New Paradigms in Hypersensitivity Pneumonitis

Purpose of Review This review aims to briefly discuss the new paradigms explored in the recent past especially for the diagnosis and treatment of hypersensitivity pneumonitis (HP). Recent Findings HP has now been classified into non-fibrotic and fibrotic phenotypes. The diagnosis of non-fibrotic and...
Ausführliche Beschreibung

Purpose of Review This review aims to briefly discuss the new paradigms explored in the recent past especially for the diagnosis and treatment of hypersensitivity pneumonitis (HP). Recent Findings HP has now been classified into non-fibrotic and fibrotic phenotypes. The diagnosis of non-fibrotic and fibrotic HP has been categorized into “typical,” “compatible,” and “indeterminate” in terms of radiology and histopathology, grading the degree of diagnostic confidence. The newly explored role of antifibrotic drugs provides a treatment prospect for patients with fibrotic HP whose options were largely limited to corticosteroids and immunosuppressants. Summary The official guidelines provide us with a systematic approach towards making a confident diagnosis of HP and its subtypes. Recent pharmacological studies have enlightened our knowledge with a variety of treatment options, especially for fibrotic HP. However, a multitude of questions still remain unanswered. Ausführliche Beschreibung