miR-383 reduces keratinocyte proliferation and induces the apoptosis in psoriasis via disruption of LCN2-dependent JAK/STAT pathway activation

• miR-383 downregulation and LCN2 upregulation were detected in psoriasis rats. • miR-383 inhibited LCN2 and activated JAK/STAT pathway in psoriasis. • miR-383 overexpression or LCN2 knockdown attenuated psoriasis-like symptoms. • miR-383 overexpression or LCN2 knockdown inhibited keratinocytes prol...
Ausführliche Beschreibung

• miR-383 downregulation and LCN2 upregulation were detected in psoriasis rats. • miR-383 inhibited LCN2 and activated JAK/STAT pathway in psoriasis. • miR-383 overexpression or LCN2 knockdown attenuated psoriasis-like symptoms. • miR-383 overexpression or LCN2 knockdown inhibited keratinocytes proliferation. • The study provided promising therapeutic targets for psoriasis treatment. Ausführliche Beschreibung