P8.7 Vascular Endothelial Senescence and Metabolic Syndrome

Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is stil...
Ausführliche Beschreibung

Introduction Increased arterial stiffness is a marker of cardiovascular disease and suggested to beassociated with impaired lung function in chronic obstructive pulmonary disease (COPD). However, whether patients with mild COPD have increased arterial stiffness and what factors are linked to is still not explicitly studied. We hypothesised that patients with mild COPD would have increased arterial stiffness than controls independent of lung function. Methods As part of the ARCADE study, 70 patients with mild COPD and 150 controls free from lung disease were examined. Aortic pulse wave velocity (PWV), spirometry, body composition, blood pressure (BP), heart rate (HR) and C-reactive protein (CRP) were determined. Results Patients and controls were similar in age, body composition and gender. However, patients had greater aortic PWV 9.4 (1.96) m/s, systolic BP 147 (18) mmHg, HR 72 (12) bpm and CRP* 3.1 (1.7) mg/l compared with controls PWV 8.4 (1.8) m/s, BP 140 (18) mmHg, HR 67 (10) bpm and CRP* 1.7 (1.6) mg/l, all p<0.001. Aortic PWV was related to HR in patients (r = 0.39) and controls (r = 0.26), all p<0.001. A stepwise regression analysis adjusted for age and MAP showed heart rate was only predictor of increased aortic PWV (Adjusted R2 = 33%, p<0.001) where waist circumference and HR in the controls (Adjusted R2 = 37%, p<0.001). Conclusion Increased heart rate accelerates atherosclerosis process and vascular dysfunction and ultimately leads to increased incidence rate of coronary artery disease. Understanding the relationship between increased heart rate and greater aortic stiffness would allow for cardioprotective effect of lowering heart rate. Ausführliche Beschreibung