Synthesis, characterization, and anticancer activity of mononuclear Schiff-base metal complexes

In this study, 9 transition metal complexes, namely, [M(HL n)2]·0.5(H2O) (1, M = Ni, n = i; 2, M = Zn, n = i; 3, M = Ni, n = ii; 7, M = Zn, n = iv); [M(HL n)2]·0.25(H2O) (4, M = Zn, n = ii; 8, M = Ni, n = v); [Zn(HLiii )2]·DMF·H2O...
Ausführliche Beschreibung

In this study, 9 transition metal complexes, namely, [M(HL n)2]·0.5(H2O) (1, M = Ni, n = i; 2, M = Zn, n = i; 3, M = Ni, n = ii; 7, M = Zn, n = iv); [M(HL n)2]·0.25(H2O) (4, M = Zn, n = ii; 8, M = Ni, n = v); [Zn(HLiii )2]·DMF·H2O (5); [Ni(HL iv)2]·0.5(C2H5OH) (6), Zn(HL v)2 (9) (H2Li  = (E)-4‑chloro-2-((2- (6-chloropyridin-2-yl)hydrazineylidene)methyl)phenol; H2Lii  = (E)-4‑bromo-2-((2-(6-chloropyridin- 2-yl)hydrazineylidene)methyl)phenol; H2Liii  = (E)-2,4-dibromo-6-((2-(6-chloropyridin-2-yl) hydrazineylidene)methyl)phenol; H2Liv  = (E)-2-((2-(6-bromopyridin-2-yl)hydrazineylidene)methyl)- 4-chlorophenol; H2Lv  = (E)-4‑bromo-2-((2-(6-bromopyridin-2-yl) hydrazineylidene)methyl)phenol; DMF = N,N-dimethylformamide) were synthesized and characterized by Elemental analysis (EA), Infrared spectroscopy (IR), Single-crystal X-ray diffraction (SC-XRD) and Hirshfeld surface analyses. Moreover, we also investigated the anticancer effects of these 9 structures by standard MTT assay. Anticancer activity studies have shown that these metal complexes play a role in inhibiting the growth of cancer cells. Ausführliche Beschreibung