Influence of optic media of the human eye on the imaging of Argus® II retinal prosthesis with intraoperative spectral-domain optical coherence tomography

Background This study aimed to evaluate the influence of the optic media of the human eye on intraoperative spectral-domain optical coherence tomography (iSD-OCT) of an Argus® II retinal prosthesis (AIIRP) during its implantation. Methods One AIIRP was implanted in a human eye with end-stage retinit...
Ausführliche Beschreibung

Background This study aimed to evaluate the influence of the optic media of the human eye on intraoperative spectral-domain optical coherence tomography (iSD-OCT) of an Argus® II retinal prosthesis (AIIRP) during its implantation. Methods One AIIRP was implanted in a human eye with end-stage retinitis pigmentosa and another one in a test eye. Intraoperative imaging was performed using the Rescan™ 700, a microscope-integrated iSD-OCT system. The feasibility of iSD-OCT imaging for AIIRP implantation was assessed during different surgical steps. Data were post-processed postoperatively using the ImageJ graphic software. Results The quality of imaging of the AIIRP during its implantation was good and almost the same in the human eye and in the training eye. The histograms showed that the optic media had no impact on the quality of iSD-OCT scans, as the difference between the pixel values was not statistically significant. Additionally, the quality of iSD-OCT imaging of the retina under the AIIRP array was not decreased by the array itself. Conclusion The iSD-OCT-assisted surgical approach facilitates imaging of the AIIRP during its implantation. Uncompromised human optic media do not reduce the quality of AIIRP array imaging throughout all the surgical steps. The influence of the opaque cornea in long-lasting surgeries on the iSD-OCT scan quality during AIIRP implantation has to be investigated. Ausführliche Beschreibung