KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance

Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (...
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Gespeichert in:

Autor*in:	Schwaab, Juliana - 1982- [verfasserIn] Metzgeroth, Georgia - 1972- [verfasserIn] Naumann, Nicole - 1988- [verfasserIn] Jawhar, Mohamad - 1986- [verfasserIn] Gaiser, Timo - 1975- [verfasserIn] Hofmann, Wolf-Karsten - 1967- [verfasserIn] Fabarius, Alice - 1965- [verfasserIn] Reiter, Andreas - 1964- [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	28 May 2015

Anmerkung:	Gesehen am 08.03.2018
Umfang:	4

Übergeordnetes Werk:	Enthalten in: American journal of hematology - New York, NY : Wiley-Liss, 1976, 90(2015), 9, Seite 774-777
Übergeordnetes Werk:	volume:90 ; year:2015 ; number:9 ; pages:774-777 ; extent:4

Links:	Volltext Volltext

DOI / URN:	10.1002/ajh.24075

Katalog-ID:	1570654603

Internformat


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100	1		\|a Schwaab, Juliana \|d 1982- \|e verfasserin \|0 (DE-588)1051912687 \|0 (DE-627)787019399 \|0 (DE-576)407558764 \|4 aut
245	1	0	\|a KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance \|c Juliana Schwaab, Roland Umbach, Georgia Metzgeroth, Nicole Naumann, Mohamad Jawhar, Karl Sotlar, Hans-Peter Horny, Timo Gaiser, Wolf-Karsten Hofmann, Susanne Schnittger, Nicholas C.P. Cross, Alice Fabarius, and Andreas Reiter
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520			\|a Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (FP) fusion gene also for KIT D816V and JAK2 V617F mutations. Overall, 86 (20%) patients tested positive: FP+ in 55 (12%), KIT D816V+ in 14 (3%), and JAK2 V617F+ in 17 (4%) patients, respectively. To gain better insight into clinical characteristics, we compared these cases with 31 additional and well-characterized KIT D816V+ eosinophilia-associated systemic mastocytosis (SM-eo) patients enrolled within the “German Registry on Disorders of Eosinophils and Mast cells.” Significant differences included younger age, male predominance, and higher eosinophil counts for FP+ cases while abdominal lymphadenopathy, ascites, and serum tryptase levels >100 μg/l were characteristic for those with KIT D816V. Leukocytes, hemoglobin, and splenomegaly did not differ significantly. A median of three additional mutations, most frequently TET2 and SRSF2, were identified in 12/13 KIT D816V+ SM-eo patients with available material indicating a more complex molecular pathogenesis. Median survival was not reached for FP+ cases but was only 26 and 41 months for KIT D816V+ SM and JAK2 V617F+ MPN-eo, respectively. Eosinophilia of ≥2 × 109/l was identified as discriminator for inferior survival in KIT D816V+ and/or JAK2 V617F+ patients (median survival 20 months vs. not reached, P = 0.002). Thus, there is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia.
700	1		\|a Metzgeroth, Georgia \|d 1972- \|e verfasserin \|0 (DE-588)1051897661 \|0 (DE-627)786986832 \|0 (DE-576)407534075 \|4 aut
700	1		\|a Naumann, Nicole \|d 1988- \|e verfasserin \|0 (DE-588)1138951838 \|0 (DE-627)896569624 \|0 (DE-576)49279314X \|4 aut
700	1		\|a Jawhar, Mohamad \|d 1986- \|e verfasserin \|0 (DE-588)1046172905 \|0 (DE-627)775847747 \|0 (DE-576)399437061 \|4 aut
700	1		\|a Gaiser, Timo \|d 1975- \|e verfasserin \|0 (DE-588)1030402280 \|0 (DE-627)735221685 \|0 (DE-576)378226533 \|4 aut
700	1		\|a Hofmann, Wolf-Karsten \|d 1967- \|e verfasserin \|0 (DE-588)114154635 \|0 (DE-627)691208751 \|0 (DE-576)351568336 \|4 aut
700	1		\|a Fabarius, Alice \|d 1965- \|e verfasserin \|0 (DE-588)1037001281 \|0 (DE-627)751728314 \|0 (DE-576)390896667 \|4 aut
700	1		\|a Reiter, Andreas \|d 1964- \|e verfasserin \|0 (DE-588)172629551 \|0 (DE-627)697563766 \|0 (DE-576)133488594 \|4 aut
773	0	8	\|i Enthalten in \|t American journal of hematology \|d New York, NY : Wiley-Liss, 1976 \|g 90(2015), 9, Seite 774-777 \|h Online-Ressource \|w (DE-627)302923349 \|w (DE-600)1492749-4 \|w (DE-576)094060002 \|x 1096-8652 \|7 nnns
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912			\|a GBV_ILN_4249
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982			\|2 2013 \|1 01 \|x DE-16-250 \|8 10 \|s k \|0 (DE-627)1416468528 \|a III. Medizinische Klinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 10 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 10 \|s s \|a pos_12
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s p \|0 (DE-627)1446321282 \|a Reiter, Andreas
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s k \|0 (DE-627)1416468528 \|a III. Medizinische Klinik
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s s \|0 (DE-627)1410501914 \|a Verfasser
982			\|2 2013 \|1 01 \|x DE-16-250 \|8 11 \|s s \|a pos_13

Indexfelder

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matchkey_str	article:10968652:2015----::id1vnjkv1fuainaeeneurnlihproioh
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hierarchy_sort_str	28 May 2015
publishDate	2015
allfields	10.1002/ajh.24075 doi (DE-627)1570654603 (DE-576)500654603 (DE-599)BSZ500654603 (OCoLC)1340994060 DE-627 ger DE-627 rda eng Schwaab, Juliana 1982- verfasserin (DE-588)1051912687 (DE-627)787019399 (DE-576)407558764 aut KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance Juliana Schwaab, Roland Umbach, Georgia Metzgeroth, Nicole Naumann, Mohamad Jawhar, Karl Sotlar, Hans-Peter Horny, Timo Gaiser, Wolf-Karsten Hofmann, Susanne Schnittger, Nicholas C.P. Cross, Alice Fabarius, and Andreas Reiter 28 May 2015 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 08.03.2018 Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (FP) fusion gene also for KIT D816V and JAK2 V617F mutations. Overall, 86 (20%) patients tested positive: FP+ in 55 (12%), KIT D816V+ in 14 (3%), and JAK2 V617F+ in 17 (4%) patients, respectively. To gain better insight into clinical characteristics, we compared these cases with 31 additional and well-characterized KIT D816V+ eosinophilia-associated systemic mastocytosis (SM-eo) patients enrolled within the “German Registry on Disorders of Eosinophils and Mast cells.” Significant differences included younger age, male predominance, and higher eosinophil counts for FP+ cases while abdominal lymphadenopathy, ascites, and serum tryptase levels >100 μg/l were characteristic for those with KIT D816V. Leukocytes, hemoglobin, and splenomegaly did not differ significantly. A median of three additional mutations, most frequently TET2 and SRSF2, were identified in 12/13 KIT D816V+ SM-eo patients with available material indicating a more complex molecular pathogenesis. Median survival was not reached for FP+ cases but was only 26 and 41 months for KIT D816V+ SM and JAK2 V617F+ MPN-eo, respectively. Eosinophilia of ≥2 × 109/l was identified as discriminator for inferior survival in KIT D816V+ and/or JAK2 V617F+ patients (median survival 20 months vs. not reached, P = 0.002). Thus, there is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia. Metzgeroth, Georgia 1972- verfasserin (DE-588)1051897661 (DE-627)786986832 (DE-576)407534075 aut Naumann, Nicole 1988- verfasserin (DE-588)1138951838 (DE-627)896569624 (DE-576)49279314X aut Jawhar, Mohamad 1986- verfasserin (DE-588)1046172905 (DE-627)775847747 (DE-576)399437061 aut Gaiser, Timo 1975- verfasserin (DE-588)1030402280 (DE-627)735221685 (DE-576)378226533 aut Hofmann, Wolf-Karsten 1967- verfasserin (DE-588)114154635 (DE-627)691208751 (DE-576)351568336 aut Fabarius, Alice 1965- verfasserin (DE-588)1037001281 (DE-627)751728314 (DE-576)390896667 aut Reiter, Andreas 1964- verfasserin (DE-588)172629551 (DE-627)697563766 (DE-576)133488594 aut Enthalten in American journal of hematology New York, NY : Wiley-Liss, 1976 90(2015), 9, Seite 774-777 Online-Ressource (DE-627)302923349 (DE-600)1492749-4 (DE-576)094060002 1096-8652 nnns volume:90 year:2015 number:9 pages:774-777 extent:4 http://dx.doi.org/10.1002/ajh.24075 Verlag Resolving-System teilw. kostenfrei Volltext http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/ajh.24075/abstract Verlag teilw. kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 90 2015 9 774-777 4 2013 01 DE-16-250 3002130044 00 --%%-- --%%-- --%%-- --%%-- l01 08-03-18 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_13 2013 01 DE-16-250 03 s s_4 2013 01 DE-16-250 04 p (DE-627)1477558896 Schwaab, Juliana 2013 01 DE-16-250 04 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1477558845 Metzgeroth, Georgia 2013 01 DE-16-250 05 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_3 2013 01 DE-16-250 06 p (DE-627)1562793470 Naumann, Nicole 2013 01 DE-16-250 06 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1482083817 Jawhar, Mohamad 2013 01 DE-16-250 07 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_5 2013 01 DE-16-250 08 p (DE-627)1448227135 Gaiser, Timo 2013 01 DE-16-250 08 k (DE-627)141646882X Pathologisches Institut 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1448669421 Hofmann, Wolf-Karsten 2013 01 DE-16-250 09 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_9 2013 01 DE-16-250 10 p (DE-627)1460939530 Fabarius, Alice 2013 01 DE-16-250 10 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_12 2013 01 DE-16-250 11 p (DE-627)1446321282 Reiter, Andreas 2013 01 DE-16-250 11 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_13
spelling	10.1002/ajh.24075 doi (DE-627)1570654603 (DE-576)500654603 (DE-599)BSZ500654603 (OCoLC)1340994060 DE-627 ger DE-627 rda eng Schwaab, Juliana 1982- verfasserin (DE-588)1051912687 (DE-627)787019399 (DE-576)407558764 aut KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance Juliana Schwaab, Roland Umbach, Georgia Metzgeroth, Nicole Naumann, Mohamad Jawhar, Karl Sotlar, Hans-Peter Horny, Timo Gaiser, Wolf-Karsten Hofmann, Susanne Schnittger, Nicholas C.P. Cross, Alice Fabarius, and Andreas Reiter 28 May 2015 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 08.03.2018 Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (FP) fusion gene also for KIT D816V and JAK2 V617F mutations. Overall, 86 (20%) patients tested positive: FP+ in 55 (12%), KIT D816V+ in 14 (3%), and JAK2 V617F+ in 17 (4%) patients, respectively. To gain better insight into clinical characteristics, we compared these cases with 31 additional and well-characterized KIT D816V+ eosinophilia-associated systemic mastocytosis (SM-eo) patients enrolled within the “German Registry on Disorders of Eosinophils and Mast cells.” Significant differences included younger age, male predominance, and higher eosinophil counts for FP+ cases while abdominal lymphadenopathy, ascites, and serum tryptase levels >100 μg/l were characteristic for those with KIT D816V. Leukocytes, hemoglobin, and splenomegaly did not differ significantly. A median of three additional mutations, most frequently TET2 and SRSF2, were identified in 12/13 KIT D816V+ SM-eo patients with available material indicating a more complex molecular pathogenesis. Median survival was not reached for FP+ cases but was only 26 and 41 months for KIT D816V+ SM and JAK2 V617F+ MPN-eo, respectively. Eosinophilia of ≥2 × 109/l was identified as discriminator for inferior survival in KIT D816V+ and/or JAK2 V617F+ patients (median survival 20 months vs. not reached, P = 0.002). Thus, there is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia. Metzgeroth, Georgia 1972- verfasserin (DE-588)1051897661 (DE-627)786986832 (DE-576)407534075 aut Naumann, Nicole 1988- verfasserin (DE-588)1138951838 (DE-627)896569624 (DE-576)49279314X aut Jawhar, Mohamad 1986- verfasserin (DE-588)1046172905 (DE-627)775847747 (DE-576)399437061 aut Gaiser, Timo 1975- verfasserin (DE-588)1030402280 (DE-627)735221685 (DE-576)378226533 aut Hofmann, Wolf-Karsten 1967- verfasserin (DE-588)114154635 (DE-627)691208751 (DE-576)351568336 aut Fabarius, Alice 1965- verfasserin (DE-588)1037001281 (DE-627)751728314 (DE-576)390896667 aut Reiter, Andreas 1964- verfasserin (DE-588)172629551 (DE-627)697563766 (DE-576)133488594 aut Enthalten in American journal of hematology New York, NY : Wiley-Liss, 1976 90(2015), 9, Seite 774-777 Online-Ressource (DE-627)302923349 (DE-600)1492749-4 (DE-576)094060002 1096-8652 nnns volume:90 year:2015 number:9 pages:774-777 extent:4 http://dx.doi.org/10.1002/ajh.24075 Verlag Resolving-System teilw. kostenfrei Volltext http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/ajh.24075/abstract Verlag teilw. kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 90 2015 9 774-777 4 2013 01 DE-16-250 3002130044 00 --%%-- --%%-- --%%-- --%%-- l01 08-03-18 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_13 2013 01 DE-16-250 03 s s_4 2013 01 DE-16-250 04 p (DE-627)1477558896 Schwaab, Juliana 2013 01 DE-16-250 04 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1477558845 Metzgeroth, Georgia 2013 01 DE-16-250 05 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_3 2013 01 DE-16-250 06 p (DE-627)1562793470 Naumann, Nicole 2013 01 DE-16-250 06 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1482083817 Jawhar, Mohamad 2013 01 DE-16-250 07 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_5 2013 01 DE-16-250 08 p (DE-627)1448227135 Gaiser, Timo 2013 01 DE-16-250 08 k (DE-627)141646882X Pathologisches Institut 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1448669421 Hofmann, Wolf-Karsten 2013 01 DE-16-250 09 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_9 2013 01 DE-16-250 10 p (DE-627)1460939530 Fabarius, Alice 2013 01 DE-16-250 10 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_12 2013 01 DE-16-250 11 p (DE-627)1446321282 Reiter, Andreas 2013 01 DE-16-250 11 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_13
allfields_unstemmed	10.1002/ajh.24075 doi (DE-627)1570654603 (DE-576)500654603 (DE-599)BSZ500654603 (OCoLC)1340994060 DE-627 ger DE-627 rda eng Schwaab, Juliana 1982- verfasserin (DE-588)1051912687 (DE-627)787019399 (DE-576)407558764 aut KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance Juliana Schwaab, Roland Umbach, Georgia Metzgeroth, Nicole Naumann, Mohamad Jawhar, Karl Sotlar, Hans-Peter Horny, Timo Gaiser, Wolf-Karsten Hofmann, Susanne Schnittger, Nicholas C.P. Cross, Alice Fabarius, and Andreas Reiter 28 May 2015 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 08.03.2018 Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (FP) fusion gene also for KIT D816V and JAK2 V617F mutations. Overall, 86 (20%) patients tested positive: FP+ in 55 (12%), KIT D816V+ in 14 (3%), and JAK2 V617F+ in 17 (4%) patients, respectively. To gain better insight into clinical characteristics, we compared these cases with 31 additional and well-characterized KIT D816V+ eosinophilia-associated systemic mastocytosis (SM-eo) patients enrolled within the “German Registry on Disorders of Eosinophils and Mast cells.” Significant differences included younger age, male predominance, and higher eosinophil counts for FP+ cases while abdominal lymphadenopathy, ascites, and serum tryptase levels >100 μg/l were characteristic for those with KIT D816V. Leukocytes, hemoglobin, and splenomegaly did not differ significantly. A median of three additional mutations, most frequently TET2 and SRSF2, were identified in 12/13 KIT D816V+ SM-eo patients with available material indicating a more complex molecular pathogenesis. Median survival was not reached for FP+ cases but was only 26 and 41 months for KIT D816V+ SM and JAK2 V617F+ MPN-eo, respectively. Eosinophilia of ≥2 × 109/l was identified as discriminator for inferior survival in KIT D816V+ and/or JAK2 V617F+ patients (median survival 20 months vs. not reached, P = 0.002). Thus, there is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia. Metzgeroth, Georgia 1972- verfasserin (DE-588)1051897661 (DE-627)786986832 (DE-576)407534075 aut Naumann, Nicole 1988- verfasserin (DE-588)1138951838 (DE-627)896569624 (DE-576)49279314X aut Jawhar, Mohamad 1986- verfasserin (DE-588)1046172905 (DE-627)775847747 (DE-576)399437061 aut Gaiser, Timo 1975- verfasserin (DE-588)1030402280 (DE-627)735221685 (DE-576)378226533 aut Hofmann, Wolf-Karsten 1967- verfasserin (DE-588)114154635 (DE-627)691208751 (DE-576)351568336 aut Fabarius, Alice 1965- verfasserin (DE-588)1037001281 (DE-627)751728314 (DE-576)390896667 aut Reiter, Andreas 1964- verfasserin (DE-588)172629551 (DE-627)697563766 (DE-576)133488594 aut Enthalten in American journal of hematology New York, NY : Wiley-Liss, 1976 90(2015), 9, Seite 774-777 Online-Ressource (DE-627)302923349 (DE-600)1492749-4 (DE-576)094060002 1096-8652 nnns volume:90 year:2015 number:9 pages:774-777 extent:4 http://dx.doi.org/10.1002/ajh.24075 Verlag Resolving-System teilw. kostenfrei Volltext http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/ajh.24075/abstract Verlag teilw. kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 90 2015 9 774-777 4 2013 01 DE-16-250 3002130044 00 --%%-- --%%-- --%%-- --%%-- l01 08-03-18 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_13 2013 01 DE-16-250 03 s s_4 2013 01 DE-16-250 04 p (DE-627)1477558896 Schwaab, Juliana 2013 01 DE-16-250 04 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1477558845 Metzgeroth, Georgia 2013 01 DE-16-250 05 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_3 2013 01 DE-16-250 06 p (DE-627)1562793470 Naumann, Nicole 2013 01 DE-16-250 06 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1482083817 Jawhar, Mohamad 2013 01 DE-16-250 07 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_5 2013 01 DE-16-250 08 p (DE-627)1448227135 Gaiser, Timo 2013 01 DE-16-250 08 k (DE-627)141646882X Pathologisches Institut 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1448669421 Hofmann, Wolf-Karsten 2013 01 DE-16-250 09 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_9 2013 01 DE-16-250 10 p (DE-627)1460939530 Fabarius, Alice 2013 01 DE-16-250 10 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_12 2013 01 DE-16-250 11 p (DE-627)1446321282 Reiter, Andreas 2013 01 DE-16-250 11 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_13
allfieldsGer	10.1002/ajh.24075 doi (DE-627)1570654603 (DE-576)500654603 (DE-599)BSZ500654603 (OCoLC)1340994060 DE-627 ger DE-627 rda eng Schwaab, Juliana 1982- verfasserin (DE-588)1051912687 (DE-627)787019399 (DE-576)407558764 aut KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance Juliana Schwaab, Roland Umbach, Georgia Metzgeroth, Nicole Naumann, Mohamad Jawhar, Karl Sotlar, Hans-Peter Horny, Timo Gaiser, Wolf-Karsten Hofmann, Susanne Schnittger, Nicholas C.P. Cross, Alice Fabarius, and Andreas Reiter 28 May 2015 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 08.03.2018 Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (FP) fusion gene also for KIT D816V and JAK2 V617F mutations. Overall, 86 (20%) patients tested positive: FP+ in 55 (12%), KIT D816V+ in 14 (3%), and JAK2 V617F+ in 17 (4%) patients, respectively. To gain better insight into clinical characteristics, we compared these cases with 31 additional and well-characterized KIT D816V+ eosinophilia-associated systemic mastocytosis (SM-eo) patients enrolled within the “German Registry on Disorders of Eosinophils and Mast cells.” Significant differences included younger age, male predominance, and higher eosinophil counts for FP+ cases while abdominal lymphadenopathy, ascites, and serum tryptase levels >100 μg/l were characteristic for those with KIT D816V. Leukocytes, hemoglobin, and splenomegaly did not differ significantly. A median of three additional mutations, most frequently TET2 and SRSF2, were identified in 12/13 KIT D816V+ SM-eo patients with available material indicating a more complex molecular pathogenesis. Median survival was not reached for FP+ cases but was only 26 and 41 months for KIT D816V+ SM and JAK2 V617F+ MPN-eo, respectively. Eosinophilia of ≥2 × 109/l was identified as discriminator for inferior survival in KIT D816V+ and/or JAK2 V617F+ patients (median survival 20 months vs. not reached, P = 0.002). Thus, there is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia. Metzgeroth, Georgia 1972- verfasserin (DE-588)1051897661 (DE-627)786986832 (DE-576)407534075 aut Naumann, Nicole 1988- verfasserin (DE-588)1138951838 (DE-627)896569624 (DE-576)49279314X aut Jawhar, Mohamad 1986- verfasserin (DE-588)1046172905 (DE-627)775847747 (DE-576)399437061 aut Gaiser, Timo 1975- verfasserin (DE-588)1030402280 (DE-627)735221685 (DE-576)378226533 aut Hofmann, Wolf-Karsten 1967- verfasserin (DE-588)114154635 (DE-627)691208751 (DE-576)351568336 aut Fabarius, Alice 1965- verfasserin (DE-588)1037001281 (DE-627)751728314 (DE-576)390896667 aut Reiter, Andreas 1964- verfasserin (DE-588)172629551 (DE-627)697563766 (DE-576)133488594 aut Enthalten in American journal of hematology New York, NY : Wiley-Liss, 1976 90(2015), 9, Seite 774-777 Online-Ressource (DE-627)302923349 (DE-600)1492749-4 (DE-576)094060002 1096-8652 nnns volume:90 year:2015 number:9 pages:774-777 extent:4 http://dx.doi.org/10.1002/ajh.24075 Verlag Resolving-System teilw. kostenfrei Volltext http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/ajh.24075/abstract Verlag teilw. kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 90 2015 9 774-777 4 2013 01 DE-16-250 3002130044 00 --%%-- --%%-- --%%-- --%%-- l01 08-03-18 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_13 2013 01 DE-16-250 03 s s_4 2013 01 DE-16-250 04 p (DE-627)1477558896 Schwaab, Juliana 2013 01 DE-16-250 04 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1477558845 Metzgeroth, Georgia 2013 01 DE-16-250 05 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_3 2013 01 DE-16-250 06 p (DE-627)1562793470 Naumann, Nicole 2013 01 DE-16-250 06 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1482083817 Jawhar, Mohamad 2013 01 DE-16-250 07 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_5 2013 01 DE-16-250 08 p (DE-627)1448227135 Gaiser, Timo 2013 01 DE-16-250 08 k (DE-627)141646882X Pathologisches Institut 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1448669421 Hofmann, Wolf-Karsten 2013 01 DE-16-250 09 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_9 2013 01 DE-16-250 10 p (DE-627)1460939530 Fabarius, Alice 2013 01 DE-16-250 10 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_12 2013 01 DE-16-250 11 p (DE-627)1446321282 Reiter, Andreas 2013 01 DE-16-250 11 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_13
allfieldsSound	10.1002/ajh.24075 doi (DE-627)1570654603 (DE-576)500654603 (DE-599)BSZ500654603 (OCoLC)1340994060 DE-627 ger DE-627 rda eng Schwaab, Juliana 1982- verfasserin (DE-588)1051912687 (DE-627)787019399 (DE-576)407558764 aut KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance Juliana Schwaab, Roland Umbach, Georgia Metzgeroth, Nicole Naumann, Mohamad Jawhar, Karl Sotlar, Hans-Peter Horny, Timo Gaiser, Wolf-Karsten Hofmann, Susanne Schnittger, Nicholas C.P. Cross, Alice Fabarius, and Andreas Reiter 28 May 2015 4 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Gesehen am 08.03.2018 Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (FP) fusion gene also for KIT D816V and JAK2 V617F mutations. Overall, 86 (20%) patients tested positive: FP+ in 55 (12%), KIT D816V+ in 14 (3%), and JAK2 V617F+ in 17 (4%) patients, respectively. To gain better insight into clinical characteristics, we compared these cases with 31 additional and well-characterized KIT D816V+ eosinophilia-associated systemic mastocytosis (SM-eo) patients enrolled within the “German Registry on Disorders of Eosinophils and Mast cells.” Significant differences included younger age, male predominance, and higher eosinophil counts for FP+ cases while abdominal lymphadenopathy, ascites, and serum tryptase levels >100 μg/l were characteristic for those with KIT D816V. Leukocytes, hemoglobin, and splenomegaly did not differ significantly. A median of three additional mutations, most frequently TET2 and SRSF2, were identified in 12/13 KIT D816V+ SM-eo patients with available material indicating a more complex molecular pathogenesis. Median survival was not reached for FP+ cases but was only 26 and 41 months for KIT D816V+ SM and JAK2 V617F+ MPN-eo, respectively. Eosinophilia of ≥2 × 109/l was identified as discriminator for inferior survival in KIT D816V+ and/or JAK2 V617F+ patients (median survival 20 months vs. not reached, P = 0.002). Thus, there is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia. Metzgeroth, Georgia 1972- verfasserin (DE-588)1051897661 (DE-627)786986832 (DE-576)407534075 aut Naumann, Nicole 1988- verfasserin (DE-588)1138951838 (DE-627)896569624 (DE-576)49279314X aut Jawhar, Mohamad 1986- verfasserin (DE-588)1046172905 (DE-627)775847747 (DE-576)399437061 aut Gaiser, Timo 1975- verfasserin (DE-588)1030402280 (DE-627)735221685 (DE-576)378226533 aut Hofmann, Wolf-Karsten 1967- verfasserin (DE-588)114154635 (DE-627)691208751 (DE-576)351568336 aut Fabarius, Alice 1965- verfasserin (DE-588)1037001281 (DE-627)751728314 (DE-576)390896667 aut Reiter, Andreas 1964- verfasserin (DE-588)172629551 (DE-627)697563766 (DE-576)133488594 aut Enthalten in American journal of hematology New York, NY : Wiley-Liss, 1976 90(2015), 9, Seite 774-777 Online-Ressource (DE-627)302923349 (DE-600)1492749-4 (DE-576)094060002 1096-8652 nnns volume:90 year:2015 number:9 pages:774-777 extent:4 http://dx.doi.org/10.1002/ajh.24075 Verlag Resolving-System teilw. kostenfrei Volltext http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/ajh.24075/abstract Verlag teilw. kostenfrei Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP GBV_ILN_11 GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_39 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_120 GBV_ILN_138 GBV_ILN_150 GBV_ILN_151 GBV_ILN_161 GBV_ILN_170 GBV_ILN_171 GBV_ILN_187 GBV_ILN_206 GBV_ILN_213 GBV_ILN_224 GBV_ILN_230 GBV_ILN_266 GBV_ILN_285 GBV_ILN_293 GBV_ILN_370 GBV_ILN_602 GBV_ILN_636 GBV_ILN_647 GBV_ILN_702 GBV_ILN_2001 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2006 GBV_ILN_2007 GBV_ILN_2008 GBV_ILN_2009 GBV_ILN_2010 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2018 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2031 GBV_ILN_2034 GBV_ILN_2037 GBV_ILN_2038 GBV_ILN_2039 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2055 GBV_ILN_2056 GBV_ILN_2057 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2068 GBV_ILN_2088 GBV_ILN_2093 GBV_ILN_2106 GBV_ILN_2108 GBV_ILN_2110 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2119 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2144 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2188 GBV_ILN_2190 GBV_ILN_2232 GBV_ILN_2336 GBV_ILN_2470 GBV_ILN_2472 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_2548 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4046 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4246 GBV_ILN_4249 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4306 GBV_ILN_4307 GBV_ILN_4313 GBV_ILN_4322 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4325 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4336 GBV_ILN_4338 GBV_ILN_4367 GBV_ILN_4393 GBV_ILN_4700 AR 90 2015 9 774-777 4 2013 01 DE-16-250 3002130044 00 --%%-- --%%-- --%%-- --%%-- l01 08-03-18 2013 01 DE-16-250 00 s hd2015 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_13 2013 01 DE-16-250 03 s s_4 2013 01 DE-16-250 04 p (DE-627)1477558896 Schwaab, Juliana 2013 01 DE-16-250 04 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1 2013 01 DE-16-250 05 p (DE-627)1477558845 Metzgeroth, Georgia 2013 01 DE-16-250 05 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 05 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 05 s pos_3 2013 01 DE-16-250 06 p (DE-627)1562793470 Naumann, Nicole 2013 01 DE-16-250 06 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 06 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 06 s pos_4 2013 01 DE-16-250 07 p (DE-627)1482083817 Jawhar, Mohamad 2013 01 DE-16-250 07 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 07 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 07 s pos_5 2013 01 DE-16-250 08 p (DE-627)1448227135 Gaiser, Timo 2013 01 DE-16-250 08 k (DE-627)141646882X Pathologisches Institut 2013 01 DE-16-250 08 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 08 s pos_8 2013 01 DE-16-250 09 p (DE-627)1448669421 Hofmann, Wolf-Karsten 2013 01 DE-16-250 09 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 09 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 09 s pos_9 2013 01 DE-16-250 10 p (DE-627)1460939530 Fabarius, Alice 2013 01 DE-16-250 10 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 10 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 10 s pos_12 2013 01 DE-16-250 11 p (DE-627)1446321282 Reiter, Andreas 2013 01 DE-16-250 11 k (DE-627)1416468528 III. Medizinische Klinik 2013 01 DE-16-250 11 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 11 s pos_13
language	English
source	Enthalten in American journal of hematology 90(2015), 9, Seite 774-777 volume:90 year:2015 number:9 pages:774-777 extent:4
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container_title	American journal of hematology
authorswithroles_txt_mv	Schwaab, Juliana @@aut@@ Metzgeroth, Georgia @@aut@@ Naumann, Nicole @@aut@@ Jawhar, Mohamad @@aut@@ Gaiser, Timo @@aut@@ Hofmann, Wolf-Karsten @@aut@@ Fabarius, Alice @@aut@@ Reiter, Andreas @@aut@@
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fullrecord	<?xml version="1.0" encoding="UTF-8"?><collection xmlns="http://www.loc.gov/MARC21/slim"><record><leader>01000caa a2200265 4500</leader><controlfield tag="001">1570654603</controlfield><controlfield tag="003">DE-627</controlfield><controlfield tag="005">20220814090840.0</controlfield><controlfield tag="007">cr uuu---uuuuu</controlfield><controlfield tag="008">180308s2015 xx \|\|\|\|\|o 00\| \|\|eng c</controlfield><datafield tag="024" ind1="7" ind2=" "><subfield code="a">10.1002/ajh.24075</subfield><subfield code="2">doi</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-627)1570654603</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-576)500654603</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(DE-599)BSZ500654603</subfield></datafield><datafield tag="035" ind1=" " ind2=" "><subfield code="a">(OCoLC)1340994060</subfield></datafield><datafield tag="040" ind1=" " ind2=" "><subfield code="a">DE-627</subfield><subfield code="b">ger</subfield><subfield code="c">DE-627</subfield><subfield code="e">rda</subfield></datafield><datafield tag="041" ind1=" " ind2=" "><subfield code="a">eng</subfield></datafield><datafield tag="100" ind1="1" ind2=" "><subfield code="a">Schwaab, Juliana</subfield><subfield code="d">1982-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1051912687</subfield><subfield code="0">(DE-627)787019399</subfield><subfield code="0">(DE-576)407558764</subfield><subfield code="4">aut</subfield></datafield><datafield tag="245" ind1="1" ind2="0"><subfield code="a">KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance</subfield><subfield code="c">Juliana Schwaab, Roland Umbach, Georgia Metzgeroth, Nicole Naumann, Mohamad Jawhar, Karl Sotlar, Hans-Peter Horny, Timo Gaiser, Wolf-Karsten Hofmann, Susanne Schnittger, Nicholas C.P. Cross, Alice Fabarius, and Andreas Reiter</subfield></datafield><datafield tag="264" ind1=" " ind2="1"><subfield code="c">28 May 2015</subfield></datafield><datafield tag="300" ind1=" " ind2=" "><subfield code="a">4</subfield></datafield><datafield tag="336" ind1=" " ind2=" "><subfield code="a">Text</subfield><subfield code="b">txt</subfield><subfield code="2">rdacontent</subfield></datafield><datafield tag="337" ind1=" " ind2=" "><subfield code="a">Computermedien</subfield><subfield code="b">c</subfield><subfield code="2">rdamedia</subfield></datafield><datafield tag="338" ind1=" " ind2=" "><subfield code="a">Online-Ressource</subfield><subfield code="b">cr</subfield><subfield code="2">rdacarrier</subfield></datafield><datafield tag="500" ind1=" " ind2=" "><subfield code="a">Gesehen am 08.03.2018</subfield></datafield><datafield tag="520" ind1=" " ind2=" "><subfield code="a">Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (FP) fusion gene also for KIT D816V and JAK2 V617F mutations. Overall, 86 (20%) patients tested positive: FP+ in 55 (12%), KIT D816V+ in 14 (3%), and JAK2 V617F+ in 17 (4%) patients, respectively. To gain better insight into clinical characteristics, we compared these cases with 31 additional and well-characterized KIT D816V+ eosinophilia-associated systemic mastocytosis (SM-eo) patients enrolled within the “German Registry on Disorders of Eosinophils and Mast cells.” Significant differences included younger age, male predominance, and higher eosinophil counts for FP+ cases while abdominal lymphadenopathy, ascites, and serum tryptase levels >100 μg/l were characteristic for those with KIT D816V. Leukocytes, hemoglobin, and splenomegaly did not differ significantly. A median of three additional mutations, most frequently TET2 and SRSF2, were identified in 12/13 KIT D816V+ SM-eo patients with available material indicating a more complex molecular pathogenesis. Median survival was not reached for FP+ cases but was only 26 and 41 months for KIT D816V+ SM and JAK2 V617F+ MPN-eo, respectively. Eosinophilia of ≥2 × 109/l was identified as discriminator for inferior survival in KIT D816V+ and/or JAK2 V617F+ patients (median survival 20 months vs. not reached, P = 0.002). Thus, there is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia.</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Metzgeroth, Georgia</subfield><subfield code="d">1972-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1051897661</subfield><subfield code="0">(DE-627)786986832</subfield><subfield code="0">(DE-576)407534075</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Naumann, Nicole</subfield><subfield code="d">1988-</subfield><subfield code="e">verfasserin</subfield><subfield code="0">(DE-588)1138951838</subfield><subfield code="0">(DE-627)896569624</subfield><subfield code="0">(DE-576)49279314X</subfield><subfield code="4">aut</subfield></datafield><datafield tag="700" ind1="1" ind2=" "><subfield code="a">Jawhar, Mohamad</subfield><subfield code="d">1986-</subfield><subfield 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title	KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance
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title_full	KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance Juliana Schwaab, Roland Umbach, Georgia Metzgeroth, Nicole Naumann, Mohamad Jawhar, Karl Sotlar, Hans-Peter Horny, Timo Gaiser, Wolf-Karsten Hofmann, Susanne Schnittger, Nicholas C.P. Cross, Alice Fabarius, and Andreas Reiter
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author2-role	verfasserin
title_sort	kit d816v and jak2 v617f mutations are seen recurrently in hypereosinophilia of unknown significance
title_auth	KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance
abstract	Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (FP) fusion gene also for KIT D816V and JAK2 V617F mutations. Overall, 86 (20%) patients tested positive: FP+ in 55 (12%), KIT D816V+ in 14 (3%), and JAK2 V617F+ in 17 (4%) patients, respectively. To gain better insight into clinical characteristics, we compared these cases with 31 additional and well-characterized KIT D816V+ eosinophilia-associated systemic mastocytosis (SM-eo) patients enrolled within the “German Registry on Disorders of Eosinophils and Mast cells.” Significant differences included younger age, male predominance, and higher eosinophil counts for FP+ cases while abdominal lymphadenopathy, ascites, and serum tryptase levels >100 μg/l were characteristic for those with KIT D816V. Leukocytes, hemoglobin, and splenomegaly did not differ significantly. A median of three additional mutations, most frequently TET2 and SRSF2, were identified in 12/13 KIT D816V+ SM-eo patients with available material indicating a more complex molecular pathogenesis. Median survival was not reached for FP+ cases but was only 26 and 41 months for KIT D816V+ SM and JAK2 V617F+ MPN-eo, respectively. Eosinophilia of ≥2 × 109/l was identified as discriminator for inferior survival in KIT D816V+ and/or JAK2 V617F+ patients (median survival 20 months vs. not reached, P = 0.002). Thus, there is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia. Gesehen am 08.03.2018
abstractGer	Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (FP) fusion gene also for KIT D816V and JAK2 V617F mutations. Overall, 86 (20%) patients tested positive: FP+ in 55 (12%), KIT D816V+ in 14 (3%), and JAK2 V617F+ in 17 (4%) patients, respectively. To gain better insight into clinical characteristics, we compared these cases with 31 additional and well-characterized KIT D816V+ eosinophilia-associated systemic mastocytosis (SM-eo) patients enrolled within the “German Registry on Disorders of Eosinophils and Mast cells.” Significant differences included younger age, male predominance, and higher eosinophil counts for FP+ cases while abdominal lymphadenopathy, ascites, and serum tryptase levels >100 μg/l were characteristic for those with KIT D816V. Leukocytes, hemoglobin, and splenomegaly did not differ significantly. A median of three additional mutations, most frequently TET2 and SRSF2, were identified in 12/13 KIT D816V+ SM-eo patients with available material indicating a more complex molecular pathogenesis. Median survival was not reached for FP+ cases but was only 26 and 41 months for KIT D816V+ SM and JAK2 V617F+ MPN-eo, respectively. Eosinophilia of ≥2 × 109/l was identified as discriminator for inferior survival in KIT D816V+ and/or JAK2 V617F+ patients (median survival 20 months vs. not reached, P = 0.002). Thus, there is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia. Gesehen am 08.03.2018
abstract_unstemmed	Myeloproliferative neoplasms with eosinophilia are commonly characterized by a normal karyotype and remain poorly defined at the molecular level. We therefore investigated 426 samples from patients with hypereosinophilia of unknown significance initially referred for screening of the FIP1L1-PDGFRA (FP) fusion gene also for KIT D816V and JAK2 V617F mutations. Overall, 86 (20%) patients tested positive: FP+ in 55 (12%), KIT D816V+ in 14 (3%), and JAK2 V617F+ in 17 (4%) patients, respectively. To gain better insight into clinical characteristics, we compared these cases with 31 additional and well-characterized KIT D816V+ eosinophilia-associated systemic mastocytosis (SM-eo) patients enrolled within the “German Registry on Disorders of Eosinophils and Mast cells.” Significant differences included younger age, male predominance, and higher eosinophil counts for FP+ cases while abdominal lymphadenopathy, ascites, and serum tryptase levels >100 μg/l were characteristic for those with KIT D816V. Leukocytes, hemoglobin, and splenomegaly did not differ significantly. A median of three additional mutations, most frequently TET2 and SRSF2, were identified in 12/13 KIT D816V+ SM-eo patients with available material indicating a more complex molecular pathogenesis. Median survival was not reached for FP+ cases but was only 26 and 41 months for KIT D816V+ SM and JAK2 V617F+ MPN-eo, respectively. Eosinophilia of ≥2 × 109/l was identified as discriminator for inferior survival in KIT D816V+ and/or JAK2 V617F+ patients (median survival 20 months vs. not reached, P = 0.002). Thus, there is a clear prognostic and therapeutic rationale for detection of KIT D816V and JAK2 V617F in the diagnostic work up of eosinophilia. Gesehen am 08.03.2018
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container_issue	9
title_short	KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance
url	http://dx.doi.org/10.1002/ajh.24075 http://onlinelibrary.wiley.com.ezproxy.medma.uni-heidelberg.de/doi/10.1002/ajh.24075/abstract
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author2	Metzgeroth, Georgia 1972- Naumann, Nicole 1988- Jawhar, Mohamad 1986- Gaiser, Timo 1975- Hofmann, Wolf-Karsten 1967- Fabarius, Alice 1965- Reiter, Andreas 1964-
author2Str	Metzgeroth, Georgia 1972- Naumann, Nicole 1988- Jawhar, Mohamad 1986- Gaiser, Timo 1975- Hofmann, Wolf-Karsten 1967- Fabarius, Alice 1965- Reiter, Andreas 1964-
ppnlink	302923349
GND_str_mv	Schwaab, Juliana-Justina Schwaab, J. Schwaab, Juliane Schwaab, Juliana Metzgeroth, Georgia Secunda Metzgeroth, G. Metzgeroth, Georgia Naumann, Nicole Maria Naumann, N. Naumann, Nicole Jawhar, M. Jawhar, Mohamad Gaiser, T. Gaiser, Timo Hofmann, Wolf-K. Hofmann, W. K. Hofmann, W.-K. Hofmann, Wolf-Karsten Fabarius, Alice Charlotte Fabarius, A. Fabarius, Alice Reiter, Andreas J. Reiter, A. Reiter, Andreas Johannes Reiter, Andreas
GND_txt_mv	Schwaab, Juliana-Justina Schwaab, J. Schwaab, Juliane Schwaab, Juliana Metzgeroth, Georgia Secunda Metzgeroth, G. Metzgeroth, Georgia Naumann, Nicole Maria Naumann, N. Naumann, Nicole Jawhar, M. Jawhar, Mohamad Gaiser, T. Gaiser, Timo Hofmann, Wolf-K. Hofmann, W. K. Hofmann, W.-K. Hofmann, Wolf-Karsten Fabarius, Alice Charlotte Fabarius, A. Fabarius, Alice Reiter, Andreas J. Reiter, A. Reiter, Andreas Johannes Reiter, Andreas
GND_txtF_mv	Schwaab, Juliana-Justina Schwaab, J. Schwaab, Juliane Schwaab, Juliana Metzgeroth, Georgia Secunda Metzgeroth, G. Metzgeroth, Georgia Naumann, Nicole Maria Naumann, N. Naumann, Nicole Jawhar, M. Jawhar, Mohamad Gaiser, T. Gaiser, Timo Hofmann, Wolf-K. Hofmann, W. K. Hofmann, W.-K. Hofmann, Wolf-Karsten Fabarius, Alice Charlotte Fabarius, A. Fabarius, Alice Reiter, Andreas J. Reiter, A. Reiter, Andreas Johannes Reiter, Andreas
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doi_str	10.1002/ajh.24075
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up_date	2024-07-04T17:39:26.187Z
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KIT D816V and JAK2 V617F mutations are seen recurrently in hypereosinophilia of unknown significance

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