Chapter 7 Vitamin C in Pneumonia and Sepsis
In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by membe...
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| Autor*in: |
Carr, Anitra C. [verfasserIn] |
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| Format: |
E-Book |
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| Sprache: |
Englisch |
| Erschienen: |
Erscheinungsort nicht ermittelbar: Taylor & Francis ; 2020 |
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| Rechteinformationen: |
Open Access Creative Commons ; https://creativecommons.org/licenses/by-nc-nd/4.0 |
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1 Online-Ressource (26 p.) |
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| 520 | |a In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by members of the SLC23 family, SLC23A1/SVCT1 and SLC23A2/SVCT2. We present in silico models of these transporters that provide new insights into the structure of the SLC23 family. While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. In the future, SVCT1 and SVCT2 may furthermore prove useful as drug delivery systems, to enhance transport of novel pharmaceutical agents more efficiently across the intestinal epithelium and the blood-cerebrospinal fluid barrier | ||
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(DE-627)1836447507 (DE-599)KEP062186191 (OCoLC)1286318264 (OAPEN)40107 (EBP)062186191 DE-627 eng DE-627 rda eng MMG bicssc PSD bicssc PS bicssc MKG bicssc Carr, Anitra C. verfasserin aut Chapter 7 Vitamin C in Pneumonia and Sepsis [Erscheinungsort nicht ermittelbar] Taylor & Francis 2020 1 Online-Ressource (26 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Open Access Unrestricted online access star In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by members of the SLC23 family, SLC23A1/SVCT1 and SLC23A2/SVCT2. We present in silico models of these transporters that provide new insights into the structure of the SLC23 family. While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. In the future, SVCT1 and SVCT2 may furthermore prove useful as drug delivery systems, to enhance transport of novel pharmaceutical agents more efficiently across the intestinal epithelium and the blood-cerebrospinal fluid barrier Creative Commons https://creativecommons.org/licenses/by-nc-nd/4.0 cc English Pharmacology Molecular biology Biology, life sciences https://library.oapen.org/bitstream/id/b2319453-4f1d-4fa3-899c-e8d756eee652/9781138337992_oachapter7.pdf X:OAPEN Verlag OAPEN Library: download the publication kostenfrei https://library.oapen.org/handle/20.500.12657/40107 X:OAPEN Verlag OAPEN Library: description of the publication kostenfrei ZDB-94-OAL GBV_ILN_22 ISIL_DE-18 SYSFLAG_1 GBV_KXP GBV_ILN_23 ISIL_DE-830 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_34 ISIL_DE-18-302 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_95 ISIL_DE-542 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_187 ISIL_DE-Ki95 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_603 ISIL_DE-B1556 GBV_ILN_808 GBV_ILN_2403 ISIL_DE-LFER BO 22 01 0018 4280105642 OLR-ZDB-94-OAL OAPEN Library zu 01-03-23 23 01 0830 4280657645 OLR-OAPEN f z 01-03-23 30 01 0104 4281018018 GBV-OAPEN z 01-03-23 31 01 0027 4280300380 z 01-03-23 34 01 3551 4278855915 OLR-OAPEN zi002 01-03-23 39 01 0547 4281208836 GBV-OAPEN ke 01-03-23 40 01 0007 4279924414 OLR-OAPEN xsn 01-03-23 63 01 3401 4281589775 E-Books LF GBV-OAPEN z 01-03-23 65 01 0003 4281840885 OLR-OAPEN z 01-03-23 70 01 0089 4280478619 OLR-OAPEN-OA OAPEN Online Library Open Access eBook z 01-03-23 72 01 0035 4278676670 OLR-OAPEN-OA OAPEN Online Library Open Access eBook z 01-03-23 95 01 3095 4343204405 OLR-OAL Vervielfältigungen (z.B. 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Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 01-03-23 161 01 0960 4278112211 OLR-OAPEN OAPEN Online Library Open Access eBook z 28-02-23 187 01 3520 4278497083 JSTOR Open Access eBook z 28-02-23 213 01 0551 4279211094 OLR-OAPEN OAPEN Online Library Open Access eBook z 01-03-23 230 01 0552 427938827X OLR-OAPEN OAPEN Online Library Open Access eBook z 01-03-23 283 01 3283 4279747180 OLR-OAL z 01-03-23 293 01 3293 4278291302 OLR-OAPEN OAPEN Online Library Open Access eBook z 28-02-23 370 01 4370 4279033668 OLR-FREE Kostenloser Zugriff z 01-03-23 603 01 4603 4277934315 OLR-OAPEN Bitte beachten Sie die Nutzungsbedingungen und Copyright-Bestimmungen des Verlages/Herausgebers. z 28-02-23 808 01 4808 4280836558 OLR-OAPEN OAPEN Library zg 01-03-23 2403 01 DE-LFER 430752179X 00 --%%-- --%%-- n --%%-- l01 11-04-23 22 01 0018 Volltextzugang https://library.oapen.org/handle/20.500.12657/40107 23 01 0830 https://library.oapen.org/handle/20.500.12657/40107 30 01 0104 Open Access https://library.oapen.org/handle/20.500.12657/40107 31 01 0027 eBook GBV-OAPEN https://library.oapen.org/handle/20.500.12657/40107 34 01 3551 OpenAccess https://library.oapen.org/handle/20.500.12657/40107 40 01 0007 Volltext, Open Access https://library.oapen.org/handle/20.500.12657/40107 63 01 3401 E-Book https://library.oapen.org/handle/20.500.12657/40107 65 01 0003 Open Access https://library.oapen.org/handle/20.500.12657/40107 65 01 0003 Dieser Titel ist Teil einer Datenbank http://www.bibliothek.uni-regensburg.de/dbinfo/detail.php?titel_id=10728&bib_id=ulb_hal 70 01 0089 https://library.oapen.org/handle/20.500.12657/40107 LF 72 01 0035 https://library.oapen.org/handle/20.500.12657/40107 95 01 3095 https://library.oapen.org/handle/20.500.12657/40107 110 01 3110 Open Access https://library.oapen.org/handle/20.500.12657/40107 136 01 3526 Open Access https://library.oapen.org/handle/20.500.12657/40107 147 01 3528 https://library.oapen.org/handle/20.500.12657/40107 161 01 0960 https://library.oapen.org/handle/20.500.12657/40107 LF 187 01 3520 https://library.oapen.org/handle/20.500.12657/40107 213 01 0551 https://library.oapen.org/handle/20.500.12657/40107 230 01 0552 https://library.oapen.org/handle/20.500.12657/40107 283 01 3283 https://library.oapen.org/handle/20.500.12657/40107 293 01 3293 https://library.oapen.org/handle/20.500.12657/40107 LF 370 01 4370 https://library.oapen.org/handle/20.500.12657/40107 603 01 4603 https://library.oapen.org/handle/20.500.12657/40107 808 01 4808 Volltextzugang https://library.oapen.org/handle/20.500.12657/40107 2403 01 DE-LFER https://library.oapen.org/bitstream/id/b2319453-4f1d-4fa3-899c-e8d756eee652/9781138337992_oachapter7.pdf 31 01 0027 00 eBook GBV-OAPEN 22 01 0018 OLR-ZDB-94-OAL 23 01 0830 OLR-OAPEN 30 01 0104 GBV-OAPEN 34 01 3551 OLR-OAPEN 39 01 0547 GBV-OAPEN 39 01 0547 LF 40 01 0007 OLR-OAPEN 63 01 3401 E-Books LF GBV-OAPEN 65 01 0003 OLR-OAPEN 70 01 0089 OLR-OAPEN-OA 72 01 0035 OLR-OAPEN-OA 95 01 3095 OLR-OAL 110 01 3110 OLR-GBV-OAPEN 136 01 3526 OLR-OAPEN 147 01 3528 OLR-OAPEN 161 01 0960 OLR-OAPEN 213 01 0551 OLR-OAPEN 230 01 0552 OLR-OAPEN 283 01 3283 OLR-OAL 293 01 3293 OLR-OAPEN 370 01 4370 OLR-FREE 370 01 4370 olr-ebook GBV-OAPEN 603 01 4603 OLR-OAPEN 808 01 4808 OLR-OAPEN |
| spelling |
(DE-627)1836447507 (DE-599)KEP062186191 (OCoLC)1286318264 (OAPEN)40107 (EBP)062186191 DE-627 eng DE-627 rda eng MMG bicssc PSD bicssc PS bicssc MKG bicssc Carr, Anitra C. verfasserin aut Chapter 7 Vitamin C in Pneumonia and Sepsis [Erscheinungsort nicht ermittelbar] Taylor & Francis 2020 1 Online-Ressource (26 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Open Access Unrestricted online access star In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by members of the SLC23 family, SLC23A1/SVCT1 and SLC23A2/SVCT2. We present in silico models of these transporters that provide new insights into the structure of the SLC23 family. While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. In the future, SVCT1 and SVCT2 may furthermore prove useful as drug delivery systems, to enhance transport of novel pharmaceutical agents more efficiently across the intestinal epithelium and the blood-cerebrospinal fluid barrier Creative Commons https://creativecommons.org/licenses/by-nc-nd/4.0 cc English Pharmacology Molecular biology Biology, life sciences https://library.oapen.org/bitstream/id/b2319453-4f1d-4fa3-899c-e8d756eee652/9781138337992_oachapter7.pdf X:OAPEN Verlag OAPEN Library: download the publication kostenfrei https://library.oapen.org/handle/20.500.12657/40107 X:OAPEN Verlag OAPEN Library: description of the publication kostenfrei ZDB-94-OAL GBV_ILN_22 ISIL_DE-18 SYSFLAG_1 GBV_KXP GBV_ILN_23 ISIL_DE-830 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_34 ISIL_DE-18-302 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_95 ISIL_DE-542 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_187 ISIL_DE-Ki95 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_603 ISIL_DE-B1556 GBV_ILN_808 GBV_ILN_2403 ISIL_DE-LFER BO 22 01 0018 4280105642 OLR-ZDB-94-OAL OAPEN Library zu 01-03-23 23 01 0830 4280657645 OLR-OAPEN f z 01-03-23 30 01 0104 4281018018 GBV-OAPEN z 01-03-23 31 01 0027 4280300380 z 01-03-23 34 01 3551 4278855915 OLR-OAPEN zi002 01-03-23 39 01 0547 4281208836 GBV-OAPEN ke 01-03-23 40 01 0007 4279924414 OLR-OAPEN xsn 01-03-23 63 01 3401 4281589775 E-Books LF GBV-OAPEN z 01-03-23 65 01 0003 4281840885 OLR-OAPEN z 01-03-23 70 01 0089 4280478619 OLR-OAPEN-OA OAPEN Online Library Open Access eBook z 01-03-23 72 01 0035 4278676670 OLR-OAPEN-OA OAPEN Online Library Open Access eBook z 01-03-23 95 01 3095 4343204405 OLR-OAL Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 24-06-23 110 01 3110 4281393730 OLR-GBV-OAPEN Open Access z 01-03-23 136 01 3526 4279565481 OLR-OAPEN z 01-03-23 147 01 3528 4282038608 OLR-OAPEN frei verfügbar für Europa-Universität Flensburg, Hochschule Flensburg und Zentrale Hochschulbibliothek Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 01-03-23 161 01 0960 4278112211 OLR-OAPEN OAPEN Online Library Open Access eBook z 28-02-23 187 01 3520 4278497083 JSTOR Open Access eBook z 28-02-23 213 01 0551 4279211094 OLR-OAPEN OAPEN Online Library Open Access eBook z 01-03-23 230 01 0552 427938827X OLR-OAPEN OAPEN Online Library Open Access eBook z 01-03-23 283 01 3283 4279747180 OLR-OAL z 01-03-23 293 01 3293 4278291302 OLR-OAPEN OAPEN Online Library Open Access eBook z 28-02-23 370 01 4370 4279033668 OLR-FREE Kostenloser Zugriff z 01-03-23 603 01 4603 4277934315 OLR-OAPEN Bitte beachten Sie die Nutzungsbedingungen und Copyright-Bestimmungen des Verlages/Herausgebers. z 28-02-23 808 01 4808 4280836558 OLR-OAPEN OAPEN Library zg 01-03-23 2403 01 DE-LFER 430752179X 00 --%%-- --%%-- n --%%-- l01 11-04-23 22 01 0018 Volltextzugang https://library.oapen.org/handle/20.500.12657/40107 23 01 0830 https://library.oapen.org/handle/20.500.12657/40107 30 01 0104 Open Access https://library.oapen.org/handle/20.500.12657/40107 31 01 0027 eBook GBV-OAPEN https://library.oapen.org/handle/20.500.12657/40107 34 01 3551 OpenAccess https://library.oapen.org/handle/20.500.12657/40107 40 01 0007 Volltext, Open Access https://library.oapen.org/handle/20.500.12657/40107 63 01 3401 E-Book https://library.oapen.org/handle/20.500.12657/40107 65 01 0003 Open Access https://library.oapen.org/handle/20.500.12657/40107 65 01 0003 Dieser Titel ist Teil einer Datenbank http://www.bibliothek.uni-regensburg.de/dbinfo/detail.php?titel_id=10728&bib_id=ulb_hal 70 01 0089 https://library.oapen.org/handle/20.500.12657/40107 LF 72 01 0035 https://library.oapen.org/handle/20.500.12657/40107 95 01 3095 https://library.oapen.org/handle/20.500.12657/40107 110 01 3110 Open Access https://library.oapen.org/handle/20.500.12657/40107 136 01 3526 Open Access https://library.oapen.org/handle/20.500.12657/40107 147 01 3528 https://library.oapen.org/handle/20.500.12657/40107 161 01 0960 https://library.oapen.org/handle/20.500.12657/40107 LF 187 01 3520 https://library.oapen.org/handle/20.500.12657/40107 213 01 0551 https://library.oapen.org/handle/20.500.12657/40107 230 01 0552 https://library.oapen.org/handle/20.500.12657/40107 283 01 3283 https://library.oapen.org/handle/20.500.12657/40107 293 01 3293 https://library.oapen.org/handle/20.500.12657/40107 LF 370 01 4370 https://library.oapen.org/handle/20.500.12657/40107 603 01 4603 https://library.oapen.org/handle/20.500.12657/40107 808 01 4808 Volltextzugang https://library.oapen.org/handle/20.500.12657/40107 2403 01 DE-LFER https://library.oapen.org/bitstream/id/b2319453-4f1d-4fa3-899c-e8d756eee652/9781138337992_oachapter7.pdf 31 01 0027 00 eBook GBV-OAPEN 22 01 0018 OLR-ZDB-94-OAL 23 01 0830 OLR-OAPEN 30 01 0104 GBV-OAPEN 34 01 3551 OLR-OAPEN 39 01 0547 GBV-OAPEN 39 01 0547 LF 40 01 0007 OLR-OAPEN 63 01 3401 E-Books LF GBV-OAPEN 65 01 0003 OLR-OAPEN 70 01 0089 OLR-OAPEN-OA 72 01 0035 OLR-OAPEN-OA 95 01 3095 OLR-OAL 110 01 3110 OLR-GBV-OAPEN 136 01 3526 OLR-OAPEN 147 01 3528 OLR-OAPEN 161 01 0960 OLR-OAPEN 213 01 0551 OLR-OAPEN 230 01 0552 OLR-OAPEN 283 01 3283 OLR-OAL 293 01 3293 OLR-OAPEN 370 01 4370 OLR-FREE 370 01 4370 olr-ebook GBV-OAPEN 603 01 4603 OLR-OAPEN 808 01 4808 OLR-OAPEN |
| allfields_unstemmed |
(DE-627)1836447507 (DE-599)KEP062186191 (OCoLC)1286318264 (OAPEN)40107 (EBP)062186191 DE-627 eng DE-627 rda eng MMG bicssc PSD bicssc PS bicssc MKG bicssc Carr, Anitra C. verfasserin aut Chapter 7 Vitamin C in Pneumonia and Sepsis [Erscheinungsort nicht ermittelbar] Taylor & Francis 2020 1 Online-Ressource (26 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Open Access Unrestricted online access star In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by members of the SLC23 family, SLC23A1/SVCT1 and SLC23A2/SVCT2. We present in silico models of these transporters that provide new insights into the structure of the SLC23 family. While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. In the future, SVCT1 and SVCT2 may furthermore prove useful as drug delivery systems, to enhance transport of novel pharmaceutical agents more efficiently across the intestinal epithelium and the blood-cerebrospinal fluid barrier Creative Commons https://creativecommons.org/licenses/by-nc-nd/4.0 cc English Pharmacology Molecular biology Biology, life sciences https://library.oapen.org/bitstream/id/b2319453-4f1d-4fa3-899c-e8d756eee652/9781138337992_oachapter7.pdf X:OAPEN Verlag OAPEN Library: download the publication kostenfrei https://library.oapen.org/handle/20.500.12657/40107 X:OAPEN Verlag OAPEN Library: description of the publication kostenfrei ZDB-94-OAL GBV_ILN_22 ISIL_DE-18 SYSFLAG_1 GBV_KXP GBV_ILN_23 ISIL_DE-830 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_34 ISIL_DE-18-302 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_95 ISIL_DE-542 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_187 ISIL_DE-Ki95 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_603 ISIL_DE-B1556 GBV_ILN_808 GBV_ILN_2403 ISIL_DE-LFER BO 22 01 0018 4280105642 OLR-ZDB-94-OAL OAPEN Library zu 01-03-23 23 01 0830 4280657645 OLR-OAPEN f z 01-03-23 30 01 0104 4281018018 GBV-OAPEN z 01-03-23 31 01 0027 4280300380 z 01-03-23 34 01 3551 4278855915 OLR-OAPEN zi002 01-03-23 39 01 0547 4281208836 GBV-OAPEN ke 01-03-23 40 01 0007 4279924414 OLR-OAPEN xsn 01-03-23 63 01 3401 4281589775 E-Books LF GBV-OAPEN z 01-03-23 65 01 0003 4281840885 OLR-OAPEN z 01-03-23 70 01 0089 4280478619 OLR-OAPEN-OA OAPEN Online Library Open Access eBook z 01-03-23 72 01 0035 4278676670 OLR-OAPEN-OA OAPEN Online Library Open Access eBook z 01-03-23 95 01 3095 4343204405 OLR-OAL Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 24-06-23 110 01 3110 4281393730 OLR-GBV-OAPEN Open Access z 01-03-23 136 01 3526 4279565481 OLR-OAPEN z 01-03-23 147 01 3528 4282038608 OLR-OAPEN frei verfügbar für Europa-Universität Flensburg, Hochschule Flensburg und Zentrale Hochschulbibliothek Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. 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While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. 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<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000cam a22002652 4500</leader><controlfield tag="001">1836447507</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20241008150128.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">210309s2020 xx |||||o 00| ||eng c</controlfield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)1836447507</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)KEP062186191</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1286318264</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OAPEN)40107</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(EBP)062186191</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">eng</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="072" ind1=" " ind2="7"><subfield code="a">MMG</subfield><subfield code="2">bicssc</subfield></datafield><datafield tag="072" ind1=" " ind2="7"><subfield code="a">PSD</subfield><subfield code="2">bicssc</subfield></datafield><datafield tag="072" ind1=" " ind2="7"><subfield code="a">PS</subfield><subfield code="2">bicssc</subfield></datafield><datafield tag="072" ind1=" " ind2="7"><subfield code="a">MKG</subfield><subfield code="2">bicssc</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Carr, Anitra C.</subfield><subfield code="e">verfasserin</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">Chapter 7 Vitamin C in Pneumonia and Sepsis</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="a">[Erscheinungsort nicht ermittelbar]</subfield><subfield code="b">Taylor & Francis</subfield><subfield code="c">2020</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">1 Online-Ressource (26 p.)</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="506" ind1="0" ind2=" "><subfield code="a">Open Access</subfield><subfield code="f">Unrestricted online access</subfield><subfield code="2">star</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. 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In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by members of the SLC23 family, SLC23A1/SVCT1 and SLC23A2/SVCT2. We present in silico models of these transporters that provide new insights into the structure of the SLC23 family. While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. In the future, SVCT1 and SVCT2 may furthermore prove useful as drug delivery systems, to enhance transport of novel pharmaceutical agents more efficiently across the intestinal epithelium and the blood-cerebrospinal fluid barrier |
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In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by members of the SLC23 family, SLC23A1/SVCT1 and SLC23A2/SVCT2. We present in silico models of these transporters that provide new insights into the structure of the SLC23 family. While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. In the future, SVCT1 and SVCT2 may furthermore prove useful as drug delivery systems, to enhance transport of novel pharmaceutical agents more efficiently across the intestinal epithelium and the blood-cerebrospinal fluid barrier |
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In humans, ascorbic acid is an essential vitamin, anti-oxidant and co-factor of a variety of metal ion-dependent enzymatic reactions. In this review, the transport of L-ascorbic acid is described from food to target cells. Transport of ascorbic acid across the plasma membrane is facilitated by members of the SLC23 family, SLC23A1/SVCT1 and SLC23A2/SVCT2. We present in silico models of these transporters that provide new insights into the structure of the SLC23 family. While SVCT1 is mainly responsible for uptake of ascorbic acid from the intestine into the blood and for reabsorption in the kidney, the more broadly expressed transporter SVCT2 delivers ascorbic acid into tissues that are in high demand of the vitamin. The oxidized form of ascorbic acid, dehydroascorbic acid (DHA), is a substrate of the GLUT transporters belonging to the SLC2 family. They play important roles in ascorbic acid recycling, such as in the brain and in erythrocytes. Ascorbic acid serves as an essential co-factor of metal ion-dependent enzymes, keeping their metal ions in the reduced state. In addition, it serves as an effective antioxidant in cells with high metabolic activity such as neurons. Thus, it is not too surprising that changes in expression and function of the SVCTs have nutritional and pathological consequences such as during ageing, malnutrition and chronic alcohol abuse or in cancer, neurodegenerative diseases and chronic inflammation diseases. In the future, SVCT1 and SVCT2 may furthermore prove useful as drug delivery systems, to enhance transport of novel pharmaceutical agents more efficiently across the intestinal epithelium and the blood-cerebrospinal fluid barrier |
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7.166894 |