Does the crystal habit modulate the genotoxic potential of silica particles? A cytogenetic evaluation in human and murine cell lines

• Crystalline and amorphous silica sharing the same surface features were used. • Genotoxic potential of pure quartz and vitreous silica was tested in vitro. • Human pulmonary epithelial and murine macrophages cell lines were selected. • Comet assay, micronucleus test, trypan blue method were select...
Ausführliche Beschreibung

• Crystalline and amorphous silica sharing the same surface features were used. • Genotoxic potential of pure quartz and vitreous silica was tested in vitro. • Human pulmonary epithelial and murine macrophages cell lines were selected. • Comet assay, micronucleus test, trypan blue method were selected. • Quartz induced increased DNA damage in murine macrophages but not in human cells. Ausführliche Beschreibung