Molecular bases of antifungal resistance in filamentous fungi

• Invasive mould infections are associated with substantial healthcare use and mortality rates in immunocompromised patients. • The burden of antifungal resistance in high-risk patients is becoming a major concern. • Azole resistance in Aspergillus spp. is attributed to cyp51A and non-cyp51A mutatio...
Ausführliche Beschreibung

• Invasive mould infections are associated with substantial healthcare use and mortality rates in immunocompromised patients. • The burden of antifungal resistance in high-risk patients is becoming a major concern. • Azole resistance in Aspergillus spp. is attributed to cyp51A and non-cyp51A mutations. • Polyene and echinocandin resistance mechanisms are less understood in Aspergillus spp. • Non-rational use of fungicides increases the risk of antifungal resistance in agriculture and medicine. Ausführliche Beschreibung