Design and therapeutic application of sodium alginate-based hydrogel with biodegradability and catalytic activity

Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe...
Ausführliche Beschreibung

Abstract How to efficiently treat cancer in a minimally invasive manner has become one of the major focuses of recent developments in biomedicine. In this research, biodegradable sodium alginate (SA) hydrogel encapsulated with $ NaHCO_{3} $ and glucose oxidase ($ GO_{X} $) was synthesized using $ Fe^{3+} $ as the crosslinker for the tumor chemodynamic therapy (CDT) and starvation therapy (ST). Material safety assessments revealed that this hydrogel possesses good in vitro and in vivo security. In tumor microenvrionment (TME), the $ Fe^{3+} $ further reacted with the intracellular glutathione and was transformed into $ Fe^{2+} $, which triggered the Fenton reaction with the $ H_{2} %$ O_{2} $ within TME and produced abundant highly toxic ·OH (hydroxyl radicals) for efficient tumor CDT. Furthermore, the $ GO_{X} $ catalyzed the enzymolysis of glucose to consume the nutrient of the tumor and enhance the $ H_{2} %$ O_{2} $ level in TME. Besides, the $ CO_{2} $ bubbles that were generated from the decomposing of $ NaHCO_{3} $ promoted the contact between glucose and $ GO_{X} $. Findings in this research would have important implications for the present status of tumor therapy. Ausführliche Beschreibung