Toxicological effect of single contaminants and contaminant mixtures associated with plant ingredients in novel salmon feeds

• Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on...
Ausführliche Beschreibung

• Atlantic salmon primary hepatocytes were used to screen for interaction effects caused by PAHs and pesticides. • Lipidomic and transcriptomic profiling suggested perturbation of lipid metabolism and endocrine disruption. • The pesticides gave the strongest responses, despite having less effect on cell viability than the PAHs. • The primary mixture effect was additive. • At high concentrations, the pesticides acted synergistic by decreasing cell viability and down-regulating CYP3A and FABP4. Ausführliche Beschreibung