Comparison of bolus injection and constant infusion methods for measuring muscle protein fractional synthesis rate in humans

The use of stable isotope tracer techniques to measure muscle protein fractional synthesis rate (FSR) has been well established and widely used. The most common method that has been utilized so far is a primed constant infusion (CI) method, which requires 3–4h of tracer infusion. However, recently o...
Ausführliche Beschreibung

The use of stable isotope tracer techniques to measure muscle protein fractional synthesis rate (FSR) has been well established and widely used. The most common method that has been utilized so far is a primed constant infusion (CI) method, which requires 3–4h of tracer infusion. However, recently our group has developed a bolus injection (BI) method, which requires an injection of bolus of tracer and can be completed within 1h. In this study, we compared calf (gastrocnemius) muscle protein FSR measured using these two different methods — CI and BI. Ausführliche Beschreibung