Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine
Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by sta...
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| Autor*in: |
Porcello, Alexandre [verfasserIn] Laurent, Alexis [verfasserIn] Hirt-Burri, Nathalie [verfasserIn] Abdel-Sayed, Philippe [verfasserIn] de Buys Roessingh, Anthony [verfasserIn] Raffoul, Wassim [verfasserIn] Jordan, Olivier [verfasserIn] Allémann, Eric [verfasserIn] Applegate, Lee Ann [verfasserIn] |
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| Format: |
E-Book |
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| Sprache: |
Unbestimmt |
| Erschienen: |
Erscheinungsort nicht ermittelbar: Taylor & Francis ; 2022 |
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| Rechteinformationen: |
Open Access Namensnennung 4.0 International ; CC BY 4.0 |
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| Schlagwörter: |
Pre-clinical medicine: basic sciences |
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| Umfang: |
1 Online-Ressource (31 p.) |
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| Links: | |
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| ISBN: |
978-0-367-72113-8 978-0-367-72116-9 |
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1877764590 |
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| 245 | 1 | 0 | |a Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine |
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| 520 | |a Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications | ||
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9780367721138 978-0-367-72113-8 9780367721169 978-0-367-72116-9 20.500.12854/122102 hdl (DE-627)1877764590 (DE-599)KEP100192580 (OCoLC)1418830426 (DOAB)122102 (EBP)100192580 DE-627 ger DE-627 rda und TBN bicssc TGM bicssc MF bicssc MBPM bicssc PN bicssc Porcello, Alexandre verfasserin aut Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine [Erscheinungsort nicht ermittelbar] Taylor & Francis 2022 1 Online-Ressource (31 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Open Access Unrestricted online access star Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications Namensnennung 4.0 International CC BY 4.0 cc https://creativecommons.org/licenses/by/4.0/ English Nanotechnology Materials science Pre-clinical medicine: basic sciences Medical administration & management Chemistry Laurent, Alexis verfasserin aut Hirt-Burri, Nathalie verfasserin aut Abdel-Sayed, Philippe verfasserin aut de Buys Roessingh, Anthony verfasserin aut Raffoul, Wassim verfasserin aut Jordan, Olivier verfasserin aut Allémann, Eric verfasserin aut Applegate, Lee Ann verfasserin aut https://directory.doabooks.org/handle/20.500.12854/122102 X:DOAB Verlag kostenfrei ZDB-94-OAB GBV_ILN_11 ISIL_DE-1a SYSFLAG_1 GBV_KXP GBV_ILN_20 ISIL_DE-84 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_60 ISIL_DE-705 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_91 ISIL_DE-HIL3 GBV_ILN_92 ISIL_DE-33 GBV_ILN_95 ISIL_DE-542 GBV_ILN_105 ISIL_DE-841 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_130 ISIL_DE-700 GBV_ILN_131 ISIL_DE-Va1 GBV_ILN_132 ISIL_DE-959 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_635 ISIL_DE-B2138 GBV_ILN_808 GBV_ILN_2011 ISIL_DE-16 GBV_ILN_2014 ISIL_DE-90 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2034 ISIL_DE-Rt2 GBV_ILN_2037 ISIL_DE-747 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2108 ISIL_DE-991 GBV_ILN_2403 ISIL_DE-LFER BO 11 01 0001 4470336726 00 5:LIZFREI --%%-- --%%-- --%%-- k 29-01-24 20 01 0084 4470925144 OLR-DOAB z 29-01-24 22 01 0018 4470504793 OLR-ZDB-94-OAB DOAB Directory of Open Access Books zu 29-01-24 23 01 0830 4470757004 olr-doab f z 29-01-24 24 01 0008 4471261363 OLR-doab z 29-01-24 30 01 0104 4471009176 OLR-OAB Open Access, Directory of Open Access Books (DOAB) z 29-01-24 31 01 0027 4470588822 OLR-DOAB z 29-01-24 39 01 0547 4471093258 OLR-ZDB-94-OAB ke 29-01-24 40 01 0007 4470420743 OLR-DOAB xsn 29-01-24 60 01 0705 4470000280 OPENAccess Vervielfältigungen (z.B. 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9780367721138 978-0-367-72113-8 9780367721169 978-0-367-72116-9 20.500.12854/122102 hdl (DE-627)1877764590 (DE-599)KEP100192580 (OCoLC)1418830426 (DOAB)122102 (EBP)100192580 DE-627 ger DE-627 rda und TBN bicssc TGM bicssc MF bicssc MBPM bicssc PN bicssc Porcello, Alexandre verfasserin aut Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine [Erscheinungsort nicht ermittelbar] Taylor & Francis 2022 1 Online-Ressource (31 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Open Access Unrestricted online access star Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications Namensnennung 4.0 International CC BY 4.0 cc https://creativecommons.org/licenses/by/4.0/ English Nanotechnology Materials science Pre-clinical medicine: basic sciences Medical administration & management Chemistry Laurent, Alexis verfasserin aut Hirt-Burri, Nathalie verfasserin aut Abdel-Sayed, Philippe verfasserin aut de Buys Roessingh, Anthony verfasserin aut Raffoul, Wassim verfasserin aut Jordan, Olivier verfasserin aut Allémann, Eric verfasserin aut Applegate, Lee Ann verfasserin aut https://directory.doabooks.org/handle/20.500.12854/122102 X:DOAB Verlag kostenfrei ZDB-94-OAB GBV_ILN_11 ISIL_DE-1a SYSFLAG_1 GBV_KXP GBV_ILN_20 ISIL_DE-84 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_60 ISIL_DE-705 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_91 ISIL_DE-HIL3 GBV_ILN_92 ISIL_DE-33 GBV_ILN_95 ISIL_DE-542 GBV_ILN_105 ISIL_DE-841 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_130 ISIL_DE-700 GBV_ILN_131 ISIL_DE-Va1 GBV_ILN_132 ISIL_DE-959 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_635 ISIL_DE-B2138 GBV_ILN_808 GBV_ILN_2011 ISIL_DE-16 GBV_ILN_2014 ISIL_DE-90 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2034 ISIL_DE-Rt2 GBV_ILN_2037 ISIL_DE-747 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2108 ISIL_DE-991 GBV_ILN_2403 ISIL_DE-LFER BO 11 01 0001 4470336726 00 5:LIZFREI --%%-- --%%-- --%%-- k 29-01-24 20 01 0084 4470925144 OLR-DOAB z 29-01-24 22 01 0018 4470504793 OLR-ZDB-94-OAB DOAB Directory of Open Access Books zu 29-01-24 23 01 0830 4470757004 olr-doab f z 29-01-24 24 01 0008 4471261363 OLR-doab z 29-01-24 30 01 0104 4471009176 OLR-OAB Open Access, Directory of Open Access Books (DOAB) z 29-01-24 31 01 0027 4470588822 OLR-DOAB z 29-01-24 39 01 0547 4471093258 OLR-ZDB-94-OAB ke 29-01-24 40 01 0007 4470420743 OLR-DOAB xsn 29-01-24 60 01 0705 4470000280 OPENAccess Vervielfältigungen (z.B. 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Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 11-04-24 808 01 4808 4470841102 OLR-DOAB DOAB Directory of Open Access Books zg 29-01-24 2011 01 DE-16 447424107X 00 --%%-- --%%-- --%%-- --%%-- l01 02-02-24 2014 01 DE-90 4474641450 00 --%%-- --%%-- --%%-- --%%-- l01 02-02-24 2018 01 DE-31 4474241088 00 --%%-- --%%-- --%%-- n Der Zugriff ist kostenfrei möglich. l01 02-02-24 2034 01 DE-Rt2 4474241096 00 --%%-- eBook n n frei zugänglich l01 02-02-24 2037 01 DE-747 447424110X 00 --%%-- eBook OAPEN Foundation OpenAccess --%%-- n Im Internet frei verfügbar l01 02-02-24 2050 01 DE-Zi4 4474641469 00 --%%-- --%%-- --%%-- n Elektronischer Volltext - Open Access l01 02-02-24 2108 01 DE-991 4474241118 00 --%%-- eBook DOAB --%%-- n Elektronischer Volltext - Campuslizenz l01 02-02-24 2403 01 DE-LFER 4474641477 00 --%%-- --%%-- n --%%-- l01 02-02-24 20 01 0084 https://directory.doabooks.org/handle/20.500.12854/122102 22 01 0018 Volltextzugang https://directory.doabooks.org/handle/20.500.12854/122102 23 01 0830 https://directory.doabooks.org/handle/20.500.12854/122102 24 01 0008 https://directory.doabooks.org/handle/20.500.12854/122102 30 01 0104 https://directory.doabooks.org/handle/20.500.12854/122102 31 01 0027 https://directory.doabooks.org/handle/20.500.12854/122102 40 01 0007 Volltext, Open Access https://directory.doabooks.org/handle/20.500.12854/122102 60 01 0705 https://directory.doabooks.org/handle/20.500.12854/122102 63 01 3401 E-Book https://directory.doabooks.org/handle/20.500.12854/122102 65 01 0003 Open Access https://directory.doabooks.org/handle/20.500.12854/122102 65 01 0003 Dieser Titel ist Teil einer Datenbank http://www.bibliothek.uni-regensburg.de/dbinfo/detail.php?titel_id=11367&bib_id=ulb_hal 70 01 0089 https://directory.doabooks.org/handle/20.500.12854/122102 72 01 0035 https://directory.doabooks.org/handle/20.500.12854/122102 90 01 3090 https://directory.doabooks.org/handle/20.500.12854/122102 91 01 3091 https://directory.doabooks.org/handle/20.500.12854/122102 92 01 0033 https://directory.doabooks.org/handle/20.500.12854/122102 95 01 3095 https://directory.doabooks.org/handle/20.500.12854/122102 105 01 0841 https://directory.doabooks.org/handle/20.500.12854/122102 110 01 3110 Open Access https://directory.doabooks.org/handle/20.500.12854/122102 130 01 0700 Open Access https://directory.doabooks.org/handle/20.500.12854/122102 131 01 3131 https://directory.doabooks.org/handle/20.500.12854/122102 132 01 0959 https://directory.doabooks.org/handle/20.500.12854/122102 136 01 3526 Open Access https://directory.doabooks.org/handle/20.500.12854/122102 147 01 3528 https://directory.doabooks.org/handle/20.500.12854/122102 161 01 0960 https://directory.doabooks.org/handle/20.500.12854/122102 LF 213 01 0551 https://directory.doabooks.org/handle/20.500.12854/122102 230 01 0552 https://directory.doabooks.org/handle/20.500.12854/122102 283 01 3283 https://directory.doabooks.org/handle/20.500.12854/122102 293 01 3293 https://directory.doabooks.org/handle/20.500.12854/122102 LF 370 01 4370 https://directory.doabooks.org/handle/20.500.12854/122102 635 01 3635 https://directory.doabooks.org/handle/20.500.12854/122102 808 01 4808 Volltextzugang https://directory.doabooks.org/handle/20.500.12854/122102 2011 01 DE-16 https://directory.doabooks.org/handle/20.500.12854/122102 2014 01 DE-90 Volltext frei verfügbar https://directory.doabooks.org/handle/20.500.12854/122102 2034 01 DE-Rt2 https://directory.doabooks.org/handle/20.500.12854/122102 2037 01 DE-747 https://directory.doabooks.org/handle/20.500.12854/122102 2050 01 DE-Zi4 https://directory.doabooks.org/handle/20.500.12854/122102 2108 01 DE-991 https://directory.doabooks.org/handle/20.500.12854/122102 2403 01 DE-LFER https://directory.doabooks.org/handle/20.500.12854/122102 31 01 0027 00 E-Book Open Access 132 01 0959 00 EBooks DOAB Open Access 20 01 0084 OLR-DOAB 22 01 0018 OLR-ZDB-94-OAB 23 01 0830 olr-doab 24 01 0008 OLR-doab 24 01 0008 olr-frei 30 01 0104 OLR-OAB 31 01 0027 OLR-DOAB 39 01 0547 OLR-ZDB-94-OAB 39 01 0547 LF 40 01 0007 OLR-DOAB 60 01 0705 OPENAccess 63 01 3401 E-Books LF GBV-DOAB 65 01 0003 OLR-DOAB 70 01 0089 OLR-DOAB-OA 72 01 0035 OLR-ZDB-94-OAB 90 01 3090 OLR-HILoapen 91 01 3091 OLR-DOAB 92 01 0033 OLR-Open Access DOAB 95 01 3095 OLR-OAB 105 01 0841 OLR-OAB 110 01 3110 OLR-DOAB 130 01 0700 OLR-DOAB 131 01 3131 OLR-OA-DOAB 132 01 0959 OLR-OAB 136 01 3526 OLR-DOAB 147 01 3528 OLR-DOAB 161 01 0960 OLR-DOAB 213 01 0551 OLR-DOAB 230 01 0552 OLR-DOAB 293 01 3293 OLR-DOAB 370 01 4370 OLR-FREE 370 01 4370 olr-ebook ZDB-94-OAB 635 01 3635 OLR-DOAB 808 01 4808 OLR-DOAB |
| allfields_unstemmed |
9780367721138 978-0-367-72113-8 9780367721169 978-0-367-72116-9 20.500.12854/122102 hdl (DE-627)1877764590 (DE-599)KEP100192580 (OCoLC)1418830426 (DOAB)122102 (EBP)100192580 DE-627 ger DE-627 rda und TBN bicssc TGM bicssc MF bicssc MBPM bicssc PN bicssc Porcello, Alexandre verfasserin aut Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine [Erscheinungsort nicht ermittelbar] Taylor & Francis 2022 1 Online-Ressource (31 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Open Access Unrestricted online access star Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications Namensnennung 4.0 International CC BY 4.0 cc https://creativecommons.org/licenses/by/4.0/ English Nanotechnology Materials science Pre-clinical medicine: basic sciences Medical administration & management Chemistry Laurent, Alexis verfasserin aut Hirt-Burri, Nathalie verfasserin aut Abdel-Sayed, Philippe verfasserin aut de Buys Roessingh, Anthony verfasserin aut Raffoul, Wassim verfasserin aut Jordan, Olivier verfasserin aut Allémann, Eric verfasserin aut Applegate, Lee Ann verfasserin aut https://directory.doabooks.org/handle/20.500.12854/122102 X:DOAB Verlag kostenfrei ZDB-94-OAB GBV_ILN_11 ISIL_DE-1a SYSFLAG_1 GBV_KXP GBV_ILN_20 ISIL_DE-84 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_60 ISIL_DE-705 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_91 ISIL_DE-HIL3 GBV_ILN_92 ISIL_DE-33 GBV_ILN_95 ISIL_DE-542 GBV_ILN_105 ISIL_DE-841 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_130 ISIL_DE-700 GBV_ILN_131 ISIL_DE-Va1 GBV_ILN_132 ISIL_DE-959 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_635 ISIL_DE-B2138 GBV_ILN_808 GBV_ILN_2011 ISIL_DE-16 GBV_ILN_2014 ISIL_DE-90 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2034 ISIL_DE-Rt2 GBV_ILN_2037 ISIL_DE-747 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2108 ISIL_DE-991 GBV_ILN_2403 ISIL_DE-LFER BO 11 01 0001 4470336726 00 5:LIZFREI --%%-- --%%-- --%%-- k 29-01-24 20 01 0084 4470925144 OLR-DOAB z 29-01-24 22 01 0018 4470504793 OLR-ZDB-94-OAB DOAB Directory of Open Access Books zu 29-01-24 23 01 0830 4470757004 olr-doab f z 29-01-24 24 01 0008 4471261363 OLR-doab z 29-01-24 30 01 0104 4471009176 OLR-OAB Open Access, Directory of Open Access Books (DOAB) z 29-01-24 31 01 0027 4470588822 OLR-DOAB z 29-01-24 39 01 0547 4471093258 OLR-ZDB-94-OAB ke 29-01-24 40 01 0007 4470420743 OLR-DOAB xsn 29-01-24 60 01 0705 4470000280 OPENAccess Vervielfältigungen (z.B. 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| allfieldsGer |
9780367721138 978-0-367-72113-8 9780367721169 978-0-367-72116-9 20.500.12854/122102 hdl (DE-627)1877764590 (DE-599)KEP100192580 (OCoLC)1418830426 (DOAB)122102 (EBP)100192580 DE-627 ger DE-627 rda und TBN bicssc TGM bicssc MF bicssc MBPM bicssc PN bicssc Porcello, Alexandre verfasserin aut Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine [Erscheinungsort nicht ermittelbar] Taylor & Francis 2022 1 Online-Ressource (31 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Open Access Unrestricted online access star Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications Namensnennung 4.0 International CC BY 4.0 cc https://creativecommons.org/licenses/by/4.0/ English Nanotechnology Materials science Pre-clinical medicine: basic sciences Medical administration & management Chemistry Laurent, Alexis verfasserin aut Hirt-Burri, Nathalie verfasserin aut Abdel-Sayed, Philippe verfasserin aut de Buys Roessingh, Anthony verfasserin aut Raffoul, Wassim verfasserin aut Jordan, Olivier verfasserin aut Allémann, Eric verfasserin aut Applegate, Lee Ann verfasserin aut https://directory.doabooks.org/handle/20.500.12854/122102 X:DOAB Verlag kostenfrei ZDB-94-OAB GBV_ILN_11 ISIL_DE-1a SYSFLAG_1 GBV_KXP GBV_ILN_20 ISIL_DE-84 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_60 ISIL_DE-705 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_91 ISIL_DE-HIL3 GBV_ILN_92 ISIL_DE-33 GBV_ILN_95 ISIL_DE-542 GBV_ILN_105 ISIL_DE-841 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_130 ISIL_DE-700 GBV_ILN_131 ISIL_DE-Va1 GBV_ILN_132 ISIL_DE-959 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_635 ISIL_DE-B2138 GBV_ILN_808 GBV_ILN_2011 ISIL_DE-16 GBV_ILN_2014 ISIL_DE-90 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2034 ISIL_DE-Rt2 GBV_ILN_2037 ISIL_DE-747 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2108 ISIL_DE-991 GBV_ILN_2403 ISIL_DE-LFER BO 11 01 0001 4470336726 00 5:LIZFREI --%%-- --%%-- --%%-- k 29-01-24 20 01 0084 4470925144 OLR-DOAB z 29-01-24 22 01 0018 4470504793 OLR-ZDB-94-OAB DOAB Directory of Open Access Books zu 29-01-24 23 01 0830 4470757004 olr-doab f z 29-01-24 24 01 0008 4471261363 OLR-doab z 29-01-24 30 01 0104 4471009176 OLR-OAB Open Access, Directory of Open Access Books (DOAB) z 29-01-24 31 01 0027 4470588822 OLR-DOAB z 29-01-24 39 01 0547 4471093258 OLR-ZDB-94-OAB ke 29-01-24 40 01 0007 4470420743 OLR-DOAB xsn 29-01-24 60 01 0705 4470000280 OPENAccess Vervielfältigungen (z.B. 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Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 11-04-24 808 01 4808 4470841102 OLR-DOAB DOAB Directory of Open Access Books zg 29-01-24 2011 01 DE-16 447424107X 00 --%%-- --%%-- --%%-- --%%-- l01 02-02-24 2014 01 DE-90 4474641450 00 --%%-- --%%-- --%%-- --%%-- l01 02-02-24 2018 01 DE-31 4474241088 00 --%%-- --%%-- --%%-- n Der Zugriff ist kostenfrei möglich. l01 02-02-24 2034 01 DE-Rt2 4474241096 00 --%%-- eBook n n frei zugänglich l01 02-02-24 2037 01 DE-747 447424110X 00 --%%-- eBook OAPEN Foundation OpenAccess --%%-- n Im Internet frei verfügbar l01 02-02-24 2050 01 DE-Zi4 4474641469 00 --%%-- --%%-- --%%-- n Elektronischer Volltext - Open Access l01 02-02-24 2108 01 DE-991 4474241118 00 --%%-- eBook DOAB --%%-- n Elektronischer Volltext - Campuslizenz l01 02-02-24 2403 01 DE-LFER 4474641477 00 --%%-- --%%-- n --%%-- l01 02-02-24 20 01 0084 https://directory.doabooks.org/handle/20.500.12854/122102 22 01 0018 Volltextzugang https://directory.doabooks.org/handle/20.500.12854/122102 23 01 0830 https://directory.doabooks.org/handle/20.500.12854/122102 24 01 0008 https://directory.doabooks.org/handle/20.500.12854/122102 30 01 0104 https://directory.doabooks.org/handle/20.500.12854/122102 31 01 0027 https://directory.doabooks.org/handle/20.500.12854/122102 40 01 0007 Volltext, Open Access https://directory.doabooks.org/handle/20.500.12854/122102 60 01 0705 https://directory.doabooks.org/handle/20.500.12854/122102 63 01 3401 E-Book https://directory.doabooks.org/handle/20.500.12854/122102 65 01 0003 Open Access https://directory.doabooks.org/handle/20.500.12854/122102 65 01 0003 Dieser Titel ist Teil einer Datenbank http://www.bibliothek.uni-regensburg.de/dbinfo/detail.php?titel_id=11367&bib_id=ulb_hal 70 01 0089 https://directory.doabooks.org/handle/20.500.12854/122102 72 01 0035 https://directory.doabooks.org/handle/20.500.12854/122102 90 01 3090 https://directory.doabooks.org/handle/20.500.12854/122102 91 01 3091 https://directory.doabooks.org/handle/20.500.12854/122102 92 01 0033 https://directory.doabooks.org/handle/20.500.12854/122102 95 01 3095 https://directory.doabooks.org/handle/20.500.12854/122102 105 01 0841 https://directory.doabooks.org/handle/20.500.12854/122102 110 01 3110 Open Access https://directory.doabooks.org/handle/20.500.12854/122102 130 01 0700 Open Access https://directory.doabooks.org/handle/20.500.12854/122102 131 01 3131 https://directory.doabooks.org/handle/20.500.12854/122102 132 01 0959 https://directory.doabooks.org/handle/20.500.12854/122102 136 01 3526 Open Access https://directory.doabooks.org/handle/20.500.12854/122102 147 01 3528 https://directory.doabooks.org/handle/20.500.12854/122102 161 01 0960 https://directory.doabooks.org/handle/20.500.12854/122102 LF 213 01 0551 https://directory.doabooks.org/handle/20.500.12854/122102 230 01 0552 https://directory.doabooks.org/handle/20.500.12854/122102 283 01 3283 https://directory.doabooks.org/handle/20.500.12854/122102 293 01 3293 https://directory.doabooks.org/handle/20.500.12854/122102 LF 370 01 4370 https://directory.doabooks.org/handle/20.500.12854/122102 635 01 3635 https://directory.doabooks.org/handle/20.500.12854/122102 808 01 4808 Volltextzugang https://directory.doabooks.org/handle/20.500.12854/122102 2011 01 DE-16 https://directory.doabooks.org/handle/20.500.12854/122102 2014 01 DE-90 Volltext frei verfügbar https://directory.doabooks.org/handle/20.500.12854/122102 2034 01 DE-Rt2 https://directory.doabooks.org/handle/20.500.12854/122102 2037 01 DE-747 https://directory.doabooks.org/handle/20.500.12854/122102 2050 01 DE-Zi4 https://directory.doabooks.org/handle/20.500.12854/122102 2108 01 DE-991 https://directory.doabooks.org/handle/20.500.12854/122102 2403 01 DE-LFER https://directory.doabooks.org/handle/20.500.12854/122102 31 01 0027 00 E-Book Open Access 132 01 0959 00 EBooks DOAB Open Access 20 01 0084 OLR-DOAB 22 01 0018 OLR-ZDB-94-OAB 23 01 0830 olr-doab 24 01 0008 OLR-doab 24 01 0008 olr-frei 30 01 0104 OLR-OAB 31 01 0027 OLR-DOAB 39 01 0547 OLR-ZDB-94-OAB 39 01 0547 LF 40 01 0007 OLR-DOAB 60 01 0705 OPENAccess 63 01 3401 E-Books LF GBV-DOAB 65 01 0003 OLR-DOAB 70 01 0089 OLR-DOAB-OA 72 01 0035 OLR-ZDB-94-OAB 90 01 3090 OLR-HILoapen 91 01 3091 OLR-DOAB 92 01 0033 OLR-Open Access DOAB 95 01 3095 OLR-OAB 105 01 0841 OLR-OAB 110 01 3110 OLR-DOAB 130 01 0700 OLR-DOAB 131 01 3131 OLR-OA-DOAB 132 01 0959 OLR-OAB 136 01 3526 OLR-DOAB 147 01 3528 OLR-DOAB 161 01 0960 OLR-DOAB 213 01 0551 OLR-DOAB 230 01 0552 OLR-DOAB 293 01 3293 OLR-DOAB 370 01 4370 OLR-FREE 370 01 4370 olr-ebook ZDB-94-OAB 635 01 3635 OLR-DOAB 808 01 4808 OLR-DOAB |
| allfieldsSound |
9780367721138 978-0-367-72113-8 9780367721169 978-0-367-72116-9 20.500.12854/122102 hdl (DE-627)1877764590 (DE-599)KEP100192580 (OCoLC)1418830426 (DOAB)122102 (EBP)100192580 DE-627 ger DE-627 rda und TBN bicssc TGM bicssc MF bicssc MBPM bicssc PN bicssc Porcello, Alexandre verfasserin aut Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine [Erscheinungsort nicht ermittelbar] Taylor & Francis 2022 1 Online-Ressource (31 p.) Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Open Access Unrestricted online access star Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications Namensnennung 4.0 International CC BY 4.0 cc https://creativecommons.org/licenses/by/4.0/ English Nanotechnology Materials science Pre-clinical medicine: basic sciences Medical administration & management Chemistry Laurent, Alexis verfasserin aut Hirt-Burri, Nathalie verfasserin aut Abdel-Sayed, Philippe verfasserin aut de Buys Roessingh, Anthony verfasserin aut Raffoul, Wassim verfasserin aut Jordan, Olivier verfasserin aut Allémann, Eric verfasserin aut Applegate, Lee Ann verfasserin aut https://directory.doabooks.org/handle/20.500.12854/122102 X:DOAB Verlag kostenfrei ZDB-94-OAB GBV_ILN_11 ISIL_DE-1a SYSFLAG_1 GBV_KXP GBV_ILN_20 ISIL_DE-84 GBV_ILN_22 ISIL_DE-18 GBV_ILN_23 ISIL_DE-830 GBV_ILN_24 ISIL_DE-8 GBV_ILN_30 ISIL_DE-104 GBV_ILN_31 ISIL_DE-27 GBV_ILN_39 ISIL_DE-547 GBV_ILN_40 ISIL_DE-7 GBV_ILN_60 ISIL_DE-705 GBV_ILN_63 ISIL_DE-Wim2 GBV_ILN_65 ISIL_DE-3 GBV_ILN_70 ISIL_DE-89 GBV_ILN_72 ISIL_DE-35 GBV_ILN_90 ISIL_DE-Hil2 GBV_ILN_91 ISIL_DE-HIL3 GBV_ILN_92 ISIL_DE-33 GBV_ILN_95 ISIL_DE-542 GBV_ILN_105 ISIL_DE-841 GBV_ILN_110 ISIL_DE-Luen4 GBV_ILN_130 ISIL_DE-700 GBV_ILN_131 ISIL_DE-Va1 GBV_ILN_132 ISIL_DE-959 GBV_ILN_136 ISIL_DE-Wis1 GBV_ILN_147 ISIL_DE-Fl3 GBV_ILN_161 ISIL_DE-960 GBV_ILN_213 ISIL_DE-551 GBV_ILN_230 ISIL_DE-552 GBV_ILN_283 ISIL_DE-Ha163 GBV_ILN_293 ISIL_DE-960-3 GBV_ILN_370 ISIL_DE-1373 GBV_ILN_635 ISIL_DE-B2138 GBV_ILN_808 GBV_ILN_2011 ISIL_DE-16 GBV_ILN_2014 ISIL_DE-90 GBV_ILN_2018 ISIL_DE-31 GBV_ILN_2034 ISIL_DE-Rt2 GBV_ILN_2037 ISIL_DE-747 GBV_ILN_2050 ISIL_DE-Zi4 GBV_ILN_2108 ISIL_DE-991 GBV_ILN_2403 ISIL_DE-LFER BO 11 01 0001 4470336726 00 5:LIZFREI --%%-- --%%-- --%%-- k 29-01-24 20 01 0084 4470925144 OLR-DOAB z 29-01-24 22 01 0018 4470504793 OLR-ZDB-94-OAB DOAB Directory of Open Access Books zu 29-01-24 23 01 0830 4470757004 olr-doab f z 29-01-24 24 01 0008 4471261363 OLR-doab z 29-01-24 30 01 0104 4471009176 OLR-OAB Open Access, Directory of Open Access Books (DOAB) z 29-01-24 31 01 0027 4470588822 OLR-DOAB z 29-01-24 39 01 0547 4471093258 OLR-ZDB-94-OAB ke 29-01-24 40 01 0007 4470420743 OLR-DOAB xsn 29-01-24 60 01 0705 4470000280 OPENAccess Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots. Nur für Angehörige der HSU: Volltextzugang von außerhalb des Campus mit Anmeldung über Shibboleth mit Ihrer Bibliothekskennung z 29-01-24 63 01 3401 4471513494 E-Books LF GBV-DOAB z 29-01-24 65 01 0003 4471597566 OLR-DOAB Nach dem deutschen Urheberrecht darf das Werk bzw. der Inhalt zum eigenen Gebrauch kostenfrei heruntergeladen, konsumiert, gespeichert oder ausgedruckt, nicht jedoch im Internet bereitgestellt oder an Außenstehende weitergegeben werden! z 29-01-24 70 01 0089 4470672874 OLR-DOAB-OA DOAB Directory of Open Access Books z 29-01-24 72 01 0035 4469446157 OLR-ZDB-94-OAB DOAB Directory of Open Access Books z 28-01-24 90 01 3090 4471177346 OLR-HILoapen z 29-01-24 91 01 3091 4469663786 OLR-DOAB DOAB Directory of Open Access Books z 29-01-24 92 01 0033 4470168491 OLR-Open Access DOAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. Das Ebook ist frei zugänglich. z 29-01-24 95 01 3095 4469574104 OLR-OAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 29-01-24 105 01 0841 4471765922 OLR-OAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. z 29-01-24 110 01 3110 4471345397 OLR-DOAB Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. 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tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-747</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-Zi4</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-991</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2403</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-LFER</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">BO</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">11</subfield><subfield code="1">01</subfield><subfield code="x">0001</subfield><subfield code="b">4470336726</subfield><subfield code="c">00</subfield><subfield code="f">5:LIZFREI</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">k</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">20</subfield><subfield code="1">01</subfield><subfield code="x">0084</subfield><subfield code="b">4470925144</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">22</subfield><subfield code="1">01</subfield><subfield code="x">0018</subfield><subfield code="b">4470504793</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">zu</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">23</subfield><subfield code="1">01</subfield><subfield code="x">0830</subfield><subfield code="b">4470757004</subfield><subfield code="h">olr-doab</subfield><subfield code="u">f</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">24</subfield><subfield code="1">01</subfield><subfield code="x">0008</subfield><subfield code="b">4471261363</subfield><subfield code="h">OLR-doab</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">30</subfield><subfield code="1">01</subfield><subfield code="x">0104</subfield><subfield code="b">4471009176</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Open Access, Directory of Open Access Books (DOAB)</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">31</subfield><subfield code="1">01</subfield><subfield code="x">0027</subfield><subfield code="b">4470588822</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">39</subfield><subfield code="1">01</subfield><subfield code="x">0547</subfield><subfield code="b">4471093258</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="y">ke</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">40</subfield><subfield code="1">01</subfield><subfield code="x">0007</subfield><subfield code="b">4470420743</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">xsn</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">60</subfield><subfield code="1">01</subfield><subfield code="x">0705</subfield><subfield code="b">4470000280</subfield><subfield code="h">OPENAccess</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots.</subfield><subfield code="k">Nur für Angehörige der HSU: Volltextzugang von außerhalb des Campus mit Anmeldung über Shibboleth mit Ihrer Bibliothekskennung</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">63</subfield><subfield code="1">01</subfield><subfield code="x">3401</subfield><subfield code="b">4471513494</subfield><subfield code="h">E-Books LF GBV-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">65</subfield><subfield code="1">01</subfield><subfield code="x">0003</subfield><subfield code="b">4471597566</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Nach dem deutschen Urheberrecht darf das Werk bzw. der Inhalt zum eigenen Gebrauch kostenfrei heruntergeladen, konsumiert, gespeichert oder ausgedruckt, nicht jedoch im Internet bereitgestellt oder an Außenstehende weitergegeben werden!</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">70</subfield><subfield code="1">01</subfield><subfield code="x">0089</subfield><subfield code="b">4470672874</subfield><subfield code="h">OLR-DOAB-OA</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">72</subfield><subfield code="1">01</subfield><subfield code="x">0035</subfield><subfield code="b">4469446157</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">28-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">90</subfield><subfield code="1">01</subfield><subfield code="x">3090</subfield><subfield code="b">4471177346</subfield><subfield code="h">OLR-HILoapen</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">91</subfield><subfield code="1">01</subfield><subfield code="x">3091</subfield><subfield code="b">4469663786</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">92</subfield><subfield code="1">01</subfield><subfield code="x">0033</subfield><subfield code="b">4470168491</subfield><subfield code="h">OLR-Open Access DOAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. Das Ebook ist frei zugänglich.</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">95</subfield><subfield code="1">01</subfield><subfield code="x">3095</subfield><subfield code="b">4469574104</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">105</subfield><subfield code="1">01</subfield><subfield code="x">0841</subfield><subfield code="b">4471765922</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">110</subfield><subfield code="1">01</subfield><subfield code="x">3110</subfield><subfield code="b">4471345397</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="k">Open Access</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">130</subfield><subfield code="1">01</subfield><subfield code="x">0700</subfield><subfield code="b">4471429469</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">131</subfield><subfield code="1">01</subfield><subfield code="x">3131</subfield><subfield code="b">4467099824</subfield><subfield code="h">OLR-OA-DOAB</subfield><subfield code="k">Bitte beachten Sie die Nutzungsbedingungen und Copyright-Bestimmungen des Verlages/Herausgebers.</subfield><subfield code="y">z</subfield><subfield code="z">24-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">132</subfield><subfield code="1">01</subfield><subfield code="x">0959</subfield><subfield code="b">4469313939</subfield><subfield code="h">OLR-OAB</subfield><subfield code="u">Open Access</subfield><subfield code="y">x</subfield><subfield code="z">28-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">136</subfield><subfield code="1">01</subfield><subfield code="x">3526</subfield><subfield code="b">4470084468</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">147</subfield><subfield code="1">01</subfield><subfield code="x">3528</subfield><subfield code="b">447168180X</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">frei verfügbar für Europa-Universität Flensburg, Hochschule Flensburg und Zentrale Hochschulbibliothek</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">161</subfield><subfield code="1">01</subfield><subfield code="x">0960</subfield><subfield code="b">4469133523</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">28-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">213</subfield><subfield code="1">01</subfield><subfield code="x">0551</subfield><subfield code="b">4469832189</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">230</subfield><subfield code="1">01</subfield><subfield code="x">0552</subfield><subfield code="b">4469916226</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">283</subfield><subfield code="1">01</subfield><subfield code="x">3283</subfield><subfield code="b">4470252638</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">293</subfield><subfield code="1">01</subfield><subfield code="x">3293</subfield><subfield code="b">4469220183</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">28-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">370</subfield><subfield code="1">01</subfield><subfield code="x">4370</subfield><subfield code="b">4469748080</subfield><subfield code="h">OLR-FREE</subfield><subfield code="k">Kostenloser Zugriff</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">635</subfield><subfield code="1">01</subfield><subfield code="x">3635</subfield><subfield code="b">4511009104</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Open Access. Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">11-04-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">808</subfield><subfield code="1">01</subfield><subfield code="x">4808</subfield><subfield code="b">4470841102</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">zg</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2011</subfield><subfield code="1">01</subfield><subfield code="x">DE-16</subfield><subfield code="b">447424107X</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2014</subfield><subfield code="1">01</subfield><subfield code="x">DE-90</subfield><subfield code="b">4474641450</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2018</subfield><subfield code="1">01</subfield><subfield code="x">DE-31</subfield><subfield code="b">4474241088</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Der Zugriff ist kostenfrei möglich.</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2034</subfield><subfield code="1">01</subfield><subfield code="x">DE-Rt2</subfield><subfield code="b">4474241096</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook</subfield><subfield code="e">n</subfield><subfield code="j">n</subfield><subfield code="k">frei zugänglich</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2037</subfield><subfield code="1">01</subfield><subfield code="x">DE-747</subfield><subfield code="b">447424110X</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook OAPEN Foundation OpenAccess</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Im Internet frei verfügbar</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2050</subfield><subfield code="1">01</subfield><subfield code="x">DE-Zi4</subfield><subfield code="b">4474641469</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - Open Access</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2108</subfield><subfield code="1">01</subfield><subfield code="x">DE-991</subfield><subfield code="b">4474241118</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook DOAB</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - Campuslizenz</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2403</subfield><subfield code="1">01</subfield><subfield code="x">DE-LFER</subfield><subfield code="b">4474641477</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">n</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">20</subfield><subfield code="1">01</subfield><subfield code="x">0084</subfield><subfield code="r">https://directory.doabooks.org/handle/20.500.12854/122102</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">22</subfield><subfield code="1">01</subfield><subfield code="x">0018</subfield><subfield code="y">Volltextzugang</subfield><subfield code="r">https://directory.doabooks.org/handle/20.500.12854/122102</subfield></datafield><datafield tag="981" ind1=" " ind2=" "><subfield code="2">23</subfield><subfield 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Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine |
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chapter 8 hyaluronan-based hydrogels as functional vectors for standardised therapeutics in tissue engineering and regenerative medicine |
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Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine |
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Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications |
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Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications |
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Hyaluronan-based hydrogels are optimal candidates when developing novel combined advanced therapy medicinal products (cATMP), tissue engineering products (TEP), and medical devices. The key physico-chemical properties of hydrogels may hinder, mediate, or stimulate therapeutic potentials borne by standardised cellular substrates in regenerative medicine. Parallel to delivery system or scaffold development, hydrogel functionalisation may be advantageous in specific musculoskeletal interventions or topical applications (e.g. viscosupplementation, soft tissue volumetric supplementation, rehabilitation topical preparations). Optimised combination product developmental workflows enable pragmatic regulatory classification of cell-based preparations. Such aspects will be discussed, as well as sustainable transposition to industrialised production settings. Hyaluronan benefits from extensive hindsight in numerous human and veterinary applications, providing a highly versatile backbone for quasi-infinite structural modification and physico-chemical property modulation. This chapter provides an overview of critical product design considerations and possible therapeutic applications of versatile hyaluronan-based preparations intended for cell therapy delivery, combined with optimised autologous or allogeneic therapeutic cell sources (e.g. platelet-rich plasma, stem cells, banked primary foetal progenitors). Particular focus was set on specific parameters directly impacting product potential in terms of clinical translation and effectiveness for topical wound healing or sub-critical volumetric defect correction and repair stimulation in musculoskeletal regenerative medicine applications |
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Chapter 8 Hyaluronan-Based Hydrogels as Functional Vectors for Standardised Therapeutics in Tissue Engineering and Regenerative Medicine |
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ind2=" "><subfield code="a">ISIL_DE-B2138</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_808</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2011</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-16</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2014</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-90</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2018</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-31</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2034</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-Rt2</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2037</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-747</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2050</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-Zi4</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2108</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-991</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">GBV_ILN_2403</subfield></datafield><datafield tag="912" ind1=" " ind2=" "><subfield code="a">ISIL_DE-LFER</subfield></datafield><datafield tag="951" ind1=" " ind2=" "><subfield code="a">BO</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">11</subfield><subfield code="1">01</subfield><subfield code="x">0001</subfield><subfield code="b">4470336726</subfield><subfield code="c">00</subfield><subfield code="f">5:LIZFREI</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">k</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">20</subfield><subfield code="1">01</subfield><subfield code="x">0084</subfield><subfield code="b">4470925144</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">22</subfield><subfield code="1">01</subfield><subfield code="x">0018</subfield><subfield code="b">4470504793</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">zu</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">23</subfield><subfield code="1">01</subfield><subfield code="x">0830</subfield><subfield code="b">4470757004</subfield><subfield code="h">olr-doab</subfield><subfield code="u">f</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">24</subfield><subfield code="1">01</subfield><subfield code="x">0008</subfield><subfield code="b">4471261363</subfield><subfield code="h">OLR-doab</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">30</subfield><subfield code="1">01</subfield><subfield code="x">0104</subfield><subfield code="b">4471009176</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Open Access, Directory of Open Access Books (DOAB)</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">31</subfield><subfield code="1">01</subfield><subfield code="x">0027</subfield><subfield code="b">4470588822</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">39</subfield><subfield code="1">01</subfield><subfield code="x">0547</subfield><subfield code="b">4471093258</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="y">ke</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">40</subfield><subfield code="1">01</subfield><subfield code="x">0007</subfield><subfield code="b">4470420743</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">xsn</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">60</subfield><subfield code="1">01</subfield><subfield code="x">0705</subfield><subfield code="b">4470000280</subfield><subfield code="h">OPENAccess</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Keine Weitergabe an Dritte. Kein systematisches Downloaden durch Robots.</subfield><subfield code="k">Nur für Angehörige der HSU: Volltextzugang von außerhalb des Campus mit Anmeldung über Shibboleth mit Ihrer Bibliothekskennung</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">63</subfield><subfield code="1">01</subfield><subfield code="x">3401</subfield><subfield code="b">4471513494</subfield><subfield code="h">E-Books LF GBV-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">65</subfield><subfield code="1">01</subfield><subfield code="x">0003</subfield><subfield code="b">4471597566</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Nach dem deutschen Urheberrecht darf das Werk bzw. der Inhalt zum eigenen Gebrauch kostenfrei heruntergeladen, konsumiert, gespeichert oder ausgedruckt, nicht jedoch im Internet bereitgestellt oder an Außenstehende weitergegeben werden!</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">70</subfield><subfield code="1">01</subfield><subfield code="x">0089</subfield><subfield code="b">4470672874</subfield><subfield code="h">OLR-DOAB-OA</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">72</subfield><subfield code="1">01</subfield><subfield code="x">0035</subfield><subfield code="b">4469446157</subfield><subfield code="h">OLR-ZDB-94-OAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">28-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">90</subfield><subfield code="1">01</subfield><subfield code="x">3090</subfield><subfield code="b">4471177346</subfield><subfield code="h">OLR-HILoapen</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">91</subfield><subfield code="1">01</subfield><subfield code="x">3091</subfield><subfield code="b">4469663786</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">92</subfield><subfield code="1">01</subfield><subfield code="x">0033</subfield><subfield code="b">4470168491</subfield><subfield code="h">OLR-Open Access DOAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt. Das Ebook ist frei zugänglich.</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">95</subfield><subfield code="1">01</subfield><subfield code="x">3095</subfield><subfield code="b">4469574104</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">105</subfield><subfield code="1">01</subfield><subfield code="x">0841</subfield><subfield code="b">4471765922</subfield><subfield code="h">OLR-OAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">110</subfield><subfield code="1">01</subfield><subfield code="x">3110</subfield><subfield code="b">4471345397</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="k">Open Access</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">130</subfield><subfield code="1">01</subfield><subfield code="x">0700</subfield><subfield code="b">4471429469</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">131</subfield><subfield code="1">01</subfield><subfield code="x">3131</subfield><subfield code="b">4467099824</subfield><subfield code="h">OLR-OA-DOAB</subfield><subfield code="k">Bitte beachten Sie die Nutzungsbedingungen und Copyright-Bestimmungen des Verlages/Herausgebers.</subfield><subfield code="y">z</subfield><subfield code="z">24-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">132</subfield><subfield code="1">01</subfield><subfield code="x">0959</subfield><subfield code="b">4469313939</subfield><subfield code="h">OLR-OAB</subfield><subfield code="u">Open Access</subfield><subfield code="y">x</subfield><subfield code="z">28-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">136</subfield><subfield code="1">01</subfield><subfield code="x">3526</subfield><subfield code="b">4470084468</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">147</subfield><subfield code="1">01</subfield><subfield code="x">3528</subfield><subfield code="b">447168180X</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">frei verfügbar für Europa-Universität Flensburg, Hochschule Flensburg und Zentrale Hochschulbibliothek</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">161</subfield><subfield code="1">01</subfield><subfield code="x">0960</subfield><subfield code="b">4469133523</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">28-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">213</subfield><subfield code="1">01</subfield><subfield code="x">0551</subfield><subfield code="b">4469832189</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">230</subfield><subfield code="1">01</subfield><subfield code="x">0552</subfield><subfield code="b">4469916226</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">283</subfield><subfield code="1">01</subfield><subfield code="x">3283</subfield><subfield code="b">4470252638</subfield><subfield code="k">Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">293</subfield><subfield code="1">01</subfield><subfield code="x">3293</subfield><subfield code="b">4469220183</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">z</subfield><subfield code="z">28-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">370</subfield><subfield code="1">01</subfield><subfield code="x">4370</subfield><subfield code="b">4469748080</subfield><subfield code="h">OLR-FREE</subfield><subfield code="k">Kostenloser Zugriff</subfield><subfield code="y">z</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">635</subfield><subfield code="1">01</subfield><subfield code="x">3635</subfield><subfield code="b">4511009104</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">Open Access. Vervielfältigungen (z.B. Kopien, Downloads) sind nur von einzelnen Kapiteln oder Seiten und nur zum eigenen wissenschaftlichen Gebrauch erlaubt. Die Weitergabe an Dritte sowie systematisches Downloaden sind untersagt.</subfield><subfield code="y">z</subfield><subfield code="z">11-04-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">808</subfield><subfield code="1">01</subfield><subfield code="x">4808</subfield><subfield code="b">4470841102</subfield><subfield code="h">OLR-DOAB</subfield><subfield code="k">DOAB Directory of Open Access Books</subfield><subfield code="y">zg</subfield><subfield code="z">29-01-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2011</subfield><subfield code="1">01</subfield><subfield code="x">DE-16</subfield><subfield code="b">447424107X</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2014</subfield><subfield code="1">01</subfield><subfield code="x">DE-90</subfield><subfield code="b">4474641450</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">--%%--</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2018</subfield><subfield code="1">01</subfield><subfield code="x">DE-31</subfield><subfield code="b">4474241088</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Der Zugriff ist kostenfrei möglich.</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2034</subfield><subfield code="1">01</subfield><subfield code="x">DE-Rt2</subfield><subfield code="b">4474241096</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook</subfield><subfield code="e">n</subfield><subfield code="j">n</subfield><subfield code="k">frei zugänglich</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2037</subfield><subfield code="1">01</subfield><subfield code="x">DE-747</subfield><subfield code="b">447424110X</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook OAPEN Foundation OpenAccess</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Im Internet frei verfügbar</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2050</subfield><subfield code="1">01</subfield><subfield code="x">DE-Zi4</subfield><subfield code="b">4474641469</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">--%%--</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - Open Access</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield code="2">2108</subfield><subfield code="1">01</subfield><subfield code="x">DE-991</subfield><subfield code="b">4474241118</subfield><subfield code="c">00</subfield><subfield code="f">--%%--</subfield><subfield code="d">eBook DOAB</subfield><subfield code="e">--%%--</subfield><subfield code="j">n</subfield><subfield code="k">Elektronischer Volltext - Campuslizenz</subfield><subfield code="y">l01</subfield><subfield code="z">02-02-24</subfield></datafield><datafield tag="980" ind1=" " ind2=" "><subfield 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