Apoptosis signal-regulating kinase-1 aggravates ROS-mediated striatal degeneration in 3-nitropropionic acid-infused mice

• Systemic infusion of 3-NP increased ROS and led striatal cell loss. • ASK1 down-regulation decreased striatal cell death without scavenging ROS. • Adding ASK1protein to SOD tg aggravated striatal degeneration. • ASK1 activation induced by ROS is an important step of the 3-NP pathophysiology....
Ausführliche Beschreibung

• Systemic infusion of 3-NP increased ROS and led striatal cell loss. • ASK1 down-regulation decreased striatal cell death without scavenging ROS. • Adding ASK1protein to SOD tg aggravated striatal degeneration. • ASK1 activation induced by ROS is an important step of the 3-NP pathophysiology. Ausführliche Beschreibung