P96: Acute Effect of Electronic Cigarette Smoking on Pulse Pressure Amplification in Young Smokers

Purpose/Background/Objectives We investigated the acute effect of electronic cigarette (EC) smoking on the aortic pressure waveform amplification. We also sought to compare the effect of EC and combustible cigarette (TC) smoking on central haemodynamics. Methods We studied 24 smokers (age: 30 ± 8 ye...
Ausführliche Beschreibung

Purpose/Background/Objectives We investigated the acute effect of electronic cigarette (EC) smoking on the aortic pressure waveform amplification. We also sought to compare the effect of EC and combustible cigarette (TC) smoking on central haemodynamics. Methods We studied 24 smokers (age: 30 ± 8 years) on 3 separate occasions: a) tobacco cigarette (nicotine content, 1.2 mg) over 5 minutes, b) EC (18 mg E-liquid) for a period of 30 minutes, and c) nothing (sham procedure) for 60 minutes. Smoking EC for 30 min (15 puffs) was chosen to mimic the common pattern of EC smoking. Results Both TC and EC smoking caused a significant increase in brachial pressures and heart rate (HR), and the differences in blood pressure (BP) and HR responses between the two smoking forms were not significant. The aortic pressures also increased significantly after smoking both TC and EC, with the greatest changes seen in the first 5 minutes after TC smoking and 15 minutes EC smoking (figures 1A- C, all P < 0.05). Although AIx, decreased in both two smoking forms, by applying a correction factor for changes in HR, the AIx increased significantly after TC (by 3.0% at 5 minutes, P < 0.05) and EC (by 2.9% at 15 minutes, P < 0.05) (figure 1D). Conclusions Electronic cigarette smoking exerts an unfavourable and comparable to that of TC smoking acute effect on aortic pressure waveform amplification. Given the prognostic role of central haemodynamics on cardiovascular disease risk, EC may still be considered a hazardous smoking method. Ausführliche Beschreibung