Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion
Purpose: Due to the potentially periodic collimator dynamic in volumetric modulated arc therapy (VMAT) dose deliveries with the sweeping-window arc therapy (SWAT) technique, additional manifestations of dosimetric deviations in the presence of intrafractional motion may occur. With a fast multileaf...
Ausführliche Beschreibung
Gespeichert in:
| Autor*in: |
Fleckenstein, Jens - 1981- [verfasserIn] Hesser, Jürgen - 1964- [verfasserIn] Wenz, Frederik - 1966- [verfasserIn] Lohr, Frank [verfasserIn] |
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| Format: |
E-Artikel |
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| Sprache: |
Englisch |
| Erschienen: |
13 March 2015 |
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| Schlagwörter: |
Intensity modulated radiation therapy Measurement of nuclear or x-radiation |
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| Anmerkung: |
Gesehen am 06.11.2017 |
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| Umfang: |
8 |
| Übergeordnetes Werk: |
Enthalten in: Medical physics - Hoboken, NJ : Wiley, 1974, 42(2015), 4, Seite 1538-1545 |
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| Übergeordnetes Werk: |
volume:42 ; year:2015 ; number:4 ; pages:1538-1545 ; extent:8 |
| Links: |
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| DOI / URN: |
10.1118/1.4914166 |
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| Katalog-ID: |
1565012259 |
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| 100 | 1 | |a Fleckenstein, Jens |d 1981- |e verfasserin |0 (DE-588)102911918X |0 (DE-627)732477212 |0 (DE-576)376584599 |4 aut | |
| 245 | 1 | 0 | |a Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion |c Jens Fleckenstein, Jürgen Hesser, Frederik Wenz, and Frank Lohr |
| 264 | 1 | |c 13 March 2015 | |
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| 500 | |a Gesehen am 06.11.2017 | ||
| 520 | |a Purpose: Due to the potentially periodic collimator dynamic in volumetric modulated arc therapy (VMAT) dose deliveries with the sweeping-window arc therapy (SWAT) technique, additional manifestations of dosimetric deviations in the presence of intrafractional motion may occur. With a fast multileaf collimator (MLC), and a flattening filter free dose delivery, treatment times close to 60 s per fraction are clinical reality. For these treatment sequences, the human breathing period can be close to the collimator sweeping period. Compared to a random arrangement of the segments, this will cause a further degradation of the dose homogeneity. Methods: Fifty VMAT sequences of potentially moving target volumes were delivered on a two dimensional ionization chamber array. In order to detect interplay effects along all three coordinate axes, time resolved measurements were performed twice—with the detector aligned in vertical (V) or horizontal (H) orientation. All dose matrices were then moved within a simulation software by a time-dependent motion vector. The minimum relative equivalent uniform dose EUDr,m for all breathing starting phases was determined for each amplitude and period. Furthermore, an estimation of periods with minimum EUD was performed. Additionally, LINAC logfiles were recorded during plan delivery. The MLC, jaw, gantry angle, and monitor unit settings were continuously saved and used to calculate the correlation coefficient between the target motion and the dose weighed collimator motion component for each direction (CC, LR, AP) separately. Results: The resulting EUDr,m were EUDr,m(CCV) = (98.3 ± 0.6)%, EUDr,m(CCH) = (98.6 ± 0.5)%, EUDr,m(APV) = (97.7 ± 0.9)%, and EUDr,m(LRH) = (97.8 ± 0.9)%. The overall minimum relative EUD observed for 360∘ arc midventilation treatments was 94.6%. The treatment plan with the shortest period and a minimum relative EUD of less than 97% was found at T = 6.1 s. For a partial 120∘ arc, an EUDr,m = 92.0% was found. In all cases, a correlation coefficient above 0.5 corresponded to a minimum in EUD. Conclusions: With the advent of fast VMAT delivery techniques, nonrobust treatment sequences for human breathing patterns can be generated. These sequences are characterized by a large correlation coefficient between a target motion component and the corresponding collimator dynamic. By iteratively decreasing the maximum allowed dose rate, a low correlation coefficient and consequentially a robust treatment sequence are ensured. | ||
| 650 | 4 | |a cancer | |
| 650 | 4 | |a Collimators | |
| 650 | 4 | |a dosimetry | |
| 650 | 4 | |a Drug delivery | |
| 650 | 4 | |a Intensity modulated radiation therapy | |
| 650 | 4 | |a interplay effects | |
| 650 | 4 | |a ionisation chambers | |
| 650 | 4 | |a Linear accelerators | |
| 650 | 4 | |a Lungs | |
| 650 | 4 | |a Measurement of nuclear or x-radiation | |
| 650 | 4 | |a Medical treatment planning | |
| 650 | 4 | |a Multileaf collimators | |
| 650 | 4 | |a organ motion | |
| 650 | 4 | |a pneumodynamics | |
| 650 | 4 | |a radiation therapy | |
| 650 | 4 | |a Radiation treatment | |
| 650 | 4 | |a Real time information delivery | |
| 650 | 4 | |a robust planning | |
| 650 | 4 | |a time resolved dosimetry | |
| 650 | 4 | |a tumours | |
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| 700 | 1 | |a Wenz, Frederik |d 1966- |e verfasserin |0 (DE-588)113310390 |0 (DE-627)663837766 |0 (DE-576)346656281 |4 aut | |
| 700 | 1 | |a Lohr, Frank |e verfasserin |0 (DE-588)1025307194 |0 (DE-627)72201967X |0 (DE-576)37018694X |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Medical physics |d Hoboken, NJ : Wiley, 1974 |g 42(2015), 4, Seite 1538-1545 |h Online-Ressource |w (DE-627)265784867 |w (DE-600)1466421-5 |w (DE-576)074891243 |x 2473-4209 |7 nnns |
| 773 | 1 | 8 | |g volume:42 |g year:2015 |g number:4 |g pages:1538-1545 |g extent:8 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1118/1.4914166 |x Verlag |x Resolving-System |3 Volltext |
| 856 | 4 | 0 | |u http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1118/1.4914166/abstract |x Verlag |3 Volltext |
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10.1118/1.4914166 doi (DE-627)1565012259 (DE-576)495012254 (DE-599)BSZ495012254 (OCoLC)1340981370 DE-627 ger DE-627 rda eng Fleckenstein, Jens 1981- verfasserin (DE-588)102911918X (DE-627)732477212 (DE-576)376584599 aut Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion Jens Fleckenstein, Jürgen Hesser, Frederik Wenz, and Frank Lohr 13 March 2015 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 06.11.2017 Purpose: Due to the potentially periodic collimator dynamic in volumetric modulated arc therapy (VMAT) dose deliveries with the sweeping-window arc therapy (SWAT) technique, additional manifestations of dosimetric deviations in the presence of intrafractional motion may occur. With a fast multileaf collimator (MLC), and a flattening filter free dose delivery, treatment times close to 60 s per fraction are clinical reality. For these treatment sequences, the human breathing period can be close to the collimator sweeping period. Compared to a random arrangement of the segments, this will cause a further degradation of the dose homogeneity. Methods: Fifty VMAT sequences of potentially moving target volumes were delivered on a two dimensional ionization chamber array. In order to detect interplay effects along all three coordinate axes, time resolved measurements were performed twice—with the detector aligned in vertical (V) or horizontal (H) orientation. All dose matrices were then moved within a simulation software by a time-dependent motion vector. The minimum relative equivalent uniform dose EUDr,m for all breathing starting phases was determined for each amplitude and period. Furthermore, an estimation of periods with minimum EUD was performed. Additionally, LINAC logfiles were recorded during plan delivery. The MLC, jaw, gantry angle, and monitor unit settings were continuously saved and used to calculate the correlation coefficient between the target motion and the dose weighed collimator motion component for each direction (CC, LR, AP) separately. Results: The resulting EUDr,m were EUDr,m(CCV) = (98.3 ± 0.6)%, EUDr,m(CCH) = (98.6 ± 0.5)%, EUDr,m(APV) = (97.7 ± 0.9)%, and EUDr,m(LRH) = (97.8 ± 0.9)%. The overall minimum relative EUD observed for 360∘ arc midventilation treatments was 94.6%. The treatment plan with the shortest period and a minimum relative EUD of less than 97% was found at T = 6.1 s. For a partial 120∘ arc, an EUDr,m = 92.0% was found. In all cases, a correlation coefficient above 0.5 corresponded to a minimum in EUD. Conclusions: With the advent of fast VMAT delivery techniques, nonrobust treatment sequences for human breathing patterns can be generated. These sequences are characterized by a large correlation coefficient between a target motion component and the corresponding collimator dynamic. By iteratively decreasing the maximum allowed dose rate, a low correlation coefficient and consequentially a robust treatment sequence are ensured. cancer Collimators dosimetry Drug delivery Intensity modulated radiation therapy interplay effects ionisation chambers Linear accelerators Lungs Measurement of nuclear or x-radiation Medical treatment planning Multileaf collimators organ motion pneumodynamics radiation therapy Radiation treatment Real time information delivery robust planning time resolved dosimetry tumours Hesser, Jürgen 1964- verfasserin (DE-588)1020647353 (DE-627)691291071 (DE-576)361513739 aut Wenz, Frederik 1966- verfasserin (DE-588)113310390 (DE-627)663837766 (DE-576)346656281 aut Lohr, Frank verfasserin (DE-588)1025307194 (DE-627)72201967X (DE-576)37018694X aut Enthalten in Medical physics Hoboken, NJ : Wiley, 1974 42(2015), 4, Seite 1538-1545 Online-Ressource (DE-627)265784867 (DE-600)1466421-5 (DE-576)074891243 2473-4209 nnns volume:42 year:2015 number:4 pages:1538-1545 extent:8 http://dx.doi.org/10.1118/1.4914166 Verlag Resolving-System Volltext http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1118/1.4914166/abstract Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 42 2015 4 1538-1545 8 2013 01 DE-16-250 2986416330 00 --%%-- --%%-- --%%-- --%%-- l01 06-11-17 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_8 2013 01 DE-16-250 04 p (DE-627)1446585476 Fleckenstein, Jens 2013 01 DE-16-250 04 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1431529397 Hesser, Jürgen 2013 01 DE-16-250 05 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1440188726 Wenz, Frederik 2013 01 DE-16-250 06 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)144018853X Lohr, Frank 2013 01 DE-16-250 07 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4 |
| spelling |
10.1118/1.4914166 doi (DE-627)1565012259 (DE-576)495012254 (DE-599)BSZ495012254 (OCoLC)1340981370 DE-627 ger DE-627 rda eng Fleckenstein, Jens 1981- verfasserin (DE-588)102911918X (DE-627)732477212 (DE-576)376584599 aut Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion Jens Fleckenstein, Jürgen Hesser, Frederik Wenz, and Frank Lohr 13 March 2015 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 06.11.2017 Purpose: Due to the potentially periodic collimator dynamic in volumetric modulated arc therapy (VMAT) dose deliveries with the sweeping-window arc therapy (SWAT) technique, additional manifestations of dosimetric deviations in the presence of intrafractional motion may occur. With a fast multileaf collimator (MLC), and a flattening filter free dose delivery, treatment times close to 60 s per fraction are clinical reality. For these treatment sequences, the human breathing period can be close to the collimator sweeping period. Compared to a random arrangement of the segments, this will cause a further degradation of the dose homogeneity. Methods: Fifty VMAT sequences of potentially moving target volumes were delivered on a two dimensional ionization chamber array. In order to detect interplay effects along all three coordinate axes, time resolved measurements were performed twice—with the detector aligned in vertical (V) or horizontal (H) orientation. All dose matrices were then moved within a simulation software by a time-dependent motion vector. The minimum relative equivalent uniform dose EUDr,m for all breathing starting phases was determined for each amplitude and period. Furthermore, an estimation of periods with minimum EUD was performed. Additionally, LINAC logfiles were recorded during plan delivery. The MLC, jaw, gantry angle, and monitor unit settings were continuously saved and used to calculate the correlation coefficient between the target motion and the dose weighed collimator motion component for each direction (CC, LR, AP) separately. Results: The resulting EUDr,m were EUDr,m(CCV) = (98.3 ± 0.6)%, EUDr,m(CCH) = (98.6 ± 0.5)%, EUDr,m(APV) = (97.7 ± 0.9)%, and EUDr,m(LRH) = (97.8 ± 0.9)%. The overall minimum relative EUD observed for 360∘ arc midventilation treatments was 94.6%. The treatment plan with the shortest period and a minimum relative EUD of less than 97% was found at T = 6.1 s. For a partial 120∘ arc, an EUDr,m = 92.0% was found. In all cases, a correlation coefficient above 0.5 corresponded to a minimum in EUD. Conclusions: With the advent of fast VMAT delivery techniques, nonrobust treatment sequences for human breathing patterns can be generated. These sequences are characterized by a large correlation coefficient between a target motion component and the corresponding collimator dynamic. By iteratively decreasing the maximum allowed dose rate, a low correlation coefficient and consequentially a robust treatment sequence are ensured. cancer Collimators dosimetry Drug delivery Intensity modulated radiation therapy interplay effects ionisation chambers Linear accelerators Lungs Measurement of nuclear or x-radiation Medical treatment planning Multileaf collimators organ motion pneumodynamics radiation therapy Radiation treatment Real time information delivery robust planning time resolved dosimetry tumours Hesser, Jürgen 1964- verfasserin (DE-588)1020647353 (DE-627)691291071 (DE-576)361513739 aut Wenz, Frederik 1966- verfasserin (DE-588)113310390 (DE-627)663837766 (DE-576)346656281 aut Lohr, Frank verfasserin (DE-588)1025307194 (DE-627)72201967X (DE-576)37018694X aut Enthalten in Medical physics Hoboken, NJ : Wiley, 1974 42(2015), 4, Seite 1538-1545 Online-Ressource (DE-627)265784867 (DE-600)1466421-5 (DE-576)074891243 2473-4209 nnns volume:42 year:2015 number:4 pages:1538-1545 extent:8 http://dx.doi.org/10.1118/1.4914166 Verlag Resolving-System Volltext http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1118/1.4914166/abstract Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 42 2015 4 1538-1545 8 2013 01 DE-16-250 2986416330 00 --%%-- --%%-- --%%-- --%%-- l01 06-11-17 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_8 2013 01 DE-16-250 04 p (DE-627)1446585476 Fleckenstein, Jens 2013 01 DE-16-250 04 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1431529397 Hesser, Jürgen 2013 01 DE-16-250 05 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1440188726 Wenz, Frederik 2013 01 DE-16-250 06 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)144018853X Lohr, Frank 2013 01 DE-16-250 07 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4 |
| allfields_unstemmed |
10.1118/1.4914166 doi (DE-627)1565012259 (DE-576)495012254 (DE-599)BSZ495012254 (OCoLC)1340981370 DE-627 ger DE-627 rda eng Fleckenstein, Jens 1981- verfasserin (DE-588)102911918X (DE-627)732477212 (DE-576)376584599 aut Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion Jens Fleckenstein, Jürgen Hesser, Frederik Wenz, and Frank Lohr 13 March 2015 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 06.11.2017 Purpose: Due to the potentially periodic collimator dynamic in volumetric modulated arc therapy (VMAT) dose deliveries with the sweeping-window arc therapy (SWAT) technique, additional manifestations of dosimetric deviations in the presence of intrafractional motion may occur. With a fast multileaf collimator (MLC), and a flattening filter free dose delivery, treatment times close to 60 s per fraction are clinical reality. For these treatment sequences, the human breathing period can be close to the collimator sweeping period. Compared to a random arrangement of the segments, this will cause a further degradation of the dose homogeneity. Methods: Fifty VMAT sequences of potentially moving target volumes were delivered on a two dimensional ionization chamber array. In order to detect interplay effects along all three coordinate axes, time resolved measurements were performed twice—with the detector aligned in vertical (V) or horizontal (H) orientation. All dose matrices were then moved within a simulation software by a time-dependent motion vector. The minimum relative equivalent uniform dose EUDr,m for all breathing starting phases was determined for each amplitude and period. Furthermore, an estimation of periods with minimum EUD was performed. Additionally, LINAC logfiles were recorded during plan delivery. The MLC, jaw, gantry angle, and monitor unit settings were continuously saved and used to calculate the correlation coefficient between the target motion and the dose weighed collimator motion component for each direction (CC, LR, AP) separately. Results: The resulting EUDr,m were EUDr,m(CCV) = (98.3 ± 0.6)%, EUDr,m(CCH) = (98.6 ± 0.5)%, EUDr,m(APV) = (97.7 ± 0.9)%, and EUDr,m(LRH) = (97.8 ± 0.9)%. The overall minimum relative EUD observed for 360∘ arc midventilation treatments was 94.6%. The treatment plan with the shortest period and a minimum relative EUD of less than 97% was found at T = 6.1 s. For a partial 120∘ arc, an EUDr,m = 92.0% was found. In all cases, a correlation coefficient above 0.5 corresponded to a minimum in EUD. Conclusions: With the advent of fast VMAT delivery techniques, nonrobust treatment sequences for human breathing patterns can be generated. These sequences are characterized by a large correlation coefficient between a target motion component and the corresponding collimator dynamic. By iteratively decreasing the maximum allowed dose rate, a low correlation coefficient and consequentially a robust treatment sequence are ensured. cancer Collimators dosimetry Drug delivery Intensity modulated radiation therapy interplay effects ionisation chambers Linear accelerators Lungs Measurement of nuclear or x-radiation Medical treatment planning Multileaf collimators organ motion pneumodynamics radiation therapy Radiation treatment Real time information delivery robust planning time resolved dosimetry tumours Hesser, Jürgen 1964- verfasserin (DE-588)1020647353 (DE-627)691291071 (DE-576)361513739 aut Wenz, Frederik 1966- verfasserin (DE-588)113310390 (DE-627)663837766 (DE-576)346656281 aut Lohr, Frank verfasserin (DE-588)1025307194 (DE-627)72201967X (DE-576)37018694X aut Enthalten in Medical physics Hoboken, NJ : Wiley, 1974 42(2015), 4, Seite 1538-1545 Online-Ressource (DE-627)265784867 (DE-600)1466421-5 (DE-576)074891243 2473-4209 nnns volume:42 year:2015 number:4 pages:1538-1545 extent:8 http://dx.doi.org/10.1118/1.4914166 Verlag Resolving-System Volltext http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1118/1.4914166/abstract Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 42 2015 4 1538-1545 8 2013 01 DE-16-250 2986416330 00 --%%-- --%%-- --%%-- --%%-- l01 06-11-17 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_8 2013 01 DE-16-250 04 p (DE-627)1446585476 Fleckenstein, Jens 2013 01 DE-16-250 04 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1431529397 Hesser, Jürgen 2013 01 DE-16-250 05 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1440188726 Wenz, Frederik 2013 01 DE-16-250 06 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)144018853X Lohr, Frank 2013 01 DE-16-250 07 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4 |
| allfieldsGer |
10.1118/1.4914166 doi (DE-627)1565012259 (DE-576)495012254 (DE-599)BSZ495012254 (OCoLC)1340981370 DE-627 ger DE-627 rda eng Fleckenstein, Jens 1981- verfasserin (DE-588)102911918X (DE-627)732477212 (DE-576)376584599 aut Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion Jens Fleckenstein, Jürgen Hesser, Frederik Wenz, and Frank Lohr 13 March 2015 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 06.11.2017 Purpose: Due to the potentially periodic collimator dynamic in volumetric modulated arc therapy (VMAT) dose deliveries with the sweeping-window arc therapy (SWAT) technique, additional manifestations of dosimetric deviations in the presence of intrafractional motion may occur. With a fast multileaf collimator (MLC), and a flattening filter free dose delivery, treatment times close to 60 s per fraction are clinical reality. For these treatment sequences, the human breathing period can be close to the collimator sweeping period. Compared to a random arrangement of the segments, this will cause a further degradation of the dose homogeneity. Methods: Fifty VMAT sequences of potentially moving target volumes were delivered on a two dimensional ionization chamber array. In order to detect interplay effects along all three coordinate axes, time resolved measurements were performed twice—with the detector aligned in vertical (V) or horizontal (H) orientation. All dose matrices were then moved within a simulation software by a time-dependent motion vector. The minimum relative equivalent uniform dose EUDr,m for all breathing starting phases was determined for each amplitude and period. Furthermore, an estimation of periods with minimum EUD was performed. Additionally, LINAC logfiles were recorded during plan delivery. The MLC, jaw, gantry angle, and monitor unit settings were continuously saved and used to calculate the correlation coefficient between the target motion and the dose weighed collimator motion component for each direction (CC, LR, AP) separately. Results: The resulting EUDr,m were EUDr,m(CCV) = (98.3 ± 0.6)%, EUDr,m(CCH) = (98.6 ± 0.5)%, EUDr,m(APV) = (97.7 ± 0.9)%, and EUDr,m(LRH) = (97.8 ± 0.9)%. The overall minimum relative EUD observed for 360∘ arc midventilation treatments was 94.6%. The treatment plan with the shortest period and a minimum relative EUD of less than 97% was found at T = 6.1 s. For a partial 120∘ arc, an EUDr,m = 92.0% was found. In all cases, a correlation coefficient above 0.5 corresponded to a minimum in EUD. Conclusions: With the advent of fast VMAT delivery techniques, nonrobust treatment sequences for human breathing patterns can be generated. These sequences are characterized by a large correlation coefficient between a target motion component and the corresponding collimator dynamic. By iteratively decreasing the maximum allowed dose rate, a low correlation coefficient and consequentially a robust treatment sequence are ensured. cancer Collimators dosimetry Drug delivery Intensity modulated radiation therapy interplay effects ionisation chambers Linear accelerators Lungs Measurement of nuclear or x-radiation Medical treatment planning Multileaf collimators organ motion pneumodynamics radiation therapy Radiation treatment Real time information delivery robust planning time resolved dosimetry tumours Hesser, Jürgen 1964- verfasserin (DE-588)1020647353 (DE-627)691291071 (DE-576)361513739 aut Wenz, Frederik 1966- verfasserin (DE-588)113310390 (DE-627)663837766 (DE-576)346656281 aut Lohr, Frank verfasserin (DE-588)1025307194 (DE-627)72201967X (DE-576)37018694X aut Enthalten in Medical physics Hoboken, NJ : Wiley, 1974 42(2015), 4, Seite 1538-1545 Online-Ressource (DE-627)265784867 (DE-600)1466421-5 (DE-576)074891243 2473-4209 nnns volume:42 year:2015 number:4 pages:1538-1545 extent:8 http://dx.doi.org/10.1118/1.4914166 Verlag Resolving-System Volltext http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1118/1.4914166/abstract Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 42 2015 4 1538-1545 8 2013 01 DE-16-250 2986416330 00 --%%-- --%%-- --%%-- --%%-- l01 06-11-17 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_8 2013 01 DE-16-250 04 p (DE-627)1446585476 Fleckenstein, Jens 2013 01 DE-16-250 04 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1431529397 Hesser, Jürgen 2013 01 DE-16-250 05 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1440188726 Wenz, Frederik 2013 01 DE-16-250 06 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)144018853X Lohr, Frank 2013 01 DE-16-250 07 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4 |
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10.1118/1.4914166 doi (DE-627)1565012259 (DE-576)495012254 (DE-599)BSZ495012254 (OCoLC)1340981370 DE-627 ger DE-627 rda eng Fleckenstein, Jens 1981- verfasserin (DE-588)102911918X (DE-627)732477212 (DE-576)376584599 aut Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion Jens Fleckenstein, Jürgen Hesser, Frederik Wenz, and Frank Lohr 13 March 2015 8 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 06.11.2017 Purpose: Due to the potentially periodic collimator dynamic in volumetric modulated arc therapy (VMAT) dose deliveries with the sweeping-window arc therapy (SWAT) technique, additional manifestations of dosimetric deviations in the presence of intrafractional motion may occur. With a fast multileaf collimator (MLC), and a flattening filter free dose delivery, treatment times close to 60 s per fraction are clinical reality. For these treatment sequences, the human breathing period can be close to the collimator sweeping period. Compared to a random arrangement of the segments, this will cause a further degradation of the dose homogeneity. Methods: Fifty VMAT sequences of potentially moving target volumes were delivered on a two dimensional ionization chamber array. In order to detect interplay effects along all three coordinate axes, time resolved measurements were performed twice—with the detector aligned in vertical (V) or horizontal (H) orientation. All dose matrices were then moved within a simulation software by a time-dependent motion vector. The minimum relative equivalent uniform dose EUDr,m for all breathing starting phases was determined for each amplitude and period. Furthermore, an estimation of periods with minimum EUD was performed. Additionally, LINAC logfiles were recorded during plan delivery. The MLC, jaw, gantry angle, and monitor unit settings were continuously saved and used to calculate the correlation coefficient between the target motion and the dose weighed collimator motion component for each direction (CC, LR, AP) separately. Results: The resulting EUDr,m were EUDr,m(CCV) = (98.3 ± 0.6)%, EUDr,m(CCH) = (98.6 ± 0.5)%, EUDr,m(APV) = (97.7 ± 0.9)%, and EUDr,m(LRH) = (97.8 ± 0.9)%. The overall minimum relative EUD observed for 360∘ arc midventilation treatments was 94.6%. The treatment plan with the shortest period and a minimum relative EUD of less than 97% was found at T = 6.1 s. For a partial 120∘ arc, an EUDr,m = 92.0% was found. In all cases, a correlation coefficient above 0.5 corresponded to a minimum in EUD. Conclusions: With the advent of fast VMAT delivery techniques, nonrobust treatment sequences for human breathing patterns can be generated. These sequences are characterized by a large correlation coefficient between a target motion component and the corresponding collimator dynamic. By iteratively decreasing the maximum allowed dose rate, a low correlation coefficient and consequentially a robust treatment sequence are ensured. cancer Collimators dosimetry Drug delivery Intensity modulated radiation therapy interplay effects ionisation chambers Linear accelerators Lungs Measurement of nuclear or x-radiation Medical treatment planning Multileaf collimators organ motion pneumodynamics radiation therapy Radiation treatment Real time information delivery robust planning time resolved dosimetry tumours Hesser, Jürgen 1964- verfasserin (DE-588)1020647353 (DE-627)691291071 (DE-576)361513739 aut Wenz, Frederik 1966- verfasserin (DE-588)113310390 (DE-627)663837766 (DE-576)346656281 aut Lohr, Frank verfasserin (DE-588)1025307194 (DE-627)72201967X (DE-576)37018694X aut Enthalten in Medical physics Hoboken, NJ : Wiley, 1974 42(2015), 4, Seite 1538-1545 Online-Ressource (DE-627)265784867 (DE-600)1466421-5 (DE-576)074891243 2473-4209 nnns volume:42 year:2015 number:4 pages:1538-1545 extent:8 http://dx.doi.org/10.1118/1.4914166 Verlag Resolving-System Volltext http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1118/1.4914166/abstract Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4393 GBV_ILN_4700 AR 42 2015 4 1538-1545 8 2013 01 DE-16-250 2986416330 00 --%%-- --%%-- --%%-- --%%-- l01 06-11-17 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_4 2013 01 DE-16-250 03 s s_8 2013 01 DE-16-250 04 p (DE-627)1446585476 Fleckenstein, Jens 2013 01 DE-16-250 04 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1431529397 Hesser, Jürgen 2013 01 DE-16-250 05 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_2 2013 01 DE-16-250 06 p (DE-627)1440188726 Wenz, Frederik 2013 01 DE-16-250 06 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_3 2013 01 DE-16-250 07 p (DE-627)144018853X Lohr, Frank 2013 01 DE-16-250 07 k (DE-627)1426595115 Klinik für Strahlentherapie und Radioonkologie 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_4 |
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| standort_str_mv |
--%%-- |
| standort_iln_str_mv |
2013:--%%-- DE-16-250:--%%-- |
| author |
Fleckenstein, Jens 1981- |
| spellingShingle |
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Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion |
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Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion Jens Fleckenstein, Jürgen Hesser, Frederik Wenz, and Frank Lohr |
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robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion |
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Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion |
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Purpose: Due to the potentially periodic collimator dynamic in volumetric modulated arc therapy (VMAT) dose deliveries with the sweeping-window arc therapy (SWAT) technique, additional manifestations of dosimetric deviations in the presence of intrafractional motion may occur. With a fast multileaf collimator (MLC), and a flattening filter free dose delivery, treatment times close to 60 s per fraction are clinical reality. For these treatment sequences, the human breathing period can be close to the collimator sweeping period. Compared to a random arrangement of the segments, this will cause a further degradation of the dose homogeneity. Methods: Fifty VMAT sequences of potentially moving target volumes were delivered on a two dimensional ionization chamber array. In order to detect interplay effects along all three coordinate axes, time resolved measurements were performed twice—with the detector aligned in vertical (V) or horizontal (H) orientation. All dose matrices were then moved within a simulation software by a time-dependent motion vector. The minimum relative equivalent uniform dose EUDr,m for all breathing starting phases was determined for each amplitude and period. Furthermore, an estimation of periods with minimum EUD was performed. Additionally, LINAC logfiles were recorded during plan delivery. The MLC, jaw, gantry angle, and monitor unit settings were continuously saved and used to calculate the correlation coefficient between the target motion and the dose weighed collimator motion component for each direction (CC, LR, AP) separately. Results: The resulting EUDr,m were EUDr,m(CCV) = (98.3 ± 0.6)%, EUDr,m(CCH) = (98.6 ± 0.5)%, EUDr,m(APV) = (97.7 ± 0.9)%, and EUDr,m(LRH) = (97.8 ± 0.9)%. The overall minimum relative EUD observed for 360∘ arc midventilation treatments was 94.6%. The treatment plan with the shortest period and a minimum relative EUD of less than 97% was found at T = 6.1 s. For a partial 120∘ arc, an EUDr,m = 92.0% was found. In all cases, a correlation coefficient above 0.5 corresponded to a minimum in EUD. Conclusions: With the advent of fast VMAT delivery techniques, nonrobust treatment sequences for human breathing patterns can be generated. These sequences are characterized by a large correlation coefficient between a target motion component and the corresponding collimator dynamic. By iteratively decreasing the maximum allowed dose rate, a low correlation coefficient and consequentially a robust treatment sequence are ensured. Gesehen am 06.11.2017 |
| abstractGer |
Purpose: Due to the potentially periodic collimator dynamic in volumetric modulated arc therapy (VMAT) dose deliveries with the sweeping-window arc therapy (SWAT) technique, additional manifestations of dosimetric deviations in the presence of intrafractional motion may occur. With a fast multileaf collimator (MLC), and a flattening filter free dose delivery, treatment times close to 60 s per fraction are clinical reality. For these treatment sequences, the human breathing period can be close to the collimator sweeping period. Compared to a random arrangement of the segments, this will cause a further degradation of the dose homogeneity. Methods: Fifty VMAT sequences of potentially moving target volumes were delivered on a two dimensional ionization chamber array. In order to detect interplay effects along all three coordinate axes, time resolved measurements were performed twice—with the detector aligned in vertical (V) or horizontal (H) orientation. All dose matrices were then moved within a simulation software by a time-dependent motion vector. The minimum relative equivalent uniform dose EUDr,m for all breathing starting phases was determined for each amplitude and period. Furthermore, an estimation of periods with minimum EUD was performed. Additionally, LINAC logfiles were recorded during plan delivery. The MLC, jaw, gantry angle, and monitor unit settings were continuously saved and used to calculate the correlation coefficient between the target motion and the dose weighed collimator motion component for each direction (CC, LR, AP) separately. Results: The resulting EUDr,m were EUDr,m(CCV) = (98.3 ± 0.6)%, EUDr,m(CCH) = (98.6 ± 0.5)%, EUDr,m(APV) = (97.7 ± 0.9)%, and EUDr,m(LRH) = (97.8 ± 0.9)%. The overall minimum relative EUD observed for 360∘ arc midventilation treatments was 94.6%. The treatment plan with the shortest period and a minimum relative EUD of less than 97% was found at T = 6.1 s. For a partial 120∘ arc, an EUDr,m = 92.0% was found. In all cases, a correlation coefficient above 0.5 corresponded to a minimum in EUD. Conclusions: With the advent of fast VMAT delivery techniques, nonrobust treatment sequences for human breathing patterns can be generated. These sequences are characterized by a large correlation coefficient between a target motion component and the corresponding collimator dynamic. By iteratively decreasing the maximum allowed dose rate, a low correlation coefficient and consequentially a robust treatment sequence are ensured. Gesehen am 06.11.2017 |
| abstract_unstemmed |
Purpose: Due to the potentially periodic collimator dynamic in volumetric modulated arc therapy (VMAT) dose deliveries with the sweeping-window arc therapy (SWAT) technique, additional manifestations of dosimetric deviations in the presence of intrafractional motion may occur. With a fast multileaf collimator (MLC), and a flattening filter free dose delivery, treatment times close to 60 s per fraction are clinical reality. For these treatment sequences, the human breathing period can be close to the collimator sweeping period. Compared to a random arrangement of the segments, this will cause a further degradation of the dose homogeneity. Methods: Fifty VMAT sequences of potentially moving target volumes were delivered on a two dimensional ionization chamber array. In order to detect interplay effects along all three coordinate axes, time resolved measurements were performed twice—with the detector aligned in vertical (V) or horizontal (H) orientation. All dose matrices were then moved within a simulation software by a time-dependent motion vector. The minimum relative equivalent uniform dose EUDr,m for all breathing starting phases was determined for each amplitude and period. Furthermore, an estimation of periods with minimum EUD was performed. Additionally, LINAC logfiles were recorded during plan delivery. The MLC, jaw, gantry angle, and monitor unit settings were continuously saved and used to calculate the correlation coefficient between the target motion and the dose weighed collimator motion component for each direction (CC, LR, AP) separately. Results: The resulting EUDr,m were EUDr,m(CCV) = (98.3 ± 0.6)%, EUDr,m(CCH) = (98.6 ± 0.5)%, EUDr,m(APV) = (97.7 ± 0.9)%, and EUDr,m(LRH) = (97.8 ± 0.9)%. The overall minimum relative EUD observed for 360∘ arc midventilation treatments was 94.6%. The treatment plan with the shortest period and a minimum relative EUD of less than 97% was found at T = 6.1 s. For a partial 120∘ arc, an EUDr,m = 92.0% was found. In all cases, a correlation coefficient above 0.5 corresponded to a minimum in EUD. Conclusions: With the advent of fast VMAT delivery techniques, nonrobust treatment sequences for human breathing patterns can be generated. These sequences are characterized by a large correlation coefficient between a target motion component and the corresponding collimator dynamic. By iteratively decreasing the maximum allowed dose rate, a low correlation coefficient and consequentially a robust treatment sequence are ensured. Gesehen am 06.11.2017 |
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Robustness of sweeping-window arc therapy treatment sequences against intrafractional tumor motion |
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