Therapeutic Value of Hyperthermic Intraperitoneal Chemotherapy on Non-radical Appendiceal Low-grade Pseudomyxoma Peritonei

Objective To explore the application value of hyperthermic intraperitoneal chemotherapy(HIPEC) on non-radical appendiceal low-grade pseudomyxoma peritonei(PMP). Methods We retrospectively analyzed the clinical data of 300 patients with non-radical appendiceal-origin low-grade PMP, and the prognostic...
Ausführliche Beschreibung

Objective To explore the application value of hyperthermic intraperitoneal chemotherapy(HIPEC) on non-radical appendiceal low-grade pseudomyxoma peritonei(PMP). Methods We retrospectively analyzed the clinical data of 300 patients with non-radical appendiceal-origin low-grade PMP, and the prognostic factors and therapeutic value of HIPEC. Results The 10-year overall survival(OS) of 237 cases treated with HIPEC was significantly higher than that without HIPEC (52% vs. 26%, P < 0.001); the 10-year OS of the patients treated with intra- and post-operative HIPEC was also significantly higher than that with intraoperative HIPEC (57% vs. 44%, P=0.004). Univariate analysis showed that HIPEC, radical degree, PCI < 30 before tumor reduction, PCI < 30 after tumor reduction and CA199 abnormality were prognostic factors. Multivariate analysis showed that without HIPEC and CA125 abnormality were independent risk factors for poor prognosis. Conclusion For appendiceal low-grade PMP patients who cannot achieve complete cytoreduction, palliative maximal cytoreductive combined with HIPEC could significantly improve the long-term prognosis. Ausführliche Beschreibung