The impact of aging in dementia: It is time to refocus attention on the main risk factor of dementia

• Alzheimer’s disease (AD) represents the most common form of dementia in old age subjects.. • Disease-modifier therapies and based on the amyloid hypothesis have failed in RCTs and no cure is available up to now. • In old age neurodegeneration is related to a progressive energetic failure causing,...
Ausführliche Beschreibung

• Alzheimer’s disease (AD) represents the most common form of dementia in old age subjects.. • Disease-modifier therapies and based on the amyloid hypothesis have failed in RCTs and no cure is available up to now. • In old age neurodegeneration is related to a progressive energetic failure causing, among other damages, amyloid accumulation. • The optimization of brain energetics should become a key component in future strategies for preventing and treating dementia. Ausführliche Beschreibung