Genome rearrangement of influenza virus for anti-viral drug screening

• The viral genome of A/California/04/2009 (H1N1) can be rearranged to express GFP or Gaussia luciferase (GLuc). • Amantadine sensitive and resistant GLuc expressing variants were evaluated for anti-viral screening in the presence of amantadine. • Viral expressed luciferase was shown to be suitable...
Ausführliche Beschreibung

• The viral genome of A/California/04/2009 (H1N1) can be rearranged to express GFP or Gaussia luciferase (GLuc). • Amantadine sensitive and resistant GLuc expressing variants were evaluated for anti-viral screening in the presence of amantadine. • Viral expressed luciferase was shown to be suitable for in vitro and in vivo anti-viral screening. Ausführliche Beschreibung