Homozygous prion protein genotype predisposes to sporadic Creutzfeldt–Jakob disease

[Auszug] The prion protein (PrP) gene encodes a normal cell-surface glycoprotein found on neuronal cells, lymphocytes and other tissues7'8. Coding mutations (Fig. 1) have been found in familial CJD, GSS and also in atypical familial dementias now known to be part ...