Na fluxes in human mononuclear leucocytes

Summary Unidirectional22Na fluxes were investigated in human peripheral mononuclear leucocytes. Oua bain inhibited about 60% of Na efflux and the addition of bumetanide further reduced Na efflux rate by about 45%, sugesting the presence of a transport pathway capable of extruding Na against its grad...
Ausführliche Beschreibung

Summary Unidirectional22Na fluxes were investigated in human peripheral mononuclear leucocytes. Oua bain inhibited about 60% of Na efflux and the addition of bumetanide further reduced Na efflux rate by about 45%, sugesting the presence of a transport pathway capable of extruding Na against its gradient. Prostaglandins E1 and E2 and exogenous cAMP were found to be potent inhibitors of the bumetanide-sensitive Na efflux without affecting the ouabain-sensitive or the ouabain sensitive or the ouabain and bumetanide resistant Na effluxes. Ausführliche Beschreibung