Toona sinensis (aqueous leaf extracts) induces apoptosis through the generation of ROS and activation of intrinsic apoptotic pathways in human renal carcinoma cells

• T. sinensis induces apoptosis in renal carcinoma cells. • ROS generation is involved in T. sinensis-induced apoptosis. • T. sinensis causes mitochondria-dependent caspase-3, -7, and -9 activation. • T. sinensis induces apoptosis by inhibiting anti-apoptotic proteins. • Quercetin, gallic acid, and...
Ausführliche Beschreibung

• T. sinensis induces apoptosis in renal carcinoma cells. • ROS generation is involved in T. sinensis-induced apoptosis. • T. sinensis causes mitochondria-dependent caspase-3, -7, and -9 activation. • T. sinensis induces apoptosis by inhibiting anti-apoptotic proteins. • Quercetin, gallic acid, and tannic acid also inhibit RCC cell growth. Ausführliche Beschreibung