PLATELET MONOAMINE OXIDASE ACTIVITY IN PATIENTS WITH HUNTINGTON'S DISEASE

1. Platelet monoamine oxidase (MAO) activity was investigated in 30 patients with Huntington's disease and compared with the activity in a control group.2. Significantly elevated activity was found in the patients (P < 0.05; t-test) when same sex contrasts were carried out to account for the...
Ausführliche Beschreibung

1. Platelet monoamine oxidase (MAO) activity was investigated in 30 patients with Huntington's disease and compared with the activity in a control group.2. Significantly elevated activity was found in the patients (P < 0.05; t-test) when same sex contrasts were carried out to account for the well known influence of sex on MAO activity.3. The mean MAO activity in male patients was 23.5±6.0 nmol/mg protein per h and female patients was 29.5 ± 8.9 nmol/mg protein per h using tyramine as the substrate.4. The possible influence of environmental factors on the results is discussed. Ausführliche Beschreibung