors and a New Intestinal Factor -- Studies of the Human Calbindin-D9K Gene -- Calbindins Revisited in the Rat Dental Pulp -- In Situ Hybridization of Calbindins mRNAs in Rat Ameloblasts -- Immunoreactive Calbindins-D28K and 9K Mineralization of Rat Epiphyseal Chondrocytes in Culture -- Regulation of Calbindin-D28K by Parathyroid Hormone in MDBK Cells -- Phosphorylation and Modulation of Calbindin D28K by Activation of Protein Kinase C (PKC) -- Caco-2 Cells: A Human Intestinal Cell Line for Studying the Biologic Activity of Vitamin D Analogs -- EGF Down Regulates Both Calbindin D28K and the VDR in MDBK Cells -- Does Calbindin-D28K Buffer Intracellular Free Calcium? -- Calbindin-D28K (CaBP-D28K) in the Rat Endocrine Pancreas: In Vivo and In Vitro Immunolocalization and its Regulation by Vitamin D3 Deficiency and 1,25- Dihydroxyvitamin D3 -- Effect of Two Antiestrogens (Tamoxifen and ICI 182780) on Calbindin-D9K Gene Expression In Vivo in the Rat Uterus, and In Vitro in Primary Cultures of Myometrial Cells -- Identification of a 9 kDa Calcium-Binding Protein in the Chick as Calbindin-D9K -- Effect of Antisense Sequences Against Calretinin on WiDr Cells -- Intestinal Absorption of Calcium and Strontium Demonstrate a Similar Response to Calcitriol Treatment -- Physiological Concentrations of 24,25(OH)2 Vitamin D3 Decrease the Intestinal Calcium Uptake in the Atlantic Cod, Gadus Morhua -- Effects of Vitamin D and DL-Buthionine-S, R-Sulfoximine on Intestinal Calcium Absorption -- 1,25-(OH)2D3 Stimulates Ca2+ -Uptake Across the Duodenal Brush Border by at Least Two Independent Mechanisms -- Effect of Heavy Metals on the Level of Calbindin D28K and the Assimilation of Ca in Chick Duodenum -- Apparent Nephron Localization of the 1,25(OH)2D3-Stimulated Calmodulin Binding Proteins in the Rat Kidney -- Raised Intestinal Calcium Secretion in the Young Oophorectomised Rat -- Validation of a Simple Test Measuring Intestinal Calcium Absorption Using Strontium as a Marker -- Cell Differentiation -- In Vitro Effects of Potent Vitamin D3 Analogs on Proliferation and Differentiation of Seven Human Breast Cancer Cell Lines -- Terminal Differentiation of Human Leukemia Cells (HL60) by a Combination of 1,25-Dihydroxyvitamin D3 and Retinoic Acid (All Trans or 9-Cis) -- 1,25-Dihydroxyvitamin D3 Induces Growth of Thyroid C Cells and Inhibits Calcitonin Secretion In Vitro -- Differentiation of Human Myelomonocytic Leukemia Cell Lines by Retinoic Acid and Vitamin D3 Analogs, MC903 and EB1089: Characterization of Cooperative Effects -- Effect of Ascorbate and Calcitriol on HL-60 Promyelocytic Cell Line Proliferation and Differentiation -- Evidence for a Vitamin D Paracrine System Regulating Fetal Pneumocyte Type II Maturation: Local Synthesis of 1,25-(OH)2D3 by Lung Fibroblasts -- Inhibition of IEC-6 Cell Growth by 1,25(OH)2D3: Involvement of TGFß -- Interactions between Vitamin D Derivatives, Retinoids and Granulocyte Macrophage - Colony Stimulating Factor in Leukemic Cell Differentiation -- 1,25(OH)2D3 and Agents that Increase Intracellular cAMP Synergistically Inhibit the Proliferation of Mouse Fibroblasts -- 1a,25-Dihydroxyvitamin D Rapidly Triggers Inhibition of Fibroblast Contraction of Collagen Lattices -- Cancer -- Immunology -- Dermatology -- Neurosciences -- Renal Osteodystrophy -- Bone and Cartilage -- Miscellaneous Biological Actions of Vitamin D Metabolites and Analogs -- Assays for Vitamin D Steroids -- Nutrition --</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Vitamin D -- Frontmatter -- FOREWORD -- Official Sponsors and Donors -- YOUNG INVESTIGATOR AWARDEES NINTH WORKSHOP ON VITAMIN D -- Vitamin D Workshop. Career Recognition Awardees -- Contents -- Chemistry of Vitamin D -- Shape and Conformation of Vitamin D. 11-Fluoro-1a-Hydroxyvitamin D3: The Quest for Experimental Evidence of the Folded Vitamin D Conformation -- Conformation and Related Topological Features of Vitamin D: Structure-Function Relationships -- Chemical Conversion of Vitamin D3 to Calcitriol Lactone -- Design, Synthesis, and SAR of Some 1-Substituted A-Ring Analogs of Calcitriol -- A General Synthetic Route to A-Ring Hydroxylated Vitamin D Analogs from D-Pentoses -- Retiferols. Design and Synthesis of the New Class of Vitamin D Analogs -- Introduction of 1a-Hydroxyl Group to Provitamin D Causes New Photoisomerization Reactions -- Synthesis and Determination of the Configurations of the 23-Hydroxylated Metabolites of Calcipotriol (MC 903) and their Epimers -- Syntheses of Potential Inhibitors of 25-Hydroxyvitamin D3-1a-Hydroxylase: A-Ring Analogs -- Metallic Complexes of Hydroxylated Derivatives of Vitamin D3 -- A New Route to the Lythgoe-Roche's A-Ring Precursor of 1a,25-Dihydroxyvitamin D3 -- Structure-Activity Studies of Fluorinated Vitamin D Analogs -- An In Vitro Model of Previtamin D Photosynthesis as Possible Monitor of Ozone Depletion -- Synthesis of 24-Hydroxy-Vitamin D Analogues -- Chromatographic Isolation and Spectroscopic Characterization of the Photoisomers of 1a,25-Dihydroxy-Provitamin D3 -- A New Route to the Vitamin D Triene System -- Studies on the Synthesis of 19-Norprevitamin D3 Analogues -- Structure/Function Studies of Vitamin D Steroids -- The Need for New Vitamin D Analogues: Mechanisms of Action and Clinical Applications -- Future Prospects for Vitamin D Analogs -- Chemistry and Biology of 22,23-yne Analogs of Calcitriol -- Chemistry and Biology of 23-oxa-aro- and 23-thia-aro-Vitamin D Analogues with High Antiproliferative and Low Calcemic Activity -- Activity of Vitamin D Analogs in Co-Transfected COS-7 Cells -- Synthesis and Biological Character of 1β-Hydroxylated Vitamin D3 Analogs -- Biological Activity and Conformational Analysis of 1β,25-Dihydroxyvitamin D3 and its Analogues -- Topological Mimics of the 6-s-cis-Conformer of 1a,25-Dihydroxyvitamin D3 Based on the Provitamin D Skeleton -- Chemistry and Biology of Highly Active 22-oxy Analogs of 20-epi Calcitriol with Very Low Binding Affinity to the Vitamin D Recepto -- New Discoveries in Vitamin D Related Compounds -- Modelling of Previtamin D Photosynthesis in View of its Conformational Flexibility -- Active Vitamin D Analogs with Side Chain Hydroxyl Group Occupying Diverse Spatial Region -- Synthesis and Biological Activity of 23-oxa Vitamin D Analogues -- Synthesis and Biological Activity of 20-Hydroxylated Vitamin D Analogues -- 20-Methyl Vitamin D Analogues -- 2β-Substituted Calcitriols and Other A-Ring Substituted Analogues - Synthesis and Biological Results -- Syntheses and Biological Activity of 1ß-Substituted Active Vitamin D3 Analogs -- Vitamin D Binding Protein -- Probing the Vitamin D-Sterol Binding Domain of Human Vitamin D-Binding Protein: Chemical Modification of Specific Amino Acid Residues -- Crystallization and Preliminary X-Ray Investigation of Vitamin D-Binding Protein from Human Serum -- Effects of Vitamin D-Binding Proteins on Biological Functions of 1 a,25-Dihydroxyvitamin D3 Analogues -- Vitamin D Hydroxylases: Biochemistry and Regulation -- Differences of the Regulation of 24-Hydroxylase Gene Expression in the Kidney and Intestine -- Regulation of the Ferredoxin Component of Renal Hydroxylases at the Transcriptional and Postradiational Level and of the Protein Inhibitor of Cyclic AMP-Dependent Kinase -- Site and Rate of Hydroxylation of 1a-OH-D3 Analogs by CYP27 Not Altered by Increasing Length or Changing Orientation of Vitamin D3 Side Chain -- Protein Kinase C Up-Regulates 1 a,25-Dihydroxyvitamin D3-Induced Expression of 24-Hydroxylase Gene -- IGF-I Restores the Age-Related Defect in Renal 1,25(OH)2D3 Biosynthesis in Response to Dietary Phosphorus Restriction in Rats -- In Vitro Production of 1,25-Dihydroxyvitamin D3 by Cultured Mouse Kidney Cells and its Regulation by Extracellular Phosphate and IGF-1 -- The Cytochromes P450 Catalyzing 25-Hydroxylation of Vitamin D and la-Hydroxy lation of 25-Hydroxyvitamin D3 in Pig Liver -- Evidence that 1a - and 27-Hydroxylation of 25-Hydroxyvitamin D3 are Catalyzed by CYP27 in Pig Kidney Mitochondria -- The Kinetics of Monocyte la-Hydroxy läse in Uremia. Modulation by Calcitriol and 25(OH)D3 Therapy -- Eicosanoid Inhibitor and Cytokine Regulation of 1,25(OH)2D3 Synthesis in Synovial Fluid Macrophages from Patients with Inflammatory Arthritis -- 25-Hydroxyvitamin D-la-Hydroxy läse is Responsible for the Synthesis of 1.25-Dihydroxyvitamin D3 by Peritoneal Macrophages of CAPD Treated Uremic Patients -- Influence of Extracellular Calcium in the Kinetic Behaviour of 1-Hydroxylase (1-OHase) and 24-Hydroxylase (24-OHase) in Walker Carcinosarcoma 256 Cells (WS) and in the Renal Proximal Tube Phenotype Cells (LLC-PK1) -- Insulin and Calcitonin Decrease the Expression of the Renal 25(OH)D-24- Hydroxylase Cytochrome P450 in Diabetic Rats -- Continuous Activation of 25-Hydroxyvitamin D3-24-Hydroxylase mRNA Expression by 1a,25-Dihydroxyvitamin D3-3ß-Bromoacetate -- Regulation of 24-Hydroxylase mRNA Expression by 1a,25(OH)2D3 and its Fluorinated Analogues -- Comparative Effects of 1,25-Dihydroxyvitamin D3 and EB 1089 on Murine 25-Hydroxyvitamin D3-24-Hydroxylase -- Vitamin D Metabolism and Catabolism -- Target Cell Metabolism of Vitamin D and its Analogs -- In Vivo Regulation of Rat Intestinal 24-Hydroxylase (I-24-OHase): Potential New Role of Calcitonin -- Metabolism of 1a,25-Dihydroxyvitamin D3 and One of its A-Ring Diastereomer 1a,25-Dihydroxy-3-Epivitamin D3 in Neonatal Human Keratinocytes -- Vitamin D Metabolism in Human Colon Adenocarcinoma-Derived Caco-2 Cells -- Studies on Vitamin D Metabolism by a Human Small Cell Lung Cancer (SCLC) Cell Line, NCI-H82 -- The In Vitro Metabolism of Calcipotriol, 1,24(OH)2D3 and 1,25(OH)2D3 -- Regulation of Tissue Inhibitor of Metalloproteinases (TIMP) by 1,25- and 24,25- Dihydroxyvitamin D3 in the Rat Growth Plate -- The Effect of Parathyroid Hormone on Renal 24-Hydroxylase Activity in the Isolated Perfused Rat Kidney -- Steroidal Hormones as Modulators of Vitamin D Metabolism in Human Keratinocytes -- Potentialisation of Vitamin D (Analogs) by Cytochrome P-450 Enzyme Inhibitors is Analog- and Cell-type Specific -- Novel Cleavage of Vitamin D2 Side Chain During Catabolism by Keratinocyte Cell Line -- 22-Oxacalcitriol is Metabolized to C21 Side-Chain-Cleaved Products in Both Liver and Target Cells -- Metabolism of the 1a,25(OH)2D3 Analog 1a,25(OH)2-16-ene-23-yne-D3 in BALB/c Leukemic Mice and WEHI-3 Myeloid Leukemia Cells -- Microtubules Mediate Cellular 25(OH)D3 Traffic and the Response to 1,25(OH)2D3 in Human Monocytes -- Study of the Metabolism of 1,25-Dihydroxy-16-ene-Vitamin D3 in Rat Kidney Using On-line HPLC-Electrospray Tandem Mass Spectrometry -- Human Placental Explants: An Efficient In Vitro Model for Comparative Metabolism of 1,25(OH)2D3 and its Synthetic Analogs -- 24,25(OH)2D3 Modulates 1,25(OH)2D3 Metabolism in Human Osteoblasts -- Metabolism of 25 Hydroxy Vitamin D3: Kinetics of 23 and 24 Hydroxylases in Human Term Placenta -- Comparative Study in Vitamin D Metabolism from the View-Point of Ontogeny and Phylogeny -- Receptors for 1a,25(OH)2D3 -- 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Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="k">Volltextzugriff nur für berechtigte Personen über das Campusnetz</subfield><subfield code="y">z</subfield><subfield code="z">20-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">120</subfield><subfield code="1">01</subfield><subfield code="x">0715</subfield><subfield code="b">3814176685</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">g</subfield><subfield code="j">--%%--</subfield><subfield code="h">alma</subfield><subfield code="y">z</subfield><subfield code="z">27-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">122</subfield><subfield code="1">01</subfield><subfield code="x">0897</subfield><subfield code="b">3809658324</subfield><subfield code="h">OLR-deGruyter-EBS</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots</subfield><subfield code="y">z</subfield><subfield code="z">20-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">130</subfield><subfield code="1">01</subfield><subfield code="x">0700</subfield><subfield code="b">3986908110</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">s</subfield><subfield code="j">--%%--</subfield><subfield code="h">OLR-deGruyter-EBA-EBKALL</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">10-10-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">140</subfield><subfield code="1">01</subfield><subfield code="x">0839</subfield><subfield code="b">3809682829</subfield><subfield code="h">OLR-deGruyter-EBS</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots</subfield><subfield code="y">z</subfield><subfield code="z">20-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">147</subfield><subfield code="1">01</subfield><subfield code="x">3528</subfield><subfield code="b">3908937973</subfield><subfield code="h">OLR-EBS-DG</subfield><subfield code="k">Multiuser | freigeschaltet für Europa-Universität Flensburg, Hochschule Flensburg und Zentrale Hochschulbibliothek</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">13-04-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">264</subfield><subfield code="1">01</subfield><subfield code="x">3264</subfield><subfield code="b">3809698032</subfield><subfield code="h">OLR-deGruyter-EBS</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots</subfield><subfield code="y">z</subfield><subfield code="z">20-11-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">285</subfield><subfield code="1">01</subfield><subfield code="x">0517</subfield><subfield code="b">4590251078</subfield><subfield code="h">OLR-GRUY-TEST</subfield><subfield code="k">Zugriff zeitlich begrenzt (EBS)</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">10-10-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">370</subfield><subfield code="1">01</subfield><subfield code="x">4370</subfield><subfield code="b">408758545X</subfield><subfield code="h">EBS deGruyter</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots.</subfield><subfield code="u">i</subfield><subfield code="y">z</subfield><subfield code="z">10-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">736</subfield><subfield code="1">01</subfield><subfield code="x">4736</subfield><subfield code="b">4493805706</subfield><subfield code="h">DeGryuterEBS2024</subfield><subfield code="u">verv</subfield><subfield code="y">zeg</subfield><subfield code="z">29-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2001</subfield><subfield code="1">01</subfield><subfield code="x">DE-21</subfield><subfield code="b">3937077448</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">kp</subfield><subfield code="y">l01</subfield><subfield code="z">11-06-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2006</subfield><subfield code="1">01</subfield><subfield code="x">DE-14</subfield><subfield code="b">4427458475</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">06-12-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2010</subfield><subfield code="1">01</subfield><subfield code="x">DE-15</subfield><subfield code="b">4427252753</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - Campuslizenz</subfield><subfield code="y">l01</subfield><subfield code="z">06-12-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2018</subfield><subfield code="1">01</subfield><subfield code="x">DE-31</subfield><subfield code="b">4244649409</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">n</subfield><subfield code="j">n</subfield><subfield code="k">Für registrierte BenutzerInnen ist der Zugriff auch außerhalb der BLB möglich.</subfield><subfield code="y">l01</subfield><subfield code="z">05-01-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2020</subfield><subfield code="1">01</subfield><subfield code="x">DE-Ch1</subfield><subfield code="b">443906647X</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Campuslizenz</subfield><subfield code="y">l01</subfield><subfield code="z">16-12-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2027</subfield><subfield code="1">01</subfield><subfield code="x">DE-105</subfield><subfield code="b">4460626888</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Campuslizenz</subfield><subfield code="y">l01</subfield><subfield code="z">17-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2044</subfield><subfield code="1">01</subfield><subfield code="x">DE-751</subfield><subfield code="b">4586897546</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook de Gruyter</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Campuslizenz bis 30.09.2025. Bitte beachten Sie die Nutzungshinweise auf unserer Homepage (de Gruyter)</subfield><subfield code="y">l01</subfield><subfield code="z">03-10-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2045</subfield><subfield code="1">01</subfield><subfield code="x">DE-Mit1</subfield><subfield code="b">4490355238</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Volltext - Campuslizenz</subfield><subfield code="y">l01</subfield><subfield code="z">22-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2050</subfield><subfield code="1">01</subfield><subfield code="x">DE-Zi4</subfield><subfield code="b">4439066488</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Zugriff im HSZG-Campusnetz. Zugriff von auβerhalb nur für HSZG-Angehörige.</subfield><subfield code="y">l01</subfield><subfield code="z">16-12-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2063</subfield><subfield code="1">01</subfield><subfield code="x">DE-951</subfield><subfield code="b">3822572322</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook de Gruyter</subfield><subfield code="e">n</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - Campuslizenz</subfield><subfield code="y">l01</subfield><subfield code="z">10-12-20</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2118</subfield><subfield code="1">01</subfield><subfield code="x">DE-Mh35</subfield><subfield code="b">444286263X</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook de Gruyter</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - 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7.1677475 |