PSA-NCAM : synaptic functions mediated by its interactions with proteoglycans and glutamate receptors

Dynamic regulation of glycosylation of the neural cell adhesion molecule (NCAM) by an unusual large negatively charged polysialic acid (PSA) is the major prerequisite for correct formation of brain circuitries during development and for normal synaptic plasticity, learning and memory in the adult. T...
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Gespeichert in:

Autor*in:	Senkov, Oleg [verfasserIn] Tikhobrazova, Olga [verfasserIn] Dityatev, Alexander [verfasserIn]

Format:	E-Artikel
Sprache:	Englisch

Erschienen:	25 January 2012

Schlagwörter:	GluN2B Learning NCAM Polysialic acid PSA PSA-NCAM Synaptic plasticity

Anmerkung:	Available online 25 January 2012 Gesehen am 06.07.2018
Umfang:	5

Übergeordnetes Werk:	Enthalten in: International journal of biochemistry & cell biology - Amsterdam : Elsevier, 1995, 44(2012), 4, Seite 591-595
Übergeordnetes Werk:	volume:44 ; year:2012 ; number:4 ; pages:591-595 ; extent:5

Links:	Volltext Volltext

DOI / URN:	10.1016/j.biocel.2012.01.008

Katalog-ID:	1577385683

Internformat


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912			\|a GBV_ILN_32
912			\|a GBV_ILN_40
912			\|a GBV_ILN_60
912			\|a GBV_ILN_62
912			\|a GBV_ILN_63
912			\|a GBV_ILN_65
912			\|a GBV_ILN_69
912			\|a GBV_ILN_70
912			\|a GBV_ILN_73
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912			\|a GBV_ILN_602
912			\|a GBV_ILN_702
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912			\|a GBV_ILN_2004
912			\|a GBV_ILN_2005
912			\|a GBV_ILN_2011
912			\|a GBV_ILN_2014
912			\|a GBV_ILN_2015
912			\|a GBV_ILN_2020
912			\|a GBV_ILN_2021
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912			\|a GBV_ILN_2026
912			\|a GBV_ILN_2027
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912			\|a GBV_ILN_4037
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912			\|a GBV_ILN_4251
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912			\|a GBV_ILN_4313
912			\|a GBV_ILN_4323
912			\|a GBV_ILN_4324
912			\|a GBV_ILN_4326
912			\|a GBV_ILN_4333
912			\|a GBV_ILN_4334
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allfields	10.1016/j.biocel.2012.01.008 doi (DE-627)1577385683 (DE-576)507385683 (DE-599)BSZ507385683 (OCoLC)1341013496 DE-627 ger DE-627 rda eng Senkov, Oleg verfasserin (DE-588)132778882 (DE-627)526932082 (DE-576)299407454 aut PSA-NCAM synaptic functions mediated by its interactions with proteoglycans and glutamate receptors Oleg Senkov, Olga Tikhobrazova, Alexander Dityatev 25 January 2012 5 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Available online 25 January 2012 Gesehen am 06.07.2018 Dynamic regulation of glycosylation of the neural cell adhesion molecule (NCAM) by an unusual large negatively charged polysialic acid (PSA) is the major prerequisite for correct formation of brain circuitries during development and for normal synaptic plasticity, learning and memory in the adult. Traditionally, PSA is viewed as a de-adhesive highly hydrated molecule, which interferes with cell adhesion and promotes cellular/synaptic dynamics by steric hindrance. Analysis of synaptic functions of PSA-NCAM highlighted additional features of this molecule. First, PSA promotes interaction of NCAM with heparan sulfate proteoglycans and thus stimulates synaptogenesis. Second, PSA-NCAM modulates glutamate receptors: it restrains activity of extrasynaptic GluN2B-containing NMDA receptors and facilitates activity of a subset of AMPA receptors. Perturbation in polysialylation and/or NCAM expression in mouse models recapitulates many symptoms of human brain disorders such as schizophrenia, depression, anxiety and Alzheimer's disease. GluN2B Learning NCAM Polysialic acid PSA PSA-NCAM Synaptic plasticity Tikhobrazova, Olga verfasserin (DE-588)1162363231 (DE-627)1026032369 (DE-576)507385594 aut Dityatev, Alexander verfasserin (DE-588)1027216242 (DE-627)728611465 (DE-576)37262393X aut Enthalten in International journal of biochemistry & cell biology Amsterdam : Elsevier, 1995 44(2012), 4, Seite 591-595 Online-Ressource (DE-627)320412261 (DE-600)2001470-3 (DE-576)094531323 1878-5875 nnns volume:44 year:2012 number:4 pages:591-595 extent:5 http://dx.doi.org/10.1016/j.biocel.2012.01.008 Verlag Resolving-System Volltext http://www.sciencedirect.com/science/article/pii/S135727251200012X Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 44 2012 4 591-595 5 2013 01 DE-16-250 3016623323 00 --%%-- --%%-- --%%-- --%%-- l01 06-07-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_3 2013 01 DE-16-250 03 s s_5 2013 01 DE-16-250 04 p (DE-627)1500210943 Senkov, Oleg 2013 01 DE-16-250 04 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1
spelling	10.1016/j.biocel.2012.01.008 doi (DE-627)1577385683 (DE-576)507385683 (DE-599)BSZ507385683 (OCoLC)1341013496 DE-627 ger DE-627 rda eng Senkov, Oleg verfasserin (DE-588)132778882 (DE-627)526932082 (DE-576)299407454 aut PSA-NCAM synaptic functions mediated by its interactions with proteoglycans and glutamate receptors Oleg Senkov, Olga Tikhobrazova, Alexander Dityatev 25 January 2012 5 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Available online 25 January 2012 Gesehen am 06.07.2018 Dynamic regulation of glycosylation of the neural cell adhesion molecule (NCAM) by an unusual large negatively charged polysialic acid (PSA) is the major prerequisite for correct formation of brain circuitries during development and for normal synaptic plasticity, learning and memory in the adult. Traditionally, PSA is viewed as a de-adhesive highly hydrated molecule, which interferes with cell adhesion and promotes cellular/synaptic dynamics by steric hindrance. Analysis of synaptic functions of PSA-NCAM highlighted additional features of this molecule. First, PSA promotes interaction of NCAM with heparan sulfate proteoglycans and thus stimulates synaptogenesis. Second, PSA-NCAM modulates glutamate receptors: it restrains activity of extrasynaptic GluN2B-containing NMDA receptors and facilitates activity of a subset of AMPA receptors. Perturbation in polysialylation and/or NCAM expression in mouse models recapitulates many symptoms of human brain disorders such as schizophrenia, depression, anxiety and Alzheimer's disease. GluN2B Learning NCAM Polysialic acid PSA PSA-NCAM Synaptic plasticity Tikhobrazova, Olga verfasserin (DE-588)1162363231 (DE-627)1026032369 (DE-576)507385594 aut Dityatev, Alexander verfasserin (DE-588)1027216242 (DE-627)728611465 (DE-576)37262393X aut Enthalten in International journal of biochemistry & cell biology Amsterdam : Elsevier, 1995 44(2012), 4, Seite 591-595 Online-Ressource (DE-627)320412261 (DE-600)2001470-3 (DE-576)094531323 1878-5875 nnns volume:44 year:2012 number:4 pages:591-595 extent:5 http://dx.doi.org/10.1016/j.biocel.2012.01.008 Verlag Resolving-System Volltext http://www.sciencedirect.com/science/article/pii/S135727251200012X Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 44 2012 4 591-595 5 2013 01 DE-16-250 3016623323 00 --%%-- --%%-- --%%-- --%%-- l01 06-07-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_3 2013 01 DE-16-250 03 s s_5 2013 01 DE-16-250 04 p (DE-627)1500210943 Senkov, Oleg 2013 01 DE-16-250 04 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1
allfields_unstemmed	10.1016/j.biocel.2012.01.008 doi (DE-627)1577385683 (DE-576)507385683 (DE-599)BSZ507385683 (OCoLC)1341013496 DE-627 ger DE-627 rda eng Senkov, Oleg verfasserin (DE-588)132778882 (DE-627)526932082 (DE-576)299407454 aut PSA-NCAM synaptic functions mediated by its interactions with proteoglycans and glutamate receptors Oleg Senkov, Olga Tikhobrazova, Alexander Dityatev 25 January 2012 5 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Available online 25 January 2012 Gesehen am 06.07.2018 Dynamic regulation of glycosylation of the neural cell adhesion molecule (NCAM) by an unusual large negatively charged polysialic acid (PSA) is the major prerequisite for correct formation of brain circuitries during development and for normal synaptic plasticity, learning and memory in the adult. Traditionally, PSA is viewed as a de-adhesive highly hydrated molecule, which interferes with cell adhesion and promotes cellular/synaptic dynamics by steric hindrance. Analysis of synaptic functions of PSA-NCAM highlighted additional features of this molecule. First, PSA promotes interaction of NCAM with heparan sulfate proteoglycans and thus stimulates synaptogenesis. Second, PSA-NCAM modulates glutamate receptors: it restrains activity of extrasynaptic GluN2B-containing NMDA receptors and facilitates activity of a subset of AMPA receptors. Perturbation in polysialylation and/or NCAM expression in mouse models recapitulates many symptoms of human brain disorders such as schizophrenia, depression, anxiety and Alzheimer's disease. GluN2B Learning NCAM Polysialic acid PSA PSA-NCAM Synaptic plasticity Tikhobrazova, Olga verfasserin (DE-588)1162363231 (DE-627)1026032369 (DE-576)507385594 aut Dityatev, Alexander verfasserin (DE-588)1027216242 (DE-627)728611465 (DE-576)37262393X aut Enthalten in International journal of biochemistry & cell biology Amsterdam : Elsevier, 1995 44(2012), 4, Seite 591-595 Online-Ressource (DE-627)320412261 (DE-600)2001470-3 (DE-576)094531323 1878-5875 nnns volume:44 year:2012 number:4 pages:591-595 extent:5 http://dx.doi.org/10.1016/j.biocel.2012.01.008 Verlag Resolving-System Volltext http://www.sciencedirect.com/science/article/pii/S135727251200012X Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 44 2012 4 591-595 5 2013 01 DE-16-250 3016623323 00 --%%-- --%%-- --%%-- --%%-- l01 06-07-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_3 2013 01 DE-16-250 03 s s_5 2013 01 DE-16-250 04 p (DE-627)1500210943 Senkov, Oleg 2013 01 DE-16-250 04 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1
allfieldsGer	10.1016/j.biocel.2012.01.008 doi (DE-627)1577385683 (DE-576)507385683 (DE-599)BSZ507385683 (OCoLC)1341013496 DE-627 ger DE-627 rda eng Senkov, Oleg verfasserin (DE-588)132778882 (DE-627)526932082 (DE-576)299407454 aut PSA-NCAM synaptic functions mediated by its interactions with proteoglycans and glutamate receptors Oleg Senkov, Olga Tikhobrazova, Alexander Dityatev 25 January 2012 5 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Available online 25 January 2012 Gesehen am 06.07.2018 Dynamic regulation of glycosylation of the neural cell adhesion molecule (NCAM) by an unusual large negatively charged polysialic acid (PSA) is the major prerequisite for correct formation of brain circuitries during development and for normal synaptic plasticity, learning and memory in the adult. Traditionally, PSA is viewed as a de-adhesive highly hydrated molecule, which interferes with cell adhesion and promotes cellular/synaptic dynamics by steric hindrance. Analysis of synaptic functions of PSA-NCAM highlighted additional features of this molecule. First, PSA promotes interaction of NCAM with heparan sulfate proteoglycans and thus stimulates synaptogenesis. Second, PSA-NCAM modulates glutamate receptors: it restrains activity of extrasynaptic GluN2B-containing NMDA receptors and facilitates activity of a subset of AMPA receptors. Perturbation in polysialylation and/or NCAM expression in mouse models recapitulates many symptoms of human brain disorders such as schizophrenia, depression, anxiety and Alzheimer's disease. GluN2B Learning NCAM Polysialic acid PSA PSA-NCAM Synaptic plasticity Tikhobrazova, Olga verfasserin (DE-588)1162363231 (DE-627)1026032369 (DE-576)507385594 aut Dityatev, Alexander verfasserin (DE-588)1027216242 (DE-627)728611465 (DE-576)37262393X aut Enthalten in International journal of biochemistry & cell biology Amsterdam : Elsevier, 1995 44(2012), 4, Seite 591-595 Online-Ressource (DE-627)320412261 (DE-600)2001470-3 (DE-576)094531323 1878-5875 nnns volume:44 year:2012 number:4 pages:591-595 extent:5 http://dx.doi.org/10.1016/j.biocel.2012.01.008 Verlag Resolving-System Volltext http://www.sciencedirect.com/science/article/pii/S135727251200012X Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 44 2012 4 591-595 5 2013 01 DE-16-250 3016623323 00 --%%-- --%%-- --%%-- --%%-- l01 06-07-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_3 2013 01 DE-16-250 03 s s_5 2013 01 DE-16-250 04 p (DE-627)1500210943 Senkov, Oleg 2013 01 DE-16-250 04 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1
allfieldsSound	10.1016/j.biocel.2012.01.008 doi (DE-627)1577385683 (DE-576)507385683 (DE-599)BSZ507385683 (OCoLC)1341013496 DE-627 ger DE-627 rda eng Senkov, Oleg verfasserin (DE-588)132778882 (DE-627)526932082 (DE-576)299407454 aut PSA-NCAM synaptic functions mediated by its interactions with proteoglycans and glutamate receptors Oleg Senkov, Olga Tikhobrazova, Alexander Dityatev 25 January 2012 5 Text txt rdacontent Computermedien c rdamedia Online-Ressource cr rdacarrier Available online 25 January 2012 Gesehen am 06.07.2018 Dynamic regulation of glycosylation of the neural cell adhesion molecule (NCAM) by an unusual large negatively charged polysialic acid (PSA) is the major prerequisite for correct formation of brain circuitries during development and for normal synaptic plasticity, learning and memory in the adult. Traditionally, PSA is viewed as a de-adhesive highly hydrated molecule, which interferes with cell adhesion and promotes cellular/synaptic dynamics by steric hindrance. Analysis of synaptic functions of PSA-NCAM highlighted additional features of this molecule. First, PSA promotes interaction of NCAM with heparan sulfate proteoglycans and thus stimulates synaptogenesis. Second, PSA-NCAM modulates glutamate receptors: it restrains activity of extrasynaptic GluN2B-containing NMDA receptors and facilitates activity of a subset of AMPA receptors. Perturbation in polysialylation and/or NCAM expression in mouse models recapitulates many symptoms of human brain disorders such as schizophrenia, depression, anxiety and Alzheimer's disease. GluN2B Learning NCAM Polysialic acid PSA PSA-NCAM Synaptic plasticity Tikhobrazova, Olga verfasserin (DE-588)1162363231 (DE-627)1026032369 (DE-576)507385594 aut Dityatev, Alexander verfasserin (DE-588)1027216242 (DE-627)728611465 (DE-576)37262393X aut Enthalten in International journal of biochemistry & cell biology Amsterdam : Elsevier, 1995 44(2012), 4, Seite 591-595 Online-Ressource (DE-627)320412261 (DE-600)2001470-3 (DE-576)094531323 1878-5875 nnns volume:44 year:2012 number:4 pages:591-595 extent:5 http://dx.doi.org/10.1016/j.biocel.2012.01.008 Verlag Resolving-System Volltext http://www.sciencedirect.com/science/article/pii/S135727251200012X Verlag Volltext GBV_USEFLAG_U GBV_ILN_2013 ISIL_DE-16-250 SYSFLAG_1 GBV_KXP SSG-OLC-PHA GBV_ILN_20 GBV_ILN_22 GBV_ILN_23 GBV_ILN_24 GBV_ILN_31 GBV_ILN_32 GBV_ILN_40 GBV_ILN_60 GBV_ILN_62 GBV_ILN_63 GBV_ILN_65 GBV_ILN_69 GBV_ILN_70 GBV_ILN_73 GBV_ILN_74 GBV_ILN_90 GBV_ILN_95 GBV_ILN_100 GBV_ILN_101 GBV_ILN_105 GBV_ILN_110 GBV_ILN_151 GBV_ILN_224 GBV_ILN_370 GBV_ILN_602 GBV_ILN_702 GBV_ILN_2003 GBV_ILN_2004 GBV_ILN_2005 GBV_ILN_2011 GBV_ILN_2014 GBV_ILN_2015 GBV_ILN_2020 GBV_ILN_2021 GBV_ILN_2025 GBV_ILN_2026 GBV_ILN_2027 GBV_ILN_2034 GBV_ILN_2038 GBV_ILN_2044 GBV_ILN_2048 GBV_ILN_2049 GBV_ILN_2050 GBV_ILN_2056 GBV_ILN_2059 GBV_ILN_2061 GBV_ILN_2064 GBV_ILN_2065 GBV_ILN_2068 GBV_ILN_2111 GBV_ILN_2112 GBV_ILN_2113 GBV_ILN_2118 GBV_ILN_2122 GBV_ILN_2129 GBV_ILN_2143 GBV_ILN_2147 GBV_ILN_2148 GBV_ILN_2152 GBV_ILN_2153 GBV_ILN_2190 GBV_ILN_2336 GBV_ILN_2507 GBV_ILN_2522 GBV_ILN_4012 GBV_ILN_4035 GBV_ILN_4037 GBV_ILN_4112 GBV_ILN_4125 GBV_ILN_4126 GBV_ILN_4242 GBV_ILN_4251 GBV_ILN_4305 GBV_ILN_4313 GBV_ILN_4323 GBV_ILN_4324 GBV_ILN_4326 GBV_ILN_4333 GBV_ILN_4334 GBV_ILN_4335 GBV_ILN_4338 GBV_ILN_4393 AR 44 2012 4 591-595 5 2013 01 DE-16-250 3016623323 00 --%%-- --%%-- --%%-- --%%-- l01 06-07-18 2013 01 DE-16-250 00 s hd2012 2013 01 DE-16-250 01 s (DE-627)1410508463 wissenschaftlicher Artikel (Zeitschrift) 2013 01 DE-16-250 02 s per_3 2013 01 DE-16-250 03 s s_5 2013 01 DE-16-250 04 p (DE-627)1500210943 Senkov, Oleg 2013 01 DE-16-250 04 k (DE-627)1416741267 Neurologische Universitätsklinik 2013 01 DE-16-250 04 s (DE-627)1410501914 Verfasser 2013 01 DE-16-250 04 s pos_1
language	English
source	Enthalten in International journal of biochemistry & cell biology 44(2012), 4, Seite 591-595 volume:44 year:2012 number:4 pages:591-595 extent:5
sourceStr	Enthalten in International journal of biochemistry & cell biology 44(2012), 4, Seite 591-595 volume:44 year:2012 number:4 pages:591-595 extent:5
format_phy_str_mv	Article
building	2013:0
institution	findex.gbv.de
selectbib_iln_str_mv	2013@01
topic_facet	GluN2B Learning NCAM Polysialic acid PSA PSA-NCAM Synaptic plasticity
sw_local_iln_str_mv	2013:hd2012 DE-16-250:hd2012 2013:wissenschaftlicher Artikel (Zeitschrift) DE-16-250:wissenschaftlicher Artikel (Zeitschrift) 2013:per_3 DE-16-250:per_3 2013:s_5 DE-16-250:s_5 2013:Senkov, Oleg DE-16-250:Senkov, Oleg 2013:Neurologische Universitätsklinik DE-16-250:Neurologische Universitätsklinik 2013:Verfasser DE-16-250:Verfasser 2013:pos_1 DE-16-250:pos_1
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container_title	International journal of biochemistry & cell biology
authorswithroles_txt_mv	Senkov, Oleg @@aut@@ Tikhobrazova, Olga @@aut@@ Dityatev, Alexander @@aut@@
publishDateDaySort_date	2012-01-01T00:00:00Z
hierarchy_top_id	320412261
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language_de	englisch
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topic	misc GluN2B misc Learning misc NCAM misc Polysialic acid misc PSA misc PSA-NCAM misc Synaptic plasticity 2013 hd2012 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_3 2013 s_5 2013 Senkov, Oleg 2013 Neurologische Universitätsklinik 2013 Verfasser 2013 pos_1
topic_unstemmed	misc GluN2B misc Learning misc NCAM misc Polysialic acid misc PSA misc PSA-NCAM misc Synaptic plasticity 2013 hd2012 2013 wissenschaftlicher Artikel (Zeitschrift) 2013 per_3 2013 s_5 2013 Senkov, Oleg 2013 Neurologische Universitätsklinik 2013 Verfasser 2013 pos_1
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title	PSA-NCAM synaptic functions mediated by its interactions with proteoglycans and glutamate receptors
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title_full	PSA-NCAM synaptic functions mediated by its interactions with proteoglycans and glutamate receptors Oleg Senkov, Olga Tikhobrazova, Alexander Dityatev
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title_sub	synaptic functions mediated by its interactions with proteoglycans and glutamate receptors
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title_sort	psa-ncamsynaptic functions mediated by its interactions with proteoglycans and glutamate receptors
title_auth	PSA-NCAM synaptic functions mediated by its interactions with proteoglycans and glutamate receptors
abstract	Dynamic regulation of glycosylation of the neural cell adhesion molecule (NCAM) by an unusual large negatively charged polysialic acid (PSA) is the major prerequisite for correct formation of brain circuitries during development and for normal synaptic plasticity, learning and memory in the adult. Traditionally, PSA is viewed as a de-adhesive highly hydrated molecule, which interferes with cell adhesion and promotes cellular/synaptic dynamics by steric hindrance. Analysis of synaptic functions of PSA-NCAM highlighted additional features of this molecule. First, PSA promotes interaction of NCAM with heparan sulfate proteoglycans and thus stimulates synaptogenesis. Second, PSA-NCAM modulates glutamate receptors: it restrains activity of extrasynaptic GluN2B-containing NMDA receptors and facilitates activity of a subset of AMPA receptors. Perturbation in polysialylation and/or NCAM expression in mouse models recapitulates many symptoms of human brain disorders such as schizophrenia, depression, anxiety and Alzheimer's disease. Available online 25 January 2012 Gesehen am 06.07.2018
abstractGer	Dynamic regulation of glycosylation of the neural cell adhesion molecule (NCAM) by an unusual large negatively charged polysialic acid (PSA) is the major prerequisite for correct formation of brain circuitries during development and for normal synaptic plasticity, learning and memory in the adult. Traditionally, PSA is viewed as a de-adhesive highly hydrated molecule, which interferes with cell adhesion and promotes cellular/synaptic dynamics by steric hindrance. Analysis of synaptic functions of PSA-NCAM highlighted additional features of this molecule. First, PSA promotes interaction of NCAM with heparan sulfate proteoglycans and thus stimulates synaptogenesis. Second, PSA-NCAM modulates glutamate receptors: it restrains activity of extrasynaptic GluN2B-containing NMDA receptors and facilitates activity of a subset of AMPA receptors. Perturbation in polysialylation and/or NCAM expression in mouse models recapitulates many symptoms of human brain disorders such as schizophrenia, depression, anxiety and Alzheimer's disease. Available online 25 January 2012 Gesehen am 06.07.2018
abstract_unstemmed	Dynamic regulation of glycosylation of the neural cell adhesion molecule (NCAM) by an unusual large negatively charged polysialic acid (PSA) is the major prerequisite for correct formation of brain circuitries during development and for normal synaptic plasticity, learning and memory in the adult. Traditionally, PSA is viewed as a de-adhesive highly hydrated molecule, which interferes with cell adhesion and promotes cellular/synaptic dynamics by steric hindrance. Analysis of synaptic functions of PSA-NCAM highlighted additional features of this molecule. First, PSA promotes interaction of NCAM with heparan sulfate proteoglycans and thus stimulates synaptogenesis. Second, PSA-NCAM modulates glutamate receptors: it restrains activity of extrasynaptic GluN2B-containing NMDA receptors and facilitates activity of a subset of AMPA receptors. Perturbation in polysialylation and/or NCAM expression in mouse models recapitulates many symptoms of human brain disorders such as schizophrenia, depression, anxiety and Alzheimer's disease. Available online 25 January 2012 Gesehen am 06.07.2018
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container_issue	4
title_short	PSA-NCAM
url	http://dx.doi.org/10.1016/j.biocel.2012.01.008 http://www.sciencedirect.com/science/article/pii/S135727251200012X
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author2	Tikhobrazova, Olga Dityatev, Alexander
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doi_str	10.1016/j.biocel.2012.01.008
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up_date	2024-07-05T01:51:49.355Z
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