The expression of vesicular glutamate transporter 3 and vesicular monoamine transporter 2 induced by brain-derived neurotrophic factor in dorsal root ganglion neurons in vitro

• The effects of BDNF on VGLUT3 and VMAT2 expression in DRG neurons were assessed. • BDNF upregulated VGLUT3, but not VMAT2 expression in cultured DRG neurons. • BDNF induced VGLUT3 upregulation through PLC-γ signaling pathway. • Inhibition of PI3K/Akt or PLC-γ inhibited VMAT2 expression in the pres...
Ausführliche Beschreibung

• The effects of BDNF on VGLUT3 and VMAT2 expression in DRG neurons were assessed. • BDNF upregulated VGLUT3, but not VMAT2 expression in cultured DRG neurons. • BDNF induced VGLUT3 upregulation through PLC-γ signaling pathway. • Inhibition of PI3K/Akt or PLC-γ inhibited VMAT2 expression in the presence of BDNF. • The promotion of VGLUT3 by BDNF might be by improving neuronal outgrowth status. Ausführliche Beschreibung