Neural underpinnings of emotion regulation subgroups in remitted patients with recently diagnosed bipolar disorder

• Neural activity during emotion regulation can distinguish discrete neuronal subgroups. • Patients with bipolar disorder were optimally clustered into two neuronal subgroups. • Subgroup 1 exhibited bilateral amygdala hyperactivity. • Subgroup 2 showed widespread hypoactivity within the emotion regu...
Ausführliche Beschreibung

• Neural activity during emotion regulation can distinguish discrete neuronal subgroups. • Patients with bipolar disorder were optimally clustered into two neuronal subgroups. • Subgroup 1 exhibited bilateral amygdala hyperactivity. • Subgroup 2 showed widespread hypoactivity within the emotion regulation network. • Amygdala hyperactivity was associated with increased risk of subsequent relapse. • Neuronal subgroups suggest neurobiological heterogeneity within bipolar disorder. Ausführliche Beschreibung