Mixed ligand complexes of the novel nanoferrocene based Schiff base ligand (HL): Synthesis, spectroscopic characterization, MOE studies and antimicrobial/anticancer activities

A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully cha...
Ausführliche Beschreibung

A series of transition metal complexes of Cr(III), Mn(II), Fe(III), Co(II), Ni(II), Cu(II), Zn(II) and Cd(II) with (Z)- 4-(1-((2-carboxycyclohexa-2,4-dien-1-yl)imino)-ethyl)[bis(η 5 -cyclopenta-1,3-dien-1-yl)]iron (HL) mixed with 1,10-phenanthroline (Phen.) have been synthesized and successfully characterized using various spectrochemical techniques: elemental analyses, molar conductance, IR, 1H NMR, mass spectroscopy, SEM, thermal analysis (TG/DTG), MOE, biological and anticancer activities. The molecular structures of the HL ligand and its Fe(III) complex were determined by SEM studies. HL ligand acts as a bidentate ligand and coordinates to metal ion center via deprotonated carboxylate oxygen atom and azomethine nitrogen. Also, 1,10-phenanthroline acts as a neutral bidentate ligand coordinates to the metal ion center via two nitrogen atoms. Additionally, mixed ligand complexes were screened against pathogenic antibacterial and antifungal strains: two Gram (+) bacteria; Streptococcus pneumoniae and Bacillis subtilis, two Gram (−); Pseudomonas aeruginosa and Escherichia coli and four fungi; Aspergillus fumigatu, Syncephalastrum racemosum, Geotricum candidum and Candida albicans. The breast cancer cell line MCF7 anticancer activity was studied and a moderate result was the main observation. Molecular docking studies of the HL ligand and its mixed Fe(III), Ni(II) and Cu(II) metal complexes with 1,10-phenanthroline showed the nature of binding energy, H-bond and hydrophobic interactions with the crystal structure of: Tyrosine kinase auto-inhibitor (PDB: 1T46), Staphylococcus aureus nucleoside (PDB: 3Q8U), Human papillomavirus (HPV) pro-apoptotic tumor suppressor (PDB: 4XR8) and breast cancer mutant oxidoreductase (PDB ID: 3HB5). Ausführliche Beschreibung