Molecular Dynamics at the Immunological Synapse
The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T ly...
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| Autor*in: |
Pedro Roda-Navarro [verfasserIn] Andres Alcover [verfasserIn] Vincenzo Di Bartolo [verfasserIn] |
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| Format: |
E-Book |
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| Sprache: |
Englisch |
| Erschienen: |
Erscheinungsort nicht ermittelbar: Frontiers Media SA ; 2017 |
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| Rechteinformationen: |
Open Access Creative Commons ; https://creativecommons.org/licenses/by/4.0 |
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| Umfang: |
1 Online-Ressource (120 p.) |
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| Reihe: |
Frontiers Research Topics |
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| Links: | |
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| ISBN: |
978-2-88945-133-3 |
| Katalog-ID: |
1778565255 |
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| 520 | |a The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies | ||
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9782889451333 978-2-88945-133-3 20.500.12854/53834 hdl (DE-627)1778565255 (DE-599)KEP069632316 (OCoLC)1002254070 (DOAB)53834 (EBP)069632316 DE-627 ger DE-627 rakwb eng Pedro Roda-Navarro verfasserin aut Molecular Dynamics at the Immunological Synapse [Erscheinungsort nicht ermittelbar] Frontiers Media SA 2017 1 Online-Ressource (120 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Frontiers Research Topics Open Access Unrestricted online access star The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies Creative Commons https://creativecommons.org/licenses/by/4.0 cc English Andres Alcover verfasserin aut Vincenzo Di Bartolo verfasserin aut https://directory.doabooks.org/handle/20.500.12854/53834 X:DOAB Verlag kostenfrei ZDB-94-OAB GBV_ILN_11 ISIL_DE-1a SYSFLAG_1 GBV_KXP GBV_ILN_20 ISIL_DE-84 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_60 ISIL_DE-705 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_91 ISIL_DE-HIL3 GBV_ILN_92 ISIL_DE-33 GBV_ILN_95 ISIL_DE-542 GBV_ILN_105 ISIL_DE-841 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_120 ISIL_DE-715 GBV_ILN_130 ISIL_DE-700 GBV_ILN_131 ISIL_DE-Va1 GBV_ILN_132 ISIL_DE-959 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_285 ISIL_DE-517 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_635 ISIL_DE-B2138 GBV_ILN_808 GBV_ILN_2011 ISIL_DE-16 GBV_ILN_2014 ISIL_DE-90 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2034 ISIL_DE-Rt2 GBV_ILN_2037 ISIL_DE-747 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2108 ISIL_DE-991 GBV_ILN_2403 ISIL_DE-LFER BO 11 01 0001 4023417858 00 5:LIZFREI --%%-- --%%-- --%%-- k 21-12-21 20 01 0084 4012090933 OLR-DOAB z 02-12-21 22 01 0018 4006182341 OLR-ZDB-94-OAB DOAB Directory of Open Access Books zu 25-11-21 23 01 0830 4006700245 olr-doab f z 25-11-21 24 01 0008 4060182915 OLR-doab z 15-02-22 30 01 0104 4102264787 OLR-OAB Open Access, Directory of Open Access Books (DOAB) z 26-03-22 31 01 0027 4052520319 OLR-DOAB z 07-02-22 39 01 0547 4106001322 OLR-ZDB-94-OAB ke 29-03-22 40 01 0007 4011655589 OLR-DOAB xsn 01-12-21 60 01 0705 4276008328 OPENAccess Vervielfältigungen (z.B. 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9782889451333 978-2-88945-133-3 20.500.12854/53834 hdl (DE-627)1778565255 (DE-599)KEP069632316 (OCoLC)1002254070 (DOAB)53834 (EBP)069632316 DE-627 ger DE-627 rakwb eng Pedro Roda-Navarro verfasserin aut Molecular Dynamics at the Immunological Synapse [Erscheinungsort nicht ermittelbar] Frontiers Media SA 2017 1 Online-Ressource (120 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Frontiers Research Topics Open Access Unrestricted online access star The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies Creative Commons https://creativecommons.org/licenses/by/4.0 cc English Andres Alcover verfasserin aut Vincenzo Di Bartolo verfasserin aut https://directory.doabooks.org/handle/20.500.12854/53834 X:DOAB Verlag kostenfrei ZDB-94-OAB GBV_ILN_11 ISIL_DE-1a SYSFLAG_1 GBV_KXP GBV_ILN_20 ISIL_DE-84 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_60 ISIL_DE-705 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_91 ISIL_DE-HIL3 GBV_ILN_92 ISIL_DE-33 GBV_ILN_95 ISIL_DE-542 GBV_ILN_105 ISIL_DE-841 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_120 ISIL_DE-715 GBV_ILN_130 ISIL_DE-700 GBV_ILN_131 ISIL_DE-Va1 GBV_ILN_132 ISIL_DE-959 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_285 ISIL_DE-517 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_635 ISIL_DE-B2138 GBV_ILN_808 GBV_ILN_2011 ISIL_DE-16 GBV_ILN_2014 ISIL_DE-90 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2034 ISIL_DE-Rt2 GBV_ILN_2037 ISIL_DE-747 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2108 ISIL_DE-991 GBV_ILN_2403 ISIL_DE-LFER BO 11 01 0001 4023417858 00 5:LIZFREI --%%-- --%%-- --%%-- k 21-12-21 20 01 0084 4012090933 OLR-DOAB z 02-12-21 22 01 0018 4006182341 OLR-ZDB-94-OAB DOAB Directory of Open Access Books zu 25-11-21 23 01 0830 4006700245 olr-doab f z 25-11-21 24 01 0008 4060182915 OLR-doab z 15-02-22 30 01 0104 4102264787 OLR-OAB Open Access, Directory of Open Access Books (DOAB) z 26-03-22 31 01 0027 4052520319 OLR-DOAB z 07-02-22 39 01 0547 4106001322 OLR-ZDB-94-OAB ke 29-03-22 40 01 0007 4011655589 OLR-DOAB xsn 01-12-21 60 01 0705 4276008328 OPENAccess Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots. Nur für Angehörige der HSU: Volltextzugang von außerhalb des Campus mit Anmeldung über Shibboleth mit Ihrer Bibliothekskennung z 24-02-23 63 01 3401 4106635798 E-Books LF GBV-DOAB z 30-03-22 65 01 0003 4109332532 OLR-DOAB Nach dem deutschen Urheberrecht darf das Werk bzw. der Inhalt zum eigenen Gebrauch kostenfrei heruntergeladen, konsumiert, gespeichert oder ausgedruckt, nicht jedoch im Internet bereitgestellt oder an Außenstehende weitergegeben werden! z 01-04-22 70 01 0089 4006438931 OLR-DOAB-OA DOAB Directory of Open Access Books z 25-11-21 72 01 0035 4104687782 OLR-ZDB-94-OAB DOAB Directory of Open Access Books z 28-03-22 90 01 3090 4106427532 OLR-HILoapen z 29-03-22 91 01 3091 4011407429 OLR-DOAB DOAB Directory of Open Access Books z 01-12-21 92 01 0033 4110784026 OLR-Open Access DOAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. Das Ebook ist frei zugänglich. z 02-04-22 95 01 3095 4342276267 OLR-OAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 23-06-23 105 01 0841 4007161275 OLR-OAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 25-11-21 110 01 3110 4019861064 OLR-DOAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. 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Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 27-04-22 161 01 0960 4150965951 OLR-DOAB DOAB Directory of Open Access Books z 16-06-22 213 01 0551 4108644743 OLR-DOAB DOAB Directory of Open Access Books z 31-03-22 230 01 0552 4123543278 OLR-DOAB DOAB Directory of Open Access Books z 27-04-22 283 01 3283 4157121872 Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 28-06-22 285 01 0517 4050349736 OLR-DOAB z 03-02-22 293 01 3293 4153762806 OLR-DOAB DOAB Directory of Open Access Books z 21-06-22 370 01 4370 4125616906 OLR-FREE Kostenloser Zugriff z 28-04-22 635 01 3635 4509926065 OLR-DOAB Open Access. Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 11-04-24 808 01 4808 4158159938 OLR-DOAB DOAB Directory of Open Access Books zg 29-06-22 2011 01 DE-16 4022767960 00 --%%-- --%%-- --%%-- --%%-- l01 20-12-21 2014 01 DE-90 4010971215 00 --%%-- --%%-- --%%-- --%%-- l01 01-12-21 2018 01 DE-31 4033330488 00 --%%-- --%%-- --%%-- n Der Zugriff ist kostenfrei möglich. l01 11-01-22 2034 01 DE-Rt2 4013972336 00 --%%-- eBook n n frei zugänglich l01 04-12-21 2037 01 DE-747 4346269656 00 --%%-- eBook OAPEN Foundation OpenAccess --%%-- n Im Internet frei verfügbar l01 01-07-23 2050 01 DE-Zi4 4091499953 00 --%%-- --%%-- --%%-- n Elektronischer Volltext - Open Access l01 16-03-22 2108 01 DE-991 4096651672 00 --%%-- eBook DOAB --%%-- n Elektronischer Volltext - Campuslizenz l01 19-03-22 2403 01 DE-LFER 4019060975 00 --%%-- --%%-- n --%%-- l01 11-12-21 20 01 0084 https://directory.doabooks.org/handle/20.500.12854/53834 22 01 0018 Volltextzugang https://directory.doabooks.org/handle/20.500.12854/53834 23 01 0830 https://directory.doabooks.org/handle/20.500.12854/53834 24 01 0008 https://directory.doabooks.org/handle/20.500.12854/53834 30 01 0104 https://directory.doabooks.org/handle/20.500.12854/53834 31 01 0027 https://directory.doabooks.org/handle/20.500.12854/53834 40 01 0007 Volltext, Open Access https://directory.doabooks.org/handle/20.500.12854/53834 60 01 0705 https://directory.doabooks.org/handle/20.500.12854/53834 63 01 3401 E-Book https://directory.doabooks.org/handle/20.500.12854/53834 65 01 0003 Open Access https://directory.doabooks.org/handle/20.500.12854/53834 65 01 0003 Dieser Titel ist Teil einer Datenbank http://www.bibliothek.uni-regensburg.de/dbinfo/detail.php?titel_id=11367&bib_id=ulb_hal 70 01 0089 https://directory.doabooks.org/handle/20.500.12854/53834 72 01 0035 https://directory.doabooks.org/handle/20.500.12854/53834 90 01 3090 https://directory.doabooks.org/handle/20.500.12854/53834 91 01 3091 https://directory.doabooks.org/handle/20.500.12854/53834 92 01 0033 https://directory.doabooks.org/handle/20.500.12854/53834 95 01 3095 https://directory.doabooks.org/handle/20.500.12854/53834 105 01 0841 https://directory.doabooks.org/handle/20.500.12854/53834 110 01 3110 Open Access https://directory.doabooks.org/handle/20.500.12854/53834 120 01 0715 http://49gbv-uob-primo.hosted.exlibrisgroup.com/openurl/49GBV_UOB/UOB_services_page?u.ignore_date_coverage=true&rft.mms_id=991015556438203501 130 01 0700 Open Access https://directory.doabooks.org/handle/20.500.12854/53834 131 01 3131 https://directory.doabooks.org/handle/20.500.12854/53834 132 01 0959 https://directory.doabooks.org/handle/20.500.12854/53834 136 01 3526 Open Access https://directory.doabooks.org/handle/20.500.12854/53834 147 01 3528 https://directory.doabooks.org/handle/20.500.12854/53834 161 01 0960 https://directory.doabooks.org/handle/20.500.12854/53834 LF 213 01 0551 https://directory.doabooks.org/handle/20.500.12854/53834 230 01 0552 https://directory.doabooks.org/handle/20.500.12854/53834 283 01 3283 https://directory.doabooks.org/handle/20.500.12854/53834 285 01 0517 Open Access https://directory.doabooks.org/handle/20.500.12854/53834 293 01 3293 https://directory.doabooks.org/handle/20.500.12854/53834 LF 370 01 4370 https://directory.doabooks.org/handle/20.500.12854/53834 635 01 3635 https://directory.doabooks.org/handle/20.500.12854/53834 808 01 4808 Volltextzugang https://directory.doabooks.org/handle/20.500.12854/53834 2011 01 DE-16 https://directory.doabooks.org/handle/20.500.12854/53834 2014 01 DE-90 Volltext frei verfügbar https://directory.doabooks.org/handle/20.500.12854/53834 2034 01 DE-Rt2 https://directory.doabooks.org/handle/20.500.12854/53834 2037 01 DE-747 https://directory.doabooks.org/handle/20.500.12854/53834 2050 01 DE-Zi4 https://directory.doabooks.org/handle/20.500.12854/53834 2108 01 DE-991 https://directory.doabooks.org/handle/20.500.12854/53834 2403 01 DE-LFER https://directory.doabooks.org/handle/20.500.12854/53834 31 01 0027 00 E-Book Open Access 132 01 0959 00 EBooks DOAB Open Access 20 01 0084 OLR-DOAB 22 01 0018 OLR-ZDB-94-OAB 23 01 0830 olr-doab 24 01 0008 OLR-doab 24 01 0008 olr-frei 30 01 0104 OLR-OAB 31 01 0027 OLR-DOAB 39 01 0547 OLR-ZDB-94-OAB 39 01 0547 LF 40 01 0007 OLR-DOAB 60 01 0705 OPENAccess 63 01 3401 E-Books LF GBV-DOAB 65 01 0003 OLR-DOAB 70 01 0089 OLR-DOAB-OA 72 01 0035 OLR-ZDB-94-OAB 90 01 3090 OLR-HILoapen 91 01 3091 OLR-DOAB 92 01 0033 OLR-Open Access DOAB 95 01 3095 OLR-OAB 105 01 0841 OLR-OAB 110 01 3110 OLR-DOAB 120 01 0715 alma 130 01 0700 OLR-DOAB 131 01 3131 OLR-OA-DOAB 132 01 0959 OLR-OAB 136 01 3526 OLR-DOAB 147 01 3528 OLR-DOAB 161 01 0960 OLR-DOAB 213 01 0551 OLR-DOAB 230 01 0552 OLR-DOAB 285 01 0517 OLR-DOAB 293 01 3293 OLR-DOAB 370 01 4370 OLR-FREE 370 01 4370 olr-ebook ZDB-94-OAB 635 01 3635 OLR-DOAB 808 01 4808 OLR-DOAB |
| allfields_unstemmed |
9782889451333 978-2-88945-133-3 20.500.12854/53834 hdl (DE-627)1778565255 (DE-599)KEP069632316 (OCoLC)1002254070 (DOAB)53834 (EBP)069632316 DE-627 ger DE-627 rakwb eng Pedro Roda-Navarro verfasserin aut Molecular Dynamics at the Immunological Synapse [Erscheinungsort nicht ermittelbar] Frontiers Media SA 2017 1 Online-Ressource (120 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Frontiers Research Topics Open Access Unrestricted online access star The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies Creative Commons https://creativecommons.org/licenses/by/4.0 cc English Andres Alcover verfasserin aut Vincenzo Di Bartolo verfasserin aut https://directory.doabooks.org/handle/20.500.12854/53834 X:DOAB Verlag kostenfrei ZDB-94-OAB GBV_ILN_11 ISIL_DE-1a SYSFLAG_1 GBV_KXP GBV_ILN_20 ISIL_DE-84 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_60 ISIL_DE-705 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_91 ISIL_DE-HIL3 GBV_ILN_92 ISIL_DE-33 GBV_ILN_95 ISIL_DE-542 GBV_ILN_105 ISIL_DE-841 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_120 ISIL_DE-715 GBV_ILN_130 ISIL_DE-700 GBV_ILN_131 ISIL_DE-Va1 GBV_ILN_132 ISIL_DE-959 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_285 ISIL_DE-517 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_635 ISIL_DE-B2138 GBV_ILN_808 GBV_ILN_2011 ISIL_DE-16 GBV_ILN_2014 ISIL_DE-90 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2034 ISIL_DE-Rt2 GBV_ILN_2037 ISIL_DE-747 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2108 ISIL_DE-991 GBV_ILN_2403 ISIL_DE-LFER BO 11 01 0001 4023417858 00 5:LIZFREI --%%-- --%%-- --%%-- k 21-12-21 20 01 0084 4012090933 OLR-DOAB z 02-12-21 22 01 0018 4006182341 OLR-ZDB-94-OAB DOAB Directory of Open Access Books zu 25-11-21 23 01 0830 4006700245 olr-doab f z 25-11-21 24 01 0008 4060182915 OLR-doab z 15-02-22 30 01 0104 4102264787 OLR-OAB Open Access, Directory of Open Access Books (DOAB) z 26-03-22 31 01 0027 4052520319 OLR-DOAB z 07-02-22 39 01 0547 4106001322 OLR-ZDB-94-OAB ke 29-03-22 40 01 0007 4011655589 OLR-DOAB xsn 01-12-21 60 01 0705 4276008328 OPENAccess Vervielfältigungen (z.B. 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Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 11-04-24 808 01 4808 4158159938 OLR-DOAB DOAB Directory of Open Access Books zg 29-06-22 2011 01 DE-16 4022767960 00 --%%-- --%%-- --%%-- --%%-- l01 20-12-21 2014 01 DE-90 4010971215 00 --%%-- --%%-- --%%-- --%%-- l01 01-12-21 2018 01 DE-31 4033330488 00 --%%-- --%%-- --%%-- n Der Zugriff ist kostenfrei möglich. l01 11-01-22 2034 01 DE-Rt2 4013972336 00 --%%-- eBook n n frei zugänglich l01 04-12-21 2037 01 DE-747 4346269656 00 --%%-- eBook OAPEN Foundation OpenAccess --%%-- n Im Internet frei verfügbar l01 01-07-23 2050 01 DE-Zi4 4091499953 00 --%%-- --%%-- --%%-- n Elektronischer Volltext - Open Access l01 16-03-22 2108 01 DE-991 4096651672 00 --%%-- eBook DOAB --%%-- n Elektronischer Volltext - Campuslizenz l01 19-03-22 2403 01 DE-LFER 4019060975 00 --%%-- --%%-- n --%%-- l01 11-12-21 20 01 0084 https://directory.doabooks.org/handle/20.500.12854/53834 22 01 0018 Volltextzugang https://directory.doabooks.org/handle/20.500.12854/53834 23 01 0830 https://directory.doabooks.org/handle/20.500.12854/53834 24 01 0008 https://directory.doabooks.org/handle/20.500.12854/53834 30 01 0104 https://directory.doabooks.org/handle/20.500.12854/53834 31 01 0027 https://directory.doabooks.org/handle/20.500.12854/53834 40 01 0007 Volltext, Open Access https://directory.doabooks.org/handle/20.500.12854/53834 60 01 0705 https://directory.doabooks.org/handle/20.500.12854/53834 63 01 3401 E-Book https://directory.doabooks.org/handle/20.500.12854/53834 65 01 0003 Open Access https://directory.doabooks.org/handle/20.500.12854/53834 65 01 0003 Dieser Titel ist Teil einer Datenbank http://www.bibliothek.uni-regensburg.de/dbinfo/detail.php?titel_id=11367&bib_id=ulb_hal 70 01 0089 https://directory.doabooks.org/handle/20.500.12854/53834 72 01 0035 https://directory.doabooks.org/handle/20.500.12854/53834 90 01 3090 https://directory.doabooks.org/handle/20.500.12854/53834 91 01 3091 https://directory.doabooks.org/handle/20.500.12854/53834 92 01 0033 https://directory.doabooks.org/handle/20.500.12854/53834 95 01 3095 https://directory.doabooks.org/handle/20.500.12854/53834 105 01 0841 https://directory.doabooks.org/handle/20.500.12854/53834 110 01 3110 Open Access https://directory.doabooks.org/handle/20.500.12854/53834 120 01 0715 http://49gbv-uob-primo.hosted.exlibrisgroup.com/openurl/49GBV_UOB/UOB_services_page?u.ignore_date_coverage=true&rft.mms_id=991015556438203501 130 01 0700 Open Access https://directory.doabooks.org/handle/20.500.12854/53834 131 01 3131 https://directory.doabooks.org/handle/20.500.12854/53834 132 01 0959 https://directory.doabooks.org/handle/20.500.12854/53834 136 01 3526 Open Access https://directory.doabooks.org/handle/20.500.12854/53834 147 01 3528 https://directory.doabooks.org/handle/20.500.12854/53834 161 01 0960 https://directory.doabooks.org/handle/20.500.12854/53834 LF 213 01 0551 https://directory.doabooks.org/handle/20.500.12854/53834 230 01 0552 https://directory.doabooks.org/handle/20.500.12854/53834 283 01 3283 https://directory.doabooks.org/handle/20.500.12854/53834 285 01 0517 Open Access https://directory.doabooks.org/handle/20.500.12854/53834 293 01 3293 https://directory.doabooks.org/handle/20.500.12854/53834 LF 370 01 4370 https://directory.doabooks.org/handle/20.500.12854/53834 635 01 3635 https://directory.doabooks.org/handle/20.500.12854/53834 808 01 4808 Volltextzugang https://directory.doabooks.org/handle/20.500.12854/53834 2011 01 DE-16 https://directory.doabooks.org/handle/20.500.12854/53834 2014 01 DE-90 Volltext frei verfügbar https://directory.doabooks.org/handle/20.500.12854/53834 2034 01 DE-Rt2 https://directory.doabooks.org/handle/20.500.12854/53834 2037 01 DE-747 https://directory.doabooks.org/handle/20.500.12854/53834 2050 01 DE-Zi4 https://directory.doabooks.org/handle/20.500.12854/53834 2108 01 DE-991 https://directory.doabooks.org/handle/20.500.12854/53834 2403 01 DE-LFER https://directory.doabooks.org/handle/20.500.12854/53834 31 01 0027 00 E-Book Open Access 132 01 0959 00 EBooks DOAB Open Access 20 01 0084 OLR-DOAB 22 01 0018 OLR-ZDB-94-OAB 23 01 0830 olr-doab 24 01 0008 OLR-doab 24 01 0008 olr-frei 30 01 0104 OLR-OAB 31 01 0027 OLR-DOAB 39 01 0547 OLR-ZDB-94-OAB 39 01 0547 LF 40 01 0007 OLR-DOAB 60 01 0705 OPENAccess 63 01 3401 E-Books LF GBV-DOAB 65 01 0003 OLR-DOAB 70 01 0089 OLR-DOAB-OA 72 01 0035 OLR-ZDB-94-OAB 90 01 3090 OLR-HILoapen 91 01 3091 OLR-DOAB 92 01 0033 OLR-Open Access DOAB 95 01 3095 OLR-OAB 105 01 0841 OLR-OAB 110 01 3110 OLR-DOAB 120 01 0715 alma 130 01 0700 OLR-DOAB 131 01 3131 OLR-OA-DOAB 132 01 0959 OLR-OAB 136 01 3526 OLR-DOAB 147 01 3528 OLR-DOAB 161 01 0960 OLR-DOAB 213 01 0551 OLR-DOAB 230 01 0552 OLR-DOAB 285 01 0517 OLR-DOAB 293 01 3293 OLR-DOAB 370 01 4370 OLR-FREE 370 01 4370 olr-ebook ZDB-94-OAB 635 01 3635 OLR-DOAB 808 01 4808 OLR-DOAB |
| allfieldsGer |
9782889451333 978-2-88945-133-3 20.500.12854/53834 hdl (DE-627)1778565255 (DE-599)KEP069632316 (OCoLC)1002254070 (DOAB)53834 (EBP)069632316 DE-627 ger DE-627 rakwb eng Pedro Roda-Navarro verfasserin aut Molecular Dynamics at the Immunological Synapse [Erscheinungsort nicht ermittelbar] Frontiers Media SA 2017 1 Online-Ressource (120 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Frontiers Research Topics Open Access Unrestricted online access star The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies Creative Commons https://creativecommons.org/licenses/by/4.0 cc English Andres Alcover verfasserin aut Vincenzo Di Bartolo verfasserin aut https://directory.doabooks.org/handle/20.500.12854/53834 X:DOAB Verlag kostenfrei ZDB-94-OAB GBV_ILN_11 ISIL_DE-1a SYSFLAG_1 GBV_KXP GBV_ILN_20 ISIL_DE-84 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_60 ISIL_DE-705 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_91 ISIL_DE-HIL3 GBV_ILN_92 ISIL_DE-33 GBV_ILN_95 ISIL_DE-542 GBV_ILN_105 ISIL_DE-841 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_120 ISIL_DE-715 GBV_ILN_130 ISIL_DE-700 GBV_ILN_131 ISIL_DE-Va1 GBV_ILN_132 ISIL_DE-959 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_285 ISIL_DE-517 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_635 ISIL_DE-B2138 GBV_ILN_808 GBV_ILN_2011 ISIL_DE-16 GBV_ILN_2014 ISIL_DE-90 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2034 ISIL_DE-Rt2 GBV_ILN_2037 ISIL_DE-747 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2108 ISIL_DE-991 GBV_ILN_2403 ISIL_DE-LFER BO 11 01 0001 4023417858 00 5:LIZFREI --%%-- --%%-- --%%-- k 21-12-21 20 01 0084 4012090933 OLR-DOAB z 02-12-21 22 01 0018 4006182341 OLR-ZDB-94-OAB DOAB Directory of Open Access Books zu 25-11-21 23 01 0830 4006700245 olr-doab f z 25-11-21 24 01 0008 4060182915 OLR-doab z 15-02-22 30 01 0104 4102264787 OLR-OAB Open Access, Directory of Open Access Books (DOAB) z 26-03-22 31 01 0027 4052520319 OLR-DOAB z 07-02-22 39 01 0547 4106001322 OLR-ZDB-94-OAB ke 29-03-22 40 01 0007 4011655589 OLR-DOAB xsn 01-12-21 60 01 0705 4276008328 OPENAccess Vervielfältigungen (z.B. 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| allfieldsSound |
9782889451333 978-2-88945-133-3 20.500.12854/53834 hdl (DE-627)1778565255 (DE-599)KEP069632316 (OCoLC)1002254070 (DOAB)53834 (EBP)069632316 DE-627 ger DE-627 rakwb eng Pedro Roda-Navarro verfasserin aut Molecular Dynamics at the Immunological Synapse [Erscheinungsort nicht ermittelbar] Frontiers Media SA 2017 1 Online-Ressource (120 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Frontiers Research Topics Open Access Unrestricted online access star The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies Creative Commons https://creativecommons.org/licenses/by/4.0 cc English Andres Alcover verfasserin aut Vincenzo Di Bartolo verfasserin aut https://directory.doabooks.org/handle/20.500.12854/53834 X:DOAB Verlag kostenfrei ZDB-94-OAB GBV_ILN_11 ISIL_DE-1a SYSFLAG_1 GBV_KXP GBV_ILN_20 ISIL_DE-84 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_60 ISIL_DE-705 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_91 ISIL_DE-HIL3 GBV_ILN_92 ISIL_DE-33 GBV_ILN_95 ISIL_DE-542 GBV_ILN_105 ISIL_DE-841 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_120 ISIL_DE-715 GBV_ILN_130 ISIL_DE-700 GBV_ILN_131 ISIL_DE-Va1 GBV_ILN_132 ISIL_DE-959 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_285 ISIL_DE-517 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_635 ISIL_DE-B2138 GBV_ILN_808 GBV_ILN_2011 ISIL_DE-16 GBV_ILN_2014 ISIL_DE-90 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2034 ISIL_DE-Rt2 GBV_ILN_2037 ISIL_DE-747 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2108 ISIL_DE-991 GBV_ILN_2403 ISIL_DE-LFER BO 11 01 0001 4023417858 00 5:LIZFREI --%%-- --%%-- --%%-- k 21-12-21 20 01 0084 4012090933 OLR-DOAB z 02-12-21 22 01 0018 4006182341 OLR-ZDB-94-OAB DOAB Directory of Open Access Books zu 25-11-21 23 01 0830 4006700245 olr-doab f z 25-11-21 24 01 0008 4060182915 OLR-doab z 15-02-22 30 01 0104 4102264787 OLR-OAB Open Access, Directory of Open Access Books (DOAB) z 26-03-22 31 01 0027 4052520319 OLR-DOAB z 07-02-22 39 01 0547 4106001322 OLR-ZDB-94-OAB ke 29-03-22 40 01 0007 4011655589 OLR-DOAB xsn 01-12-21 60 01 0705 4276008328 OPENAccess Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots. 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Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. Das Ebook ist frei zugänglich. z 02-04-22 95 01 3095 4342276267 OLR-OAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 23-06-23 105 01 0841 4007161275 OLR-OAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 25-11-21 110 01 3110 4019861064 OLR-DOAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. 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code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">02-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">22</subfield><subfield code="1">01</subfield><subfield code="x">0018</subfield><subfield code="b">4006182341</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">zu</subfield><subfield code="z">25-11-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">23</subfield><subfield code="1">01</subfield><subfield code="x">0830</subfield><subfield code="b">4006700245</subfield><subfield code="h">olr-doab</subfield><subfield code="u">f</subfield><subfield code="y">z</subfield><subfield code="z">25-11-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">24</subfield><subfield code="1">01</subfield><subfield code="x">0008</subfield><subfield code="b">4060182915</subfield><subfield code="h">OLR-doab</subfield><subfield code="y">z</subfield><subfield code="z">15-02-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">30</subfield><subfield code="1">01</subfield><subfield code="x">0104</subfield><subfield code="b">4102264787</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Open Access, Directory of Open Access Books (DOAB)</subfield><subfield code="y">z</subfield><subfield code="z">26-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">31</subfield><subfield code="1">01</subfield><subfield code="x">0027</subfield><subfield code="b">4052520319</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">07-02-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">39</subfield><subfield code="1">01</subfield><subfield code="x">0547</subfield><subfield code="b">4106001322</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="y">ke</subfield><subfield code="z">29-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">40</subfield><subfield code="1">01</subfield><subfield code="x">0007</subfield><subfield code="b">4011655589</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">xsn</subfield><subfield code="z">01-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">60</subfield><subfield code="1">01</subfield><subfield code="x">0705</subfield><subfield code="b">4276008328</subfield><subfield code="h">OPENAccess</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots.</subfield><subfield code="k">Nur für Angehörige der HSU: Volltextzugang von außerhalb des Campus mit Anmeldung über Shibboleth mit Ihrer Bibliothekskennung</subfield><subfield code="y">z</subfield><subfield code="z">24-02-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">63</subfield><subfield code="1">01</subfield><subfield code="x">3401</subfield><subfield code="b">4106635798</subfield><subfield code="h">E-Books LF GBV-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">30-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">65</subfield><subfield code="1">01</subfield><subfield code="x">0003</subfield><subfield code="b">4109332532</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Nach dem deutschen Urheberrecht darf das Werk bzw. der Inhalt zum eigenen Gebrauch kostenfrei heruntergeladen, konsumiert, gespeichert oder ausgedruckt, nicht jedoch im Internet bereitgestellt oder an Außenstehende weitergegeben werden!</subfield><subfield code="y">z</subfield><subfield code="z">01-04-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">70</subfield><subfield code="1">01</subfield><subfield code="x">0089</subfield><subfield code="b">4006438931</subfield><subfield code="h">OLR-DOAB-OA</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">25-11-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">72</subfield><subfield code="1">01</subfield><subfield code="x">0035</subfield><subfield code="b">4104687782</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">28-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">90</subfield><subfield code="1">01</subfield><subfield code="x">3090</subfield><subfield code="b">4106427532</subfield><subfield code="h">OLR-HILoapen</subfield><subfield code="y">z</subfield><subfield code="z">29-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">91</subfield><subfield code="1">01</subfield><subfield code="x">3091</subfield><subfield code="b">4011407429</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">01-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">92</subfield><subfield code="1">01</subfield><subfield code="x">0033</subfield><subfield code="b">4110784026</subfield><subfield code="h">OLR-Open Access DOAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. Das Ebook ist frei zugänglich.</subfield><subfield code="y">z</subfield><subfield code="z">02-04-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">95</subfield><subfield code="1">01</subfield><subfield code="x">3095</subfield><subfield code="b">4342276267</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">23-06-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">105</subfield><subfield code="1">01</subfield><subfield code="x">0841</subfield><subfield code="b">4007161275</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">25-11-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">110</subfield><subfield code="1">01</subfield><subfield code="x">3110</subfield><subfield code="b">4019861064</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="k">Open Access</subfield><subfield code="y">z</subfield><subfield code="z">14-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">120</subfield><subfield code="1">01</subfield><subfield code="x">0715</subfield><subfield code="b">4015103742</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">g</subfield><subfield code="j">--%%--</subfield><subfield code="h">alma</subfield><subfield code="y">z</subfield><subfield code="z">07-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">130</subfield><subfield code="1">01</subfield><subfield code="x">0700</subfield><subfield code="b">4145857402</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">08-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">131</subfield><subfield code="1">01</subfield><subfield code="x">3131</subfield><subfield code="b">4465805454</subfield><subfield code="h">OLR-OA-DOAB</subfield><subfield code="k">Bitte beachten Sie die Nutzungsbedingungen und Copyright-Bestimmungen des Verlages/Herausgebers.</subfield><subfield code="y">z</subfield><subfield code="z">23-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">132</subfield><subfield code="1">01</subfield><subfield code="x">0959</subfield><subfield code="b">4149794073</subfield><subfield code="h">OLR-OAB</subfield><subfield code="u">Open Access</subfield><subfield code="y">x</subfield><subfield code="z">14-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">136</subfield><subfield code="1">01</subfield><subfield code="x">3526</subfield><subfield code="b">4005724574</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">24-11-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">147</subfield><subfield code="1">01</subfield><subfield code="x">3528</subfield><subfield code="b">4124044003</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">frei verfügbar für Europa-Universität Flensburg, Hochschule Flensburg und Zentrale Hochschulbibliothek</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">27-04-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">161</subfield><subfield code="1">01</subfield><subfield code="x">0960</subfield><subfield code="b">4150965951</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">16-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">213</subfield><subfield code="1">01</subfield><subfield code="x">0551</subfield><subfield code="b">4108644743</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">31-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">230</subfield><subfield code="1">01</subfield><subfield code="x">0552</subfield><subfield code="b">4123543278</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">27-04-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">283</subfield><subfield code="1">01</subfield><subfield code="x">3283</subfield><subfield code="b">4157121872</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">28-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">285</subfield><subfield code="1">01</subfield><subfield code="x">0517</subfield><subfield code="b">4050349736</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">03-02-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">293</subfield><subfield code="1">01</subfield><subfield code="x">3293</subfield><subfield code="b">4153762806</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">21-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">370</subfield><subfield code="1">01</subfield><subfield code="x">4370</subfield><subfield code="b">4125616906</subfield><subfield code="h">OLR-FREE</subfield><subfield code="k">Kostenloser Zugriff</subfield><subfield code="y">z</subfield><subfield code="z">28-04-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">635</subfield><subfield code="1">01</subfield><subfield code="x">3635</subfield><subfield code="b">4509926065</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Open Access. Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">11-04-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">808</subfield><subfield code="1">01</subfield><subfield code="x">4808</subfield><subfield code="b">4158159938</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">zg</subfield><subfield code="z">29-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2011</subfield><subfield code="1">01</subfield><subfield code="x">DE-16</subfield><subfield code="b">4022767960</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">20-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2014</subfield><subfield code="1">01</subfield><subfield code="x">DE-90</subfield><subfield code="b">4010971215</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">01-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2018</subfield><subfield code="1">01</subfield><subfield code="x">DE-31</subfield><subfield code="b">4033330488</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Der Zugriff ist kostenfrei möglich.</subfield><subfield code="y">l01</subfield><subfield code="z">11-01-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2034</subfield><subfield code="1">01</subfield><subfield code="x">DE-Rt2</subfield><subfield code="b">4013972336</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook</subfield><subfield code="e">n</subfield><subfield code="j">n</subfield><subfield code="k">frei zugänglich</subfield><subfield code="y">l01</subfield><subfield code="z">04-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2037</subfield><subfield code="1">01</subfield><subfield code="x">DE-747</subfield><subfield code="b">4346269656</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook OAPEN Foundation OpenAccess</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Im Internet frei verfügbar</subfield><subfield code="y">l01</subfield><subfield code="z">01-07-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2050</subfield><subfield code="1">01</subfield><subfield code="x">DE-Zi4</subfield><subfield code="b">4091499953</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - Open Access</subfield><subfield code="y">l01</subfield><subfield code="z">16-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2108</subfield><subfield code="1">01</subfield><subfield code="x">DE-991</subfield><subfield code="b">4096651672</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook DOAB</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - Campuslizenz</subfield><subfield code="y">l01</subfield><subfield code="z">19-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2403</subfield><subfield code="1">01</subfield><subfield code="x">DE-LFER</subfield><subfield code="b">4019060975</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">n</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">11-12-21</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">20</subfield><subfield code="1">01</subfield><subfield code="x">0084</subfield><subfield code="r">https://directory.doabooks.org/handle/20.500.12854/53834</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">22</subfield><subfield code="1">01</subfield><subfield code="x">0018</subfield><subfield code="y">Volltextzugang</subfield><subfield code="r">https://directory.doabooks.org/handle/20.500.12854/53834</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">23</subfield><subfield code="1">01</subfield><subfield code="x">0830</subfield><subfield code="r">https://directory.doabooks.org/handle/20.500.12854/53834</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">24</subfield><subfield code="1">01</subfield><subfield code="x">0008</subfield><subfield code="r">https://directory.doabooks.org/handle/20.500.12854/53834</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">30</subfield><subfield code="1">01</subfield><subfield code="x">0104</subfield><subfield code="r">https://directory.doabooks.org/handle/20.500.12854/53834</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">31</subfield><subfield code="1">01</subfield><subfield code="x">0027</subfield><subfield code="r">https://directory.doabooks.org/handle/20.500.12854/53834</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">40</subfield><subfield code="1">01</subfield><subfield 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Molecular Dynamics at the Immunological Synapse |
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Pedro Roda-Navarro |
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molecular dynamics at the immunological synapse |
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Molecular Dynamics at the Immunological Synapse |
| abstract |
The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies |
| abstractGer |
The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies |
| abstract_unstemmed |
The immunological synapse (IS) is a specialised cell-cell adhesion that mediates antigen acquisition and regulates the activation of lymphocytes. Initial studies of the IS showed a structure composed of stable supra-molecular activation clusters (SMAC) organised during the interaction of helper T lymphocytes with B lymphocytes, working as antigen presenting cells. A central SMAC of coalesced T cell receptors (TCRs) and a peripheral SMAC for cell-cell adhesion were observed. IS with similar structure was later described during antigen acquisition by B cells and during the interaction of NK cells with target and healthy cells. More recent research developed with microscopy systems that improve the spatial and temporal resolution has showed the complex molecular dynamics at the IS that governs lymphocyte activation. Currently, the IS is seen as a three-dimensional structure where signalling networks for lymphocyte activation and endosomal and cytoskeleton machinery are polarised. A view has emerged in which dynamic microclusters of signalling complexes are composed of molecular components attached to the plasma membrane and other components conveyed on sub-synaptic vesicles transported to the membrane by cytoskeletal fibers and motor proteins. Much information is nonetheless missing about how the dynamics of the endosomal compartment, the cytoskeleton, and signalling complexes are reciprocally regulated to achieve the function of lymphocytes. Experimental evidence also suggests that the environment surrounding lymphocytes exposed to different antigenic challenge regulates IS assembly and functional output, making an even more complex scenario still far from being completely understood. Also, although some signalling molecular components for lymphocyte activation have been identified and thoroughly studied, the function of other molecules has not been yet uncovered or deeply characterised. This research topic aims to provide the reader with the latest information about the molecular dynamics governing lymphocyte activation. These molecular dynamics dictate cell decisions. Thus, we expect that understanding them will provide new avenues for cell manipulation in therapies to treat different immune-related pathologies |
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tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-991</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2403</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-LFER</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">BO</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">11</subfield><subfield code="1">01</subfield><subfield code="x">0001</subfield><subfield code="b">4023417858</subfield><subfield code="c">00</subfield><subfield code="f">5:LIZFREI</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">k</subfield><subfield code="z">21-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">20</subfield><subfield code="1">01</subfield><subfield code="x">0084</subfield><subfield code="b">4012090933</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">02-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">22</subfield><subfield code="1">01</subfield><subfield code="x">0018</subfield><subfield code="b">4006182341</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">zu</subfield><subfield code="z">25-11-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">23</subfield><subfield code="1">01</subfield><subfield code="x">0830</subfield><subfield code="b">4006700245</subfield><subfield code="h">olr-doab</subfield><subfield code="u">f</subfield><subfield code="y">z</subfield><subfield code="z">25-11-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">24</subfield><subfield code="1">01</subfield><subfield code="x">0008</subfield><subfield code="b">4060182915</subfield><subfield code="h">OLR-doab</subfield><subfield code="y">z</subfield><subfield code="z">15-02-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">30</subfield><subfield code="1">01</subfield><subfield code="x">0104</subfield><subfield code="b">4102264787</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Open Access, Directory of Open Access Books (DOAB)</subfield><subfield code="y">z</subfield><subfield code="z">26-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">31</subfield><subfield code="1">01</subfield><subfield code="x">0027</subfield><subfield code="b">4052520319</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">07-02-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">39</subfield><subfield code="1">01</subfield><subfield code="x">0547</subfield><subfield code="b">4106001322</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="y">ke</subfield><subfield code="z">29-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">40</subfield><subfield code="1">01</subfield><subfield code="x">0007</subfield><subfield code="b">4011655589</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">xsn</subfield><subfield code="z">01-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">60</subfield><subfield code="1">01</subfield><subfield code="x">0705</subfield><subfield code="b">4276008328</subfield><subfield code="h">OPENAccess</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots.</subfield><subfield code="k">Nur für Angehörige der HSU: Volltextzugang von außerhalb des Campus mit Anmeldung über Shibboleth mit Ihrer Bibliothekskennung</subfield><subfield code="y">z</subfield><subfield code="z">24-02-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">63</subfield><subfield code="1">01</subfield><subfield code="x">3401</subfield><subfield code="b">4106635798</subfield><subfield code="h">E-Books LF GBV-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">30-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">65</subfield><subfield code="1">01</subfield><subfield code="x">0003</subfield><subfield code="b">4109332532</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Nach dem deutschen Urheberrecht darf das Werk bzw. der Inhalt zum eigenen Gebrauch kostenfrei heruntergeladen, konsumiert, gespeichert oder ausgedruckt, nicht jedoch im Internet bereitgestellt oder an Außenstehende weitergegeben werden!</subfield><subfield code="y">z</subfield><subfield code="z">01-04-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">70</subfield><subfield code="1">01</subfield><subfield code="x">0089</subfield><subfield code="b">4006438931</subfield><subfield code="h">OLR-DOAB-OA</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">25-11-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">72</subfield><subfield code="1">01</subfield><subfield code="x">0035</subfield><subfield code="b">4104687782</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">28-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">90</subfield><subfield code="1">01</subfield><subfield code="x">3090</subfield><subfield code="b">4106427532</subfield><subfield code="h">OLR-HILoapen</subfield><subfield code="y">z</subfield><subfield code="z">29-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">91</subfield><subfield code="1">01</subfield><subfield code="x">3091</subfield><subfield code="b">4011407429</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">01-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">92</subfield><subfield code="1">01</subfield><subfield code="x">0033</subfield><subfield code="b">4110784026</subfield><subfield code="h">OLR-Open Access DOAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. Das Ebook ist frei zugänglich.</subfield><subfield code="y">z</subfield><subfield code="z">02-04-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">95</subfield><subfield code="1">01</subfield><subfield code="x">3095</subfield><subfield code="b">4342276267</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">23-06-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">105</subfield><subfield code="1">01</subfield><subfield code="x">0841</subfield><subfield code="b">4007161275</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">25-11-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">110</subfield><subfield code="1">01</subfield><subfield code="x">3110</subfield><subfield code="b">4019861064</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="k">Open Access</subfield><subfield code="y">z</subfield><subfield code="z">14-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">120</subfield><subfield code="1">01</subfield><subfield code="x">0715</subfield><subfield code="b">4015103742</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">g</subfield><subfield code="j">--%%--</subfield><subfield code="h">alma</subfield><subfield code="y">z</subfield><subfield code="z">07-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">130</subfield><subfield code="1">01</subfield><subfield code="x">0700</subfield><subfield code="b">4145857402</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">08-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">131</subfield><subfield code="1">01</subfield><subfield code="x">3131</subfield><subfield code="b">4465805454</subfield><subfield code="h">OLR-OA-DOAB</subfield><subfield code="k">Bitte beachten Sie die Nutzungsbedingungen und Copyright-Bestimmungen des Verlages/Herausgebers.</subfield><subfield code="y">z</subfield><subfield code="z">23-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">132</subfield><subfield code="1">01</subfield><subfield code="x">0959</subfield><subfield code="b">4149794073</subfield><subfield code="h">OLR-OAB</subfield><subfield code="u">Open Access</subfield><subfield code="y">x</subfield><subfield code="z">14-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">136</subfield><subfield code="1">01</subfield><subfield code="x">3526</subfield><subfield code="b">4005724574</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">24-11-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">147</subfield><subfield code="1">01</subfield><subfield code="x">3528</subfield><subfield code="b">4124044003</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">frei verfügbar für Europa-Universität Flensburg, Hochschule Flensburg und Zentrale Hochschulbibliothek</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">27-04-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">161</subfield><subfield code="1">01</subfield><subfield code="x">0960</subfield><subfield code="b">4150965951</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">16-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">213</subfield><subfield code="1">01</subfield><subfield code="x">0551</subfield><subfield code="b">4108644743</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">31-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">230</subfield><subfield code="1">01</subfield><subfield code="x">0552</subfield><subfield code="b">4123543278</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">27-04-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">283</subfield><subfield code="1">01</subfield><subfield code="x">3283</subfield><subfield code="b">4157121872</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">28-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">285</subfield><subfield code="1">01</subfield><subfield code="x">0517</subfield><subfield code="b">4050349736</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">03-02-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">293</subfield><subfield code="1">01</subfield><subfield code="x">3293</subfield><subfield code="b">4153762806</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">21-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">370</subfield><subfield code="1">01</subfield><subfield code="x">4370</subfield><subfield code="b">4125616906</subfield><subfield code="h">OLR-FREE</subfield><subfield code="k">Kostenloser Zugriff</subfield><subfield code="y">z</subfield><subfield code="z">28-04-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">635</subfield><subfield code="1">01</subfield><subfield code="x">3635</subfield><subfield code="b">4509926065</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Open Access. Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">11-04-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">808</subfield><subfield code="1">01</subfield><subfield code="x">4808</subfield><subfield code="b">4158159938</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">zg</subfield><subfield code="z">29-06-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2011</subfield><subfield code="1">01</subfield><subfield code="x">DE-16</subfield><subfield code="b">4022767960</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">20-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2014</subfield><subfield code="1">01</subfield><subfield code="x">DE-90</subfield><subfield code="b">4010971215</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">01-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2018</subfield><subfield code="1">01</subfield><subfield code="x">DE-31</subfield><subfield code="b">4033330488</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Der Zugriff ist kostenfrei möglich.</subfield><subfield code="y">l01</subfield><subfield code="z">11-01-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2034</subfield><subfield code="1">01</subfield><subfield code="x">DE-Rt2</subfield><subfield code="b">4013972336</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook</subfield><subfield code="e">n</subfield><subfield code="j">n</subfield><subfield code="k">frei zugänglich</subfield><subfield code="y">l01</subfield><subfield code="z">04-12-21</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2037</subfield><subfield code="1">01</subfield><subfield code="x">DE-747</subfield><subfield code="b">4346269656</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook OAPEN Foundation OpenAccess</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Im Internet frei verfügbar</subfield><subfield code="y">l01</subfield><subfield code="z">01-07-23</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2050</subfield><subfield code="1">01</subfield><subfield code="x">DE-Zi4</subfield><subfield code="b">4091499953</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - Open Access</subfield><subfield code="y">l01</subfield><subfield code="z">16-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2108</subfield><subfield code="1">01</subfield><subfield code="x">DE-991</subfield><subfield code="b">4096651672</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook DOAB</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - Campuslizenz</subfield><subfield code="y">l01</subfield><subfield code="z">19-03-22</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield 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