Effect of colibacillosis on the immune response to a rabbit viral haemorrhagic disease vaccine

• Effect of colibacillosis on the immune response to a rabbit viral haemorrhagic disease vaccine was evaluated. • Significant clinical signs and mortality and a decrease in BWG were observed in the infected vaccinated group. • The infected vaccinated group had significantly higher intestinal levels...
Ausführliche Beschreibung

• Effect of colibacillosis on the immune response to a rabbit viral haemorrhagic disease vaccine was evaluated. • Significant clinical signs and mortality and a decrease in BWG were observed in the infected vaccinated group. • The infected vaccinated group had significantly higher intestinal levels of TNF-α and IL-6 than the other groups. • The infected vaccinated group showed immunosuppression by phagocytic activity, CD4+/CD8+ ratio, HI titers and H/L ratio. • Colibacillosis led to changes in cytokines and could be a contributing factor in RHDV vaccination failure in rabbits. Ausführliche Beschreibung