n-TiO2 and CdCl2 co-exposure to titanium dioxide nanoparticles and cadmium: Genomic, DNA and chromosomal damage evaluation in the marine fish European sea bass (Dicentrarchus labrax)

• European sea bass was exposed to CdCl2 and n-TiO2 alone and in combination. • Genotoxicity was evaluated by RAPD-assay, comet assay and cytome assay. • CdCl2 induced DNA primary damage but not chromosomal damage. • n-TiO2 induced chromosomal damage but not DNA primary damage. • Co-exposure effects...
Ausführliche Beschreibung

• European sea bass was exposed to CdCl2 and n-TiO2 alone and in combination. • Genotoxicity was evaluated by RAPD-assay, comet assay and cytome assay. • CdCl2 induced DNA primary damage but not chromosomal damage. • n-TiO2 induced chromosomal damage but not DNA primary damage. • Co-exposure effects depend on the biomarker used. Ausführliche Beschreibung