Interleukin-1 beta is significantly upregulated in the decidua of spontaneous and recurrent miscarriage placentas

• IL-1β gene expression is 54-times higher in placental tissue of recurrent abortion compared to controls. • Immunohistochemistry confirmed a significant upregulation of IL-1β in the decidua of recurrent miscarriage specimens. • Double-immunofluorescence identified decidual stoma cells as IL-1β expr...
Ausführliche Beschreibung

• IL-1β gene expression is 54-times higher in placental tissue of recurrent abortion compared to controls. • Immunohistochemistry confirmed a significant upregulation of IL-1β in the decidua of recurrent miscarriage specimens. • Double-immunofluorescence identified decidual stoma cells as IL-1β expressing cells. • Decidual upregulation of IL-1β may be associated with an imbalanced maternal immune system in early pregnancy loss. Ausführliche Beschreibung