Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions

• Tyrosol and resveratrol inhibit PAF production induced by IL-1β in U-937 cells. • Tyrosol is more potent inhibitor than resveratrol. • PAF levels after compounds incubation are mainly regulated by biosynthetic enzymes. • Acetylation seems to retain inhibitory effect of tyrosol. • Specific resverat...
Ausführliche Beschreibung

• Tyrosol and resveratrol inhibit PAF production induced by IL-1β in U-937 cells. • Tyrosol is more potent inhibitor than resveratrol. • PAF levels after compounds incubation are mainly regulated by biosynthetic enzymes. • Acetylation seems to retain inhibitory effect of tyrosol. • Specific resveratrol acetylated derivatives exhibited dual action. Ausführliche Beschreibung