RPS5 interacts with the rabbit hemorrhagic disease virus 3' extremities region and plays a role in virus replication

• Many host proteins are associated with RHDV 5' and 3' extremities (Ex) RNA. • Ribosomal protein S5 (RPS5) interacts with RHDV 3' Ex RNA. • RPS5 plays a role in RHDV replication. • The findings will help understand the mechanism of RHDV replication.