Early amplitude-integrated EEG monitoring 6 h after birth predicts long-term neurodevelopment of asphyxiated late preterm infants

Abstract The present study aimed to assess the prognostic value of early amplitude-integrated electroencephalogram (aEEG) in late preterm infants who were born at a gestational age between 34 0/7 and 36 6/7 weeks for the prediction of neurobehavioral development. Late preterm infants (n = 170) with...
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Abstract The present study aimed to assess the prognostic value of early amplitude-integrated electroencephalogram (aEEG) in late preterm infants who were born at a gestational age between 34 0/7 and 36 6/7 weeks for the prediction of neurobehavioral development. Late preterm infants (n = 170) with normal, mild, and severe asphyxia underwent continuous recording of aEEG for 4–6 h starting 6–8 h after delivery. The recordings were analyzed for background pattern, sleep-wake cycle (SWC), and seizures. Survivors were assessed at 18 months by neurological examination and Bayley Scales of Infant Development II. The incidence of adverse neurological outcome in the asphyxia group was significantly higher than in the normal group. For late preterm infants in the asphyxia group, abnormal aEEG pattern had a predictive potential of neurological outcomes with sensitivity of 78.57 % (specificity, 87.80 %; positive predictive value [PPV], 68.75 %; negative predictive value [NPV], 92.31 %; power, 85.45 %). Non-SWC and intermediate SWC significantly were increased (25.45 and 52.73 %, respectively) in the asphyxia group vs. the normal group. SWC pattern had neurological prognosis value in the asphyxia group with sensitivity of 64.29 % (specificity, 87.80 %; PPV, 64.29 %; NPV, 87.80 %; power, 81.82 %). Conclusion: Early aEEG patterns are important determinants of long-term prognosis of neurodevelopmental outcome in asphyxiated late preterm infants.What is Known:• Perinatal asphyxia has been reported to lead to adverse long-term neurological outcome of late preterm infants. Early amplitude-integrated EEG (aEEG) is a valuable method in predicting the long-term prognosis within the first 6 h of birth in the neonatal intensive care units.What is New:• The results suggest that the aEEG pattern is an important determinant of long-term prognosis of neurodevelopmental outcome in asphyxiated late preterm infants. Ausführliche Beschreibung