Association study involving polymorphisms in IL-6, IL-1RA, and CTLA4 genes and rheumatic heart disease in New Zealand population of Māori and Pacific ancestry

• RF incidence is among the world’s highest amid NZ individuals of Polynesian ancestry. • We found IL-6 promoter rs1800797 might influence susceptibility for RHD in this population. • IL1RN rs447713 may influence the severity of carditis in this population. • These finding may help guiding future cl...
Ausführliche Beschreibung

• RF incidence is among the world’s highest amid NZ individuals of Polynesian ancestry. • We found IL-6 promoter rs1800797 might influence susceptibility for RHD in this population. • IL1RN rs447713 may influence the severity of carditis in this population. • These finding may help guiding future clinical trials. Ausführliche Beschreibung