Cytoreductive surgery for head and neck squamous cell carcinoma in the new age of immunotherapy

• Patients who develop local-regional disease progression in conjunction with distant metastasis have few good palliative options available to achieve local tumor control and/or relieve symptoms. • The goal of cytoreductive surgery is to minimize tumor-induced immune suppression by reducing the numb...
Ausführliche Beschreibung

• Patients who develop local-regional disease progression in conjunction with distant metastasis have few good palliative options available to achieve local tumor control and/or relieve symptoms. • The goal of cytoreductive surgery is to minimize tumor-induced immune suppression by reducing the number of cancer cells via resection of primary tumor or metastatic deposits, to palliate symptoms, and prevent complications. • We hypothesize that surgical resection can be combined with immunotherapy to induce an effective immune response and overcome immunosuppression in the tumor microenvironment. Ausführliche Beschreibung