Persistent cystic fibrosis isolate Pseudomonas aeruginosa strain RP73 exhibits an under-acylated LPS structure responsible of its low inflammatory activity

Highlights • Elucidation of the cystic fibrosis chronic strain P. aeruginosa RP73 LOS structure. • Analyses show a core oligosaccharide typically present in P. aeruginosa strains. • P. aeruginosa RP73 lipid A is different from previously elucidated lipid A forms. • P. aeruginosa RP73 LOS has a low i...
Ausführliche Beschreibung

Highlights • Elucidation of the cystic fibrosis chronic strain P. aeruginosa RP73 LOS structure. • Analyses show a core oligosaccharide typically present in P. aeruginosa strains. • P. aeruginosa RP73 lipid A is different from previously elucidated lipid A forms. • P. aeruginosa RP73 LOS has a low inflammatory capacity. • We propose that LPS lipid A under-acylation is a hallmark of chronic infections. Ausführliche Beschreibung