Development of an in vitro model of human bronchial epithelial barrier to study nanoparticle translocation

• Calu-3 cells was the most relevant respiratory model for studying NP translocation. • A549 and NCI-H292 cells grown on Transwell filters did not form a tight epithelium. • NP translocated respectively at 3%, 9% and 35% across Calu-3, NCI-H292 and A549 cells. • The TEER was not modified regardless...
Ausführliche Beschreibung

• Calu-3 cells was the most relevant respiratory model for studying NP translocation. • A549 and NCI-H292 cells grown on Transwell filters did not form a tight epithelium. • NP translocated respectively at 3%, 9% and 35% across Calu-3, NCI-H292 and A549 cells. • The TEER was not modified regardless the cell line used after 24h of treatment. Ausführliche Beschreibung