Brain serotonin 4 receptor binding is associated with the cortisol awakening response

• We performed a cross-sectional study to evaluate the association between brain serotonin 4 receptor binding and HPA-axis dynamics in healthy individuals. • We demonstrate a robust negative association between brain serotonin 4 receptor binding and the cortisol awakening response. • Our results rei...
Ausführliche Beschreibung

• We performed a cross-sectional study to evaluate the association between brain serotonin 4 receptor binding and HPA-axis dynamics in healthy individuals. • We demonstrate a robust negative association between brain serotonin 4 receptor binding and the cortisol awakening response. • Our results reinforce an association between serotonin signalling and HPA-axis function in the human brain. • We suggest that serotonergic neurotransmission support HPA-axis dynamics in healthy individuals. Ausführliche Beschreibung