Human hydroxylated metabolites of BDE-47 and BDE-99 are glucuronidated and sulfated in vitro

• This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the...
Ausführliche Beschreibung

• This is the first study investigating human Phase-II metabolism of PBDEs in vitro. • All hydroxylated metabolites of BDE-47 and BDE-99 were glucuronidated and sulfated. • 2,4-DBP-Gluc and 5-Gluc-BDE-47 are the major glucuronidated metabolites of BDE-47. • 2,4,5-TBP-Gluc and 6′-Gluc-BDE-99 are the major glucuronidated metabolites of BDE-99. • 4-Sulf-BDE-42 and 3-Sulf-BDE-47 are the major sulfated metabolites of BDE-47. • 3′-Sulf-BDE-99 and 5′-Sulf-BDE-99 are the major sulfated metabolites of BDE-99. Ausführliche Beschreibung