Alterations in eicosanoid levels during U937 bcl-xL tumour growth suppression and recovery in NU/NU mice in vivo—Involvement of phospholipase A2

• We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping...
Ausführliche Beschreibung

• We report for the first time that the HX Analog, PBT-4, blocks AA release in vivo. • PBT-4, blocks growth of leukaemic U937 derived tumours in vivo. • During tumour growth blockade, AA release and 12-HETE formation was inhibited – other eicosanoids were blocked as well. • 2–3 weeks after stopping PBT-4 treatment, AA and 12-HETE levels increased associated with tumour growth. • This data shows that the anti-cancer effects of PBT may be through inhibition of PLAse A2 in this cancer model in vivo. Ausführliche Beschreibung