Receptor-heteromer mediated regulation of endocannabinoid signaling in activated microglia. Role of CB<ce:inf loc="post">1</ce:inf> and CB<ce:inf loc="post">2</ce:inf> receptors and relevance for Alzheimer’s disease and levodopa-induced dyskinesia

• LPS plus interferon-γ upregulate CB2 receptors in microglia. • LPS plus interferon-γ upregulate CB1-CB2 receptor complexes in microglia. • ß amyloid and LPS plus interferon-γ lead to similar activation traits in microglia. • Activated microglia is identified in pups of an Alzheimer’s disease model...
Ausführliche Beschreibung

• LPS plus interferon-γ upregulate CB2 receptors in microglia. • LPS plus interferon-γ upregulate CB1-CB2 receptor complexes in microglia. • ß amyloid and LPS plus interferon-γ lead to similar activation traits in microglia. • Activated microglia is identified in pups of an Alzheimer’s disease model. • Dyskinesia in Parkinson’s correlates with CB1-CB2 receptor complex upregulation. Ausführliche Beschreibung