Fully Interconnected Globular Porous Biphasic Calcium Phosphate Ceramic Scaffold Facilitates Osteogenic Repair

An appropriate scaffold, which provides structural support for transplanted cells and actsas a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. Wedeveloped a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold byadopting a fo...
Ausführliche Beschreibung

An appropriate scaffold, which provides structural support for transplanted cells and actsas a vehicle for the delivery of biologically active molecules, is critical for tissue engineering. Wedeveloped a fully interconnected globular porous biphasic calcium phosphate ceramic scaffold byadopting a foaming method, and evaluated its efficiency as a bone substitute and a scaffold for bonetissue engineering by in vitro and in vivo biocompatible analysis and its osteogenic healing capacityin rat tibial bone defects. They have spherical pores averaging 400um in diameter and interconnectinginterpores averaging 70um in diameter with average 85% porosity. They elicited no cytotoxicity andnoxious effect on cellular proliferation and osteoblastic differentiation during the cell-scaffoldconstruct formation. Also the bone defects grafted with fully interconnected globular porous biphasiccalcium phosphate ceramic blocks revealed excellent bone healing within 3 weeks. These findingssuggest that the fully interconnected porous biphasic calcium phosphate scaffold formed by thefoaming method can be a promising bone substitute and a scaffold for bone tissue engineering Ausführliche Beschreibung