In vitro and in silico inhibitory effects of synthetic and natural eugenol derivatives against the NorA efflux pump in Staphylococcus aureus

• Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrat...
Ausführliche Beschreibung

• Compounds with the most functional groups obtained clinically relevant results. • Against SA 1199B only isoeugenol had direct antibacterial activity. • For the NorA carrier strain 4-allyl-2-6-dimethoxyphenol, eugenol and isoeugenol potentiated the action of the antibiotic. • The docking demonstrated the hydrogen bonds and hydrophobic interactions are key for NorA inhibition. • The 4-Allyl-2,6-dimetoxyphenol compound as a lead compound as NorA inhibitors. Ausführliche Beschreibung