NMDA receptors elicit flux-independent intracellular Ca2+ signals via metabotropic glutamate receptors and flux-dependent nitric oxide release in human brain microvascular endothelial cells

• NMDA causes an increase in [Ca2+]i in the human brain microvascular endothelial cell line, hCMEC/D3. • NMDARs increase the [Ca2+]i in a flux-independent manner via group 1 mGluRs. • NMDARs may also induce NO release by signaling in a flux-dependent manner. • Endothelial NMDA receptors exploit both...
Ausführliche Beschreibung

• NMDA causes an increase in [Ca2+]i in the human brain microvascular endothelial cell line, hCMEC/D3. • NMDARs increase the [Ca2+]i in a flux-independent manner via group 1 mGluRs. • NMDARs may also induce NO release by signaling in a flux-dependent manner. • Endothelial NMDA receptors exploit both canonical and non-canonical signaling modes. Ausführliche Beschreibung