A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae

<b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-...
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Autor*in:	Mracskó, Eva [verfasserIn] Stegemann-Koniszewski, Sabine [verfasserIn] Na, Shin-Young - 1975- [verfasserIn] Dalpke, Alexander - 1971- [verfasserIn] Bruder, Dunja - 1971- [verfasserIn] Lasitschka, Felix - 1979- [verfasserIn] Veltkamp, Roland - 1966- [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	January 4, 2017

Umfang:	11

Übergeordnetes Werk:	Enthalten in: Cerebrovascular diseases - Basel : Karger, 1991, 43(2017), 3/4, Seite 99-109
Übergeordnetes Werk:	volume:43 ; year:2017 ; number:3/4 ; pages:99-109 ; extent:11

Links:	Volltext Volltext

DOI / URN:	10.1159/000452136

Katalog-ID:	1001936094

Internformat


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245	1	2	\|a A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae \|c Eva Mracsko, Sabine Stegemann-Koniszewski, Shin-Young Na, Alexander Dalpke, Dunja Bruder, Felix Lasitschka, Roland Veltkamp
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520			\|a <b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke. <b><i>Methods:</i></b> Bacterial pneumonia was induced by intra-tracheal inoculation with <i>Streptococcus pneumoniae</i> at different time points after transient middle cerebral artery occlusion (MCAO). Bacterial counts in lungs and blood, histological changes, and cytokine production in the lungs were assessed. Furthermore, we investigated the effect of pneumonia on stroke outcome. <b><i>Results:</i></b> Intra-tracheal inoculation resulted in reproducible pneumonia and bacteraemia, and demonstrated post-stroke susceptibility to streptococcal pneumonia developing with a delay of at least 24 h after MCAO. Higher bacterial counts in mice infected 3 days after stroke induction correlated with reduced neutrophil and macrophage infiltration in the lungs and lower levels of pro-inflammatory cytokines in the broncho-alveolar lavage compared to sham-operated animals. Pneumonia increased mortality without affecting brain-infiltrating leukocytes. <b><i>Conclusions:</i></b> In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome.
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Indexfelder

author_variant	e m em s s k ssk s y n syn a d ad d b db f l fl r v rv
matchkey_str	article:14219786:2017----::mueoeopssrkpemnanuebitarcelncltowt
oclc_num	1340370351
hierarchy_sort_str	January 4, 2017
publishDate	2017
allfields	10.1159/000452136 doi (DE-627)1001936094 (DE-599)GBV1001936094 (OCoLC)1340370351 DE-627 ger DE-627 rda eng Mracskó, Eva verfasserin (DE-588)1072724669 (DE-627)828145822 (DE-576)434206911 aut A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae Eva Mracsko, Sabine Stegemann-Koniszewski, Shin-Young Na, Alexander Dalpke, Dunja Bruder, Felix Lasitschka, Roland Veltkamp January 4, 2017 11 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke. <b><i>Methods:</i></b> Bacterial pneumonia was induced by intra-tracheal inoculation with <i>Streptococcus pneumoniae</i> at different time points after transient middle cerebral artery occlusion (MCAO). Bacterial counts in lungs and blood, histological changes, and cytokine production in the lungs were assessed. Furthermore, we investigated the effect of pneumonia on stroke outcome. <b><i>Results:</i></b> Intra-tracheal inoculation resulted in reproducible pneumonia and bacteraemia, and demonstrated post-stroke susceptibility to streptococcal pneumonia developing with a delay of at least 24 h after MCAO. Higher bacterial counts in mice infected 3 days after stroke induction correlated with reduced neutrophil and macrophage infiltration in the lungs and lower levels of pro-inflammatory cytokines in the broncho-alveolar lavage compared to sham-operated animals. Pneumonia increased mortality without affecting brain-infiltrating leukocytes. <b><i>Conclusions:</i></b> In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome. Stegemann-Koniszewski, Sabine verfasserin aut Na, Shin-Young 1975- verfasserin (DE-588)130288810 (DE-627)49736476X (DE-576)298107805 aut Dalpke, Alexander 1971- verfasserin (DE-588)123821878 (DE-627)706438523 (DE-576)293894272 aut Bruder, Dunja 1971- verfasserin (DE-588)12209588X (DE-627)08173316X (DE-576)293089272 aut Lasitschka, Felix 1979- verfasserin (DE-588)140496343 (DE-627)618903542 (DE-576)318526077 aut Veltkamp, Roland 1966- verfasserin (DE-588)172858453 (DE-627)697787567 (DE-576)133713997 aut Enthalten in Cerebrovascular diseases Basel : Karger, 1991 43(2017), 3/4, Seite 99-109 Online-Ressource (DE-627)300189834 (DE-600)1482069-9 (DE-576)097267651 1421-9786 nnns volume:43 year:2017 number:3/4 pages:99-109 extent:11 http://dx.doi.org/10.1159/000452136 Resolving-System Volltext https://www.karger.com/Article/FullText/452136 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_178 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 GBV_ILN_2013 GBV_ILN_2013 ISIL_DE-16-250 AR 43 2017 3/4 99-109 11 178 01 3178 171930761X x 26-10-17 2013 01 DE-16-250 3418128556 00 --%%-- --%%-- --%%-- --%%-- l01 04-04-19 178 00 3178 00 (DE-627)504264362 Institut für Medizinische Mikrobiologie und Krankenhaushygiene <Magdeburg> 178 00 3178 01 Stegemann-Koniszewski, Sabine / IMMB 178 00 3178 02 Bruder, Dunja / IMMB 178 00 3178 03 (DE-627)719906830 begutachteter Zeitschriftenartikel (peer reviewed) 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_7 2013 01 DE-16-250 03 s s_11 2013 01 DE-16-250 04 p (DE-627)1504211979 Mracskó, Eva 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1575453495 Na, Shin-Young 2013 01 DE-16-250 05 k (DE-627)1416822720 Extern 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_3 2013 01 DE-16-250 06 p (DE-627)1451543956 Dalpke, Alexander 2013 01 DE-16-250 06 k (DE-627)1495544966 Zentrum für Infektiologie 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1430431717 Lasitschka, Felix 2013 01 DE-16-250 07 k (DE-627)1416741658 Pathologisches Institut 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_6 2013 01 DE-16-250 08 p (DE-627)1450171036 Veltkamp, Roland 2013 01 DE-16-250 08 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_7 178 00 3178 00 Impact factor: 2.974 178 01 3178 99 j2017
spelling	10.1159/000452136 doi (DE-627)1001936094 (DE-599)GBV1001936094 (OCoLC)1340370351 DE-627 ger DE-627 rda eng Mracskó, Eva verfasserin (DE-588)1072724669 (DE-627)828145822 (DE-576)434206911 aut A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae Eva Mracsko, Sabine Stegemann-Koniszewski, Shin-Young Na, Alexander Dalpke, Dunja Bruder, Felix Lasitschka, Roland Veltkamp January 4, 2017 11 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke. <b><i>Methods:</i></b> Bacterial pneumonia was induced by intra-tracheal inoculation with <i>Streptococcus pneumoniae</i> at different time points after transient middle cerebral artery occlusion (MCAO). Bacterial counts in lungs and blood, histological changes, and cytokine production in the lungs were assessed. Furthermore, we investigated the effect of pneumonia on stroke outcome. <b><i>Results:</i></b> Intra-tracheal inoculation resulted in reproducible pneumonia and bacteraemia, and demonstrated post-stroke susceptibility to streptococcal pneumonia developing with a delay of at least 24 h after MCAO. Higher bacterial counts in mice infected 3 days after stroke induction correlated with reduced neutrophil and macrophage infiltration in the lungs and lower levels of pro-inflammatory cytokines in the broncho-alveolar lavage compared to sham-operated animals. Pneumonia increased mortality without affecting brain-infiltrating leukocytes. <b><i>Conclusions:</i></b> In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome. Stegemann-Koniszewski, Sabine verfasserin aut Na, Shin-Young 1975- verfasserin (DE-588)130288810 (DE-627)49736476X (DE-576)298107805 aut Dalpke, Alexander 1971- verfasserin (DE-588)123821878 (DE-627)706438523 (DE-576)293894272 aut Bruder, Dunja 1971- verfasserin (DE-588)12209588X (DE-627)08173316X (DE-576)293089272 aut Lasitschka, Felix 1979- verfasserin (DE-588)140496343 (DE-627)618903542 (DE-576)318526077 aut Veltkamp, Roland 1966- verfasserin (DE-588)172858453 (DE-627)697787567 (DE-576)133713997 aut Enthalten in Cerebrovascular diseases Basel : Karger, 1991 43(2017), 3/4, Seite 99-109 Online-Ressource (DE-627)300189834 (DE-600)1482069-9 (DE-576)097267651 1421-9786 nnns volume:43 year:2017 number:3/4 pages:99-109 extent:11 http://dx.doi.org/10.1159/000452136 Resolving-System Volltext https://www.karger.com/Article/FullText/452136 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_178 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 GBV_ILN_2013 GBV_ILN_2013 ISIL_DE-16-250 AR 43 2017 3/4 99-109 11 178 01 3178 171930761X x 26-10-17 2013 01 DE-16-250 3418128556 00 --%%-- --%%-- --%%-- --%%-- l01 04-04-19 178 00 3178 00 (DE-627)504264362 Institut für Medizinische Mikrobiologie und Krankenhaushygiene <Magdeburg> 178 00 3178 01 Stegemann-Koniszewski, Sabine / IMMB 178 00 3178 02 Bruder, Dunja / IMMB 178 00 3178 03 (DE-627)719906830 begutachteter Zeitschriftenartikel (peer reviewed) 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_7 2013 01 DE-16-250 03 s s_11 2013 01 DE-16-250 04 p (DE-627)1504211979 Mracskó, Eva 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1575453495 Na, Shin-Young 2013 01 DE-16-250 05 k (DE-627)1416822720 Extern 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_3 2013 01 DE-16-250 06 p (DE-627)1451543956 Dalpke, Alexander 2013 01 DE-16-250 06 k (DE-627)1495544966 Zentrum für Infektiologie 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1430431717 Lasitschka, Felix 2013 01 DE-16-250 07 k (DE-627)1416741658 Pathologisches Institut 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_6 2013 01 DE-16-250 08 p (DE-627)1450171036 Veltkamp, Roland 2013 01 DE-16-250 08 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_7 178 00 3178 00 Impact factor: 2.974 178 01 3178 99 j2017
allfields_unstemmed	10.1159/000452136 doi (DE-627)1001936094 (DE-599)GBV1001936094 (OCoLC)1340370351 DE-627 ger DE-627 rda eng Mracskó, Eva verfasserin (DE-588)1072724669 (DE-627)828145822 (DE-576)434206911 aut A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae Eva Mracsko, Sabine Stegemann-Koniszewski, Shin-Young Na, Alexander Dalpke, Dunja Bruder, Felix Lasitschka, Roland Veltkamp January 4, 2017 11 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke. <b><i>Methods:</i></b> Bacterial pneumonia was induced by intra-tracheal inoculation with <i>Streptococcus pneumoniae</i> at different time points after transient middle cerebral artery occlusion (MCAO). Bacterial counts in lungs and blood, histological changes, and cytokine production in the lungs were assessed. Furthermore, we investigated the effect of pneumonia on stroke outcome. <b><i>Results:</i></b> Intra-tracheal inoculation resulted in reproducible pneumonia and bacteraemia, and demonstrated post-stroke susceptibility to streptococcal pneumonia developing with a delay of at least 24 h after MCAO. Higher bacterial counts in mice infected 3 days after stroke induction correlated with reduced neutrophil and macrophage infiltration in the lungs and lower levels of pro-inflammatory cytokines in the broncho-alveolar lavage compared to sham-operated animals. Pneumonia increased mortality without affecting brain-infiltrating leukocytes. <b><i>Conclusions:</i></b> In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome. Stegemann-Koniszewski, Sabine verfasserin aut Na, Shin-Young 1975- verfasserin (DE-588)130288810 (DE-627)49736476X (DE-576)298107805 aut Dalpke, Alexander 1971- verfasserin (DE-588)123821878 (DE-627)706438523 (DE-576)293894272 aut Bruder, Dunja 1971- verfasserin (DE-588)12209588X (DE-627)08173316X (DE-576)293089272 aut Lasitschka, Felix 1979- verfasserin (DE-588)140496343 (DE-627)618903542 (DE-576)318526077 aut Veltkamp, Roland 1966- verfasserin (DE-588)172858453 (DE-627)697787567 (DE-576)133713997 aut Enthalten in Cerebrovascular diseases Basel : Karger, 1991 43(2017), 3/4, Seite 99-109 Online-Ressource (DE-627)300189834 (DE-600)1482069-9 (DE-576)097267651 1421-9786 nnns volume:43 year:2017 number:3/4 pages:99-109 extent:11 http://dx.doi.org/10.1159/000452136 Resolving-System Volltext https://www.karger.com/Article/FullText/452136 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_178 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 GBV_ILN_2013 GBV_ILN_2013 ISIL_DE-16-250 AR 43 2017 3/4 99-109 11 178 01 3178 171930761X x 26-10-17 2013 01 DE-16-250 3418128556 00 --%%-- --%%-- --%%-- --%%-- l01 04-04-19 178 00 3178 00 (DE-627)504264362 Institut für Medizinische Mikrobiologie und Krankenhaushygiene <Magdeburg> 178 00 3178 01 Stegemann-Koniszewski, Sabine / IMMB 178 00 3178 02 Bruder, Dunja / IMMB 178 00 3178 03 (DE-627)719906830 begutachteter Zeitschriftenartikel (peer reviewed) 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_7 2013 01 DE-16-250 03 s s_11 2013 01 DE-16-250 04 p (DE-627)1504211979 Mracskó, Eva 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1575453495 Na, Shin-Young 2013 01 DE-16-250 05 k (DE-627)1416822720 Extern 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_3 2013 01 DE-16-250 06 p (DE-627)1451543956 Dalpke, Alexander 2013 01 DE-16-250 06 k (DE-627)1495544966 Zentrum für Infektiologie 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1430431717 Lasitschka, Felix 2013 01 DE-16-250 07 k (DE-627)1416741658 Pathologisches Institut 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_6 2013 01 DE-16-250 08 p (DE-627)1450171036 Veltkamp, Roland 2013 01 DE-16-250 08 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_7 178 00 3178 00 Impact factor: 2.974 178 01 3178 99 j2017
allfieldsGer	10.1159/000452136 doi (DE-627)1001936094 (DE-599)GBV1001936094 (OCoLC)1340370351 DE-627 ger DE-627 rda eng Mracskó, Eva verfasserin (DE-588)1072724669 (DE-627)828145822 (DE-576)434206911 aut A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae Eva Mracsko, Sabine Stegemann-Koniszewski, Shin-Young Na, Alexander Dalpke, Dunja Bruder, Felix Lasitschka, Roland Veltkamp January 4, 2017 11 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke. <b><i>Methods:</i></b> Bacterial pneumonia was induced by intra-tracheal inoculation with <i>Streptococcus pneumoniae</i> at different time points after transient middle cerebral artery occlusion (MCAO). Bacterial counts in lungs and blood, histological changes, and cytokine production in the lungs were assessed. Furthermore, we investigated the effect of pneumonia on stroke outcome. <b><i>Results:</i></b> Intra-tracheal inoculation resulted in reproducible pneumonia and bacteraemia, and demonstrated post-stroke susceptibility to streptococcal pneumonia developing with a delay of at least 24 h after MCAO. Higher bacterial counts in mice infected 3 days after stroke induction correlated with reduced neutrophil and macrophage infiltration in the lungs and lower levels of pro-inflammatory cytokines in the broncho-alveolar lavage compared to sham-operated animals. Pneumonia increased mortality without affecting brain-infiltrating leukocytes. <b><i>Conclusions:</i></b> In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome. Stegemann-Koniszewski, Sabine verfasserin aut Na, Shin-Young 1975- verfasserin (DE-588)130288810 (DE-627)49736476X (DE-576)298107805 aut Dalpke, Alexander 1971- verfasserin (DE-588)123821878 (DE-627)706438523 (DE-576)293894272 aut Bruder, Dunja 1971- verfasserin (DE-588)12209588X (DE-627)08173316X (DE-576)293089272 aut Lasitschka, Felix 1979- verfasserin (DE-588)140496343 (DE-627)618903542 (DE-576)318526077 aut Veltkamp, Roland 1966- verfasserin (DE-588)172858453 (DE-627)697787567 (DE-576)133713997 aut Enthalten in Cerebrovascular diseases Basel : Karger, 1991 43(2017), 3/4, Seite 99-109 Online-Ressource (DE-627)300189834 (DE-600)1482069-9 (DE-576)097267651 1421-9786 nnns volume:43 year:2017 number:3/4 pages:99-109 extent:11 http://dx.doi.org/10.1159/000452136 Resolving-System Volltext https://www.karger.com/Article/FullText/452136 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_178 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 GBV_ILN_2013 GBV_ILN_2013 ISIL_DE-16-250 AR 43 2017 3/4 99-109 11 178 01 3178 171930761X x 26-10-17 2013 01 DE-16-250 3418128556 00 --%%-- --%%-- --%%-- --%%-- l01 04-04-19 178 00 3178 00 (DE-627)504264362 Institut für Medizinische Mikrobiologie und Krankenhaushygiene <Magdeburg> 178 00 3178 01 Stegemann-Koniszewski, Sabine / IMMB 178 00 3178 02 Bruder, Dunja / IMMB 178 00 3178 03 (DE-627)719906830 begutachteter Zeitschriftenartikel (peer reviewed) 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_7 2013 01 DE-16-250 03 s s_11 2013 01 DE-16-250 04 p (DE-627)1504211979 Mracskó, Eva 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1575453495 Na, Shin-Young 2013 01 DE-16-250 05 k (DE-627)1416822720 Extern 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_3 2013 01 DE-16-250 06 p (DE-627)1451543956 Dalpke, Alexander 2013 01 DE-16-250 06 k (DE-627)1495544966 Zentrum für Infektiologie 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1430431717 Lasitschka, Felix 2013 01 DE-16-250 07 k (DE-627)1416741658 Pathologisches Institut 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_6 2013 01 DE-16-250 08 p (DE-627)1450171036 Veltkamp, Roland 2013 01 DE-16-250 08 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_7 178 00 3178 00 Impact factor: 2.974 178 01 3178 99 j2017
allfieldsSound	10.1159/000452136 doi (DE-627)1001936094 (DE-599)GBV1001936094 (OCoLC)1340370351 DE-627 ger DE-627 rda eng Mracskó, Eva verfasserin (DE-588)1072724669 (DE-627)828145822 (DE-576)434206911 aut A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae Eva Mracsko, Sabine Stegemann-Koniszewski, Shin-Young Na, Alexander Dalpke, Dunja Bruder, Felix Lasitschka, Roland Veltkamp January 4, 2017 11 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier <b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke. <b><i>Methods:</i></b> Bacterial pneumonia was induced by intra-tracheal inoculation with <i>Streptococcus pneumoniae</i> at different time points after transient middle cerebral artery occlusion (MCAO). Bacterial counts in lungs and blood, histological changes, and cytokine production in the lungs were assessed. Furthermore, we investigated the effect of pneumonia on stroke outcome. <b><i>Results:</i></b> Intra-tracheal inoculation resulted in reproducible pneumonia and bacteraemia, and demonstrated post-stroke susceptibility to streptococcal pneumonia developing with a delay of at least 24 h after MCAO. Higher bacterial counts in mice infected 3 days after stroke induction correlated with reduced neutrophil and macrophage infiltration in the lungs and lower levels of pro-inflammatory cytokines in the broncho-alveolar lavage compared to sham-operated animals. Pneumonia increased mortality without affecting brain-infiltrating leukocytes. <b><i>Conclusions:</i></b> In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome. Stegemann-Koniszewski, Sabine verfasserin aut Na, Shin-Young 1975- verfasserin (DE-588)130288810 (DE-627)49736476X (DE-576)298107805 aut Dalpke, Alexander 1971- verfasserin (DE-588)123821878 (DE-627)706438523 (DE-576)293894272 aut Bruder, Dunja 1971- verfasserin (DE-588)12209588X (DE-627)08173316X (DE-576)293089272 aut Lasitschka, Felix 1979- verfasserin (DE-588)140496343 (DE-627)618903542 (DE-576)318526077 aut Veltkamp, Roland 1966- verfasserin (DE-588)172858453 (DE-627)697787567 (DE-576)133713997 aut Enthalten in Cerebrovascular diseases Basel : Karger, 1991 43(2017), 3/4, Seite 99-109 Online-Ressource (DE-627)300189834 (DE-600)1482069-9 (DE-576)097267651 1421-9786 nnns volume:43 year:2017 number:3/4 pages:99-109 extent:11 http://dx.doi.org/10.1159/000452136 Resolving-System Volltext https://www.karger.com/Article/FullText/452136 Verlag lizenzpflichtig Volltext GBV_USEFLAG_U GBV_ILN_178 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_230 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_374 GBV_ILN_602 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2057 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2107 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2116 GBV_ILN_2119 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2446 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2885 GBV_ILN_2886 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4277 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4328 GBV_ILN_4333 GBV_ILN_4346 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4753 GBV_ILN_2013 GBV_ILN_2013 ISIL_DE-16-250 AR 43 2017 3/4 99-109 11 178 01 3178 171930761X x 26-10-17 2013 01 DE-16-250 3418128556 00 --%%-- --%%-- --%%-- --%%-- l01 04-04-19 178 00 3178 00 (DE-627)504264362 Institut für Medizinische Mikrobiologie und Krankenhaushygiene <Magdeburg> 178 00 3178 01 Stegemann-Koniszewski, Sabine / IMMB 178 00 3178 02 Bruder, Dunja / IMMB 178 00 3178 03 (DE-627)719906830 begutachteter Zeitschriftenartikel (peer reviewed) 2013 01 DE-16-250 00 s hd2017 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_7 2013 01 DE-16-250 03 s s_11 2013 01 DE-16-250 04 p (DE-627)1504211979 Mracskó, Eva 2013 01 DE-16-250 04 k (DE-627)1416822720 Extern 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1575453495 Na, Shin-Young 2013 01 DE-16-250 05 k (DE-627)1416822720 Extern 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_3 2013 01 DE-16-250 06 p (DE-627)1451543956 Dalpke, Alexander 2013 01 DE-16-250 06 k (DE-627)1495544966 Zentrum für Infektiologie 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1430431717 Lasitschka, Felix 2013 01 DE-16-250 07 k (DE-627)1416741658 Pathologisches Institut 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_6 2013 01 DE-16-250 08 p (DE-627)1450171036 Veltkamp, Roland 2013 01 DE-16-250 08 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_7 178 00 3178 00 Impact factor: 2.974 178 01 3178 99 j2017
language	English
source	Enthalten in Cerebrovascular diseases 43(2017), 3/4, Seite 99-109 volume:43 year:2017 number:3/4 pages:99-109 extent:11
sourceStr	Enthalten in Cerebrovascular diseases 43(2017), 3/4, Seite 99-109 volume:43 year:2017 number:3/4 pages:99-109 extent:11
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institution	findex.gbv.de
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sw_local_iln_str_mv	178:Institut für Medizinische Mikrobiologie und Krankenhaushygiene <Magdeburg> 3178:Institut für Medizinische Mikrobiologie und Krankenhaushygiene <Magdeburg> 178:Stegemann-Koniszewski, Sabine / IMMB 3178:Stegemann-Koniszewski, Sabine / IMMB 178:Bruder, Dunja / IMMB 3178:Bruder, Dunja / IMMB 178:begutachteter Zeitschriftenartikel (peer reviewed) 3178:begutachteter Zeitschriftenartikel (peer reviewed) 2013:hd2017 DE-16-250:hd2017 2013:wissenschaftlicher Artikel (Zeitschrift) DE-16-250:wissenschaftlicher Artikel (Zeitschrift) 2013:per_7 DE-16-250:per_7 2013:s_11 DE-16-250:s_11 2013:Mracskó, Eva DE-16-250:Mracskó, Eva 2013:Extern DE-16-250:Extern 2013:Verfasser DE-16-250:Verfasser 2013:pos_1 DE-16-250:pos_1 2013:Na, Shin-Young DE-16-250:Na, Shin-Young 2013:pos_3 DE-16-250:pos_3 2013:Dalpke, Alexander DE-16-250:Dalpke, Alexander 2013:Zentrum für Infektiologie DE-16-250:Zentrum für Infektiologie 2013:pos_4 DE-16-250:pos_4 2013:Lasitschka, Felix DE-16-250:Lasitschka, Felix 2013:Pathologisches Institut DE-16-250:Pathologisches Institut 2013:pos_6 DE-16-250:pos_6 2013:Veltkamp, Roland DE-16-250:Veltkamp, Roland 2013:Neurologische Universitätsklinik DE-16-250:Neurologische Universitätsklinik 2013:pos_7 DE-16-250:pos_7
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container_title	Cerebrovascular diseases
authorswithroles_txt_mv	Mracskó, Eva @@aut@@ Stegemann-Koniszewski, Sabine @@aut@@ Na, Shin-Young @@aut@@ Dalpke, Alexander @@aut@@ Bruder, Dunja @@aut@@ Lasitschka, Felix @@aut@@ Veltkamp, Roland @@aut@@
publishDateDaySort_date	2017-01-01T00:00:00Z
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language_de	englisch
fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">1001936094</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20230428033555.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">171026s2017 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1159/000452136</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)1001936094</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)GBV1001936094</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1340370351</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Mracskó, Eva</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1072724669</subfield><subfield code="0">(DE-627)828145822</subfield><subfield code="0">(DE-576)434206911</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="2"><subfield code="a">A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae</subfield><subfield code="c">Eva Mracsko, Sabine Stegemann-Koniszewski, Shin-Young Na, Alexander Dalpke, Dunja Bruder, Felix Lasitschka, Roland Veltkamp</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">January 4, 2017</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">11</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a"><b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke. <b><i>Methods:</i></b> Bacterial pneumonia was induced by intra-tracheal inoculation with <i>Streptococcus pneumoniae</i> at different time points after transient middle cerebral artery occlusion (MCAO). Bacterial counts in lungs and blood, histological changes, and cytokine production in the lungs were assessed. 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title	A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae
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title_full	A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae Eva Mracsko, Sabine Stegemann-Koniszewski, Shin-Young Na, Alexander Dalpke, Dunja Bruder, Felix Lasitschka, Roland Veltkamp
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title_sort	mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with streptococcus pneumoniae
title_auth	A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae
abstract	<b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke. <b><i>Methods:</i></b> Bacterial pneumonia was induced by intra-tracheal inoculation with <i>Streptococcus pneumoniae</i> at different time points after transient middle cerebral artery occlusion (MCAO). Bacterial counts in lungs and blood, histological changes, and cytokine production in the lungs were assessed. Furthermore, we investigated the effect of pneumonia on stroke outcome. <b><i>Results:</i></b> Intra-tracheal inoculation resulted in reproducible pneumonia and bacteraemia, and demonstrated post-stroke susceptibility to streptococcal pneumonia developing with a delay of at least 24 h after MCAO. Higher bacterial counts in mice infected 3 days after stroke induction correlated with reduced neutrophil and macrophage infiltration in the lungs and lower levels of pro-inflammatory cytokines in the broncho-alveolar lavage compared to sham-operated animals. Pneumonia increased mortality without affecting brain-infiltrating leukocytes. <b><i>Conclusions:</i></b> In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome.
abstractGer	<b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke. <b><i>Methods:</i></b> Bacterial pneumonia was induced by intra-tracheal inoculation with <i>Streptococcus pneumoniae</i> at different time points after transient middle cerebral artery occlusion (MCAO). Bacterial counts in lungs and blood, histological changes, and cytokine production in the lungs were assessed. Furthermore, we investigated the effect of pneumonia on stroke outcome. <b><i>Results:</i></b> Intra-tracheal inoculation resulted in reproducible pneumonia and bacteraemia, and demonstrated post-stroke susceptibility to streptococcal pneumonia developing with a delay of at least 24 h after MCAO. Higher bacterial counts in mice infected 3 days after stroke induction correlated with reduced neutrophil and macrophage infiltration in the lungs and lower levels of pro-inflammatory cytokines in the broncho-alveolar lavage compared to sham-operated animals. Pneumonia increased mortality without affecting brain-infiltrating leukocytes. <b><i>Conclusions:</i></b> In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome.
abstract_unstemmed	<b><i>Background:</i></b> Stroke-induced immunodeficiency increases the risk of infectious complications, which adversely affects neurological outcome. Among those, pneumonia affects as many as one third of stroke patients and is the main contributor to mortality in the post-acute phase of stroke. Experimental findings on post-stroke susceptibility to spontaneous pneumonia in mice are contradictory. Here, we established a mouse model inducing standardized bacterial pneumonia and characterized the impaired pulmonary cellular and humoral immune responses after experimental stroke. <b><i>Methods:</i></b> Bacterial pneumonia was induced by intra-tracheal inoculation with <i>Streptococcus pneumoniae</i> at different time points after transient middle cerebral artery occlusion (MCAO). Bacterial counts in lungs and blood, histological changes, and cytokine production in the lungs were assessed. Furthermore, we investigated the effect of pneumonia on stroke outcome. <b><i>Results:</i></b> Intra-tracheal inoculation resulted in reproducible pneumonia and bacteraemia, and demonstrated post-stroke susceptibility to streptococcal pneumonia developing with a delay of at least 24 h after MCAO. Higher bacterial counts in mice infected 3 days after stroke induction correlated with reduced neutrophil and macrophage infiltration in the lungs and lower levels of pro-inflammatory cytokines in the broncho-alveolar lavage compared to sham-operated animals. Pneumonia increased mortality without affecting brain-infiltrating leukocytes. <b><i>Conclusions:</i></b> In this standardized mouse model of post-stroke pneumonia, we describe attenuated leukocyte infiltration and cytokine production in response to bacterial infection in the lungs that has a profound effect on outcome.
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title_short	A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae
url	http://dx.doi.org/10.1159/000452136 https://www.karger.com/Article/FullText/452136
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up_date	2024-07-04T20:36:35.794Z
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A mouse model of post-stroke pneumonia induced by intra-tracheal inoculation with Streptococcus pneumoniae

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