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SILA-421 activity in vitro against rifampicin-susceptible and rifampicin-resistant Mycobacterium tuberculosis, and in vivo in a murine tuberculosis model
• SILA-421 has bactericidal activity towards Mycobacterium tuberculosis strains of the Beijing genotype. • SILA-421 enhanced the mycobacterial killing capacity of isoniazid and rifampicin. • SILA-421 prevented the emergence of isoniazid resistance.