Examining Barriers and Opportunities of Conducting Genome-Wide Association Studies in Developing Countries

Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of indi...
Ausführliche Beschreibung

Purpose of Review Genome-wide association studies (GWASs) allow correlations between genetic variations and diseases that will benefit the field of public health in developing countries. It is considered to be the primary step toward a journey from gene discovery to improving health outcomes of individuals. The aim of this manuscript was to examine barriers and opportunities of conducting GWASs in selected developing nations by considering a holistic set of elements including demand, resources, implementation/practicality, and adaptation. Recent Findings Consideration of various aforementioned elements shows that while some developing countries exhibit great potential in performing GWAS research, several factors are still hindering progress toward this direction including adaptation/integration, proper governance, and availability of human and financial resources. Summary This informative analysis provided information that determined and considered various factors that make it challenging to conduct GWAS in developing nations. United efforts from genetic research institutions (i.e., multicenter collaboration) and government health agencies are recommended to successfully implement GWASs in developing economies. Ausführliche Beschreibung