Study of the manganese and calcium synergetic influence on mesoporous bioactive glass characteristic

Mesoporous bioactive glasses nanoparticles (MBGNPs) have shown great potential for tissue regeneration, and therapeutic ions incorporation into the glass system is a potential strategy to improve its performance. Here, manganese ions, known to favor osteogenic differentiation, were incorporated usin...
Ausführliche Beschreibung

Mesoporous bioactive glasses nanoparticles (MBGNPs) have shown great potential for tissue regeneration, and therapeutic ions incorporation into the glass system is a potential strategy to improve its performance. Here, manganese ions, known to favor osteogenic differentiation, were incorporated using a post-synthesis impregnation method, and the Mn influence into the SiO2-CaO structure and properties were evaluated. Morphological analysis confirmed that spherical mesoporous BGNPs with up to 67 ± 24 nm were obtained, and x-ray photoelectron spectroscopy showed that Mn could be incorporated into the glass as a network modifier or deposited as a manganese oxide crystalline phase, forming a bioactive glass-ceramic material. A cell-friendly environment and osteogenic potential was observed in cellular assays, with a manganese dose-dependent effect on cell viability and alkaline phosphatase activity. Thus, results indicate that Mn-releasing MBGNPs could be obtained through the post-synthesis impregnation method and are promising candidates for bone repair. Ausführliche Beschreibung